A primer for quantum computing and its applications to healthcare and biomedical researchReview Published on 2024-08-272024-09-05 Journal: Journal of the American Medical Informatics Association [Category] update2024, [키워드] Biomedical research healthcare quantum quantum annealing Quantum computing universal gate-based quantum computing [DOI] 10.1093/jamia/ocae149 PMC 바로가기 [Article Type] Review
Gut Microbiota and Mitochondria: Health and Pathophysiological Aspects of Long COVIDReview Published on 2023-12-062024-09-05 Journal: International Journal of Molecular Sciences [Category] update2024, [키워드] ACE2 Dysbiosis dysfunction electron transport chain (ETC) hyperinflammation immunomodulation Infection Long COVID Microbiome PACS quantum SARS-CoV-2 [DOI] 10.3390/ijms242417198 PMC 바로가기 [Article Type] Review
Novel approach based on GQD-PHB as anchoring platform for the development of SARS-CoV-2 electrochemical immunosensorArticle Published on 2022-11-012022-11-15 Journal: Analytica chimica acta [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료제, [키워드] addition analyzed antibodies antibody approach Blood carbon Carbon nanomaterial Concentration conditions coronavirus spike protein decrease develop domain Dot DPV Electrochemical devices Fever functional Graphene human serum Immunosensors construction. Interaction investigated matrix effect Modification novel PBS performed platform probe Protein provided pulse quantum RBD SARS-CoV-2 selective SEM serum shown was tested was used [DOI] 10.1016/j.aca.2022.340442 PMC 바로가기
Virtual Screening and Quantum Chemistry Analysis for SARS-CoV-2 RNA-Dependent RNA Polymerase Using the ChEMBL Database: Reproduction of the Remdesivir-RTP and Favipiravir-RTP Binding Modes Obtained from Cryo-EM Experiments with High Binding AffinityArticle Published on 2022-09-202022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 신약개발, 치료법, 치료제, [키워드] acute respiratory syndrome adopted affinity Analysis anti-SARS-CoV-2 anti-viral activity approved binding affinity binding free energy ChEMBL Chemistry clinical development Compound coronavirus coronavirus disease COVID-19 Cryo-electron microscopy cryo-EM cryo-EM structure database docking drug drug candidates drug library drug repositioning drugs dsRNA fragment molecular orbital calculation Frequency frequency analysis interactions mode molecular Novel coronavirus ONIOM geometry optimization calculation pathogenic PDB performed predicted quantum quantum chemistry calculation RdRP reported reproduction RNA RNA-dependent RNA polymerase SARS-CoV-2 Screening screenings significantly suggested Treatment Virtual screening was performed [DOI] 10.3390/ijms231911009 PMC 바로가기
Development of a smartphone-based quantum dot lateral flow immunoassay strip for ultrasensitive detection of anti-SARS-CoV-2 IgG and neutralizing antibodiesAnti-SARS-CoV-2 IgG 및 중화항체의 초고감도 검출을 위한 스마트폰 기반 양자점 측방유동 면역분석 스트립 개발Article Published on 2022-08-012022-09-11 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] affected angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-SARS-CoV-2 IgG Antigen Blood donors common cold COVID-19 cross-reaction development diagnosed healthy blood donors human serum IgG immunoassay Inactivated vaccine Inactivated Vaccines individual Influenza influenza B inoculated lateral flow immunoassay Neutralizing antibodies neutralizing antibody nucleic acid nucleic acid test pandemic Patient patients with influenza platform populations positive proportion protective effect quantum Quantum dot reaction Receptor binding domain SARS-CoV-2 SARS-CoV-2 spike protein Smartphone Spike protein subunit vaccines the SARS-CoV-2 the vaccine the vaccines two patients Vaccine virus-neutralizing antibody was used Whole blood [DOI] 10.1016/j.ijid.2022.04.042 PMC 바로가기 [Article Type] Article
A Universal Fluorescent Immunochromatography Assay Based on Quantum Dot Nanoparticles for the Rapid Detection of Specific Antibodies against SARS-CoV-2 Nucleocapsid ProteinSARS-CoV-2 뉴클레오캡시드 단백질에 대한 특정 항체의 신속한 검출을 위한 양자점 나노입자 기반 범용 형광 면역크로마토그래피 분석Article Published on 2022-06-022022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody complex Concentration conditions conserved coronavirus coronavirus 2 coupling COVID-19 detection Diagnosis diagnostic Dot expansion expressed Fluorescence fluorescent fluorescent immunochromatography assay Host IgG immunochromatography life cycle limit of detection Mutation rates nanoparticle Ni-NTA nucleocapsid nucleocapsid protein optimization pathogenic point of care point-of-care Point-of-care detection probes Protein protein A purified purity quantum quantum dots Rapid related viruses respiratory respiratory infection SARS-CoV-2 SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody serological Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus shown Specific specific antibodies specific antibody specificity Spike protein Spike proteins susceptible Transmission Universal virus viruses was determined Zoonotic coronavirus zoonotic coronaviruses [DOI] 10.3390/ijms23116225 PMC 바로가기 [Article Type] Article
Applications of density functional theory in COVID-19 drug modelingCOVID-19 약물 모델링에 밀도 기능 이론 적용Review Published on 2022-05-012022-09-11 Journal: Drug discovery today [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral application applied approach coronavirus COVID-19 death density Density functional theory develop drug Drug discovery effective effort Factor followed by functional highlighting Interaction mechanisms molecular Molecular mechanics Molecular modeling pandemic QM/MM quantum Quantum mechanics Rational drug design recent Research SARS-CoV-2 severe acute respiratory syndrome Coronavirus targets [DOI] 10.1016/j.drudis.2021.12.017 PMC 바로가기 [Article Type] Review
The Role of Spike Protein Mutations in the Infectious Power of SARS-COV-2 Variants: A Molecular Interaction PerspectiveSARS-COV-2 변이체의 전염력에서 스파이크 단백질 돌연변이의 역할: 분자 상호작용 관점Article Published on 2022-04-052022-09-11 Journal: Chembiochem [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 receptor among others Analysis attachment B.1.1.28.1 B.1.351 bond Brazil correlated domain E484K mutation Effects Europe host cells hydrogen Hydrogen bond IMPROVE initial K417N molecular molecule molecules N501Y natural P.1 P.2 pair power quantum Quantum mechanics quantum theory RBD Receptor binding domain recognize reported residue residues role S477N Salt Bridge salt bridges SARS-CoV-2 virus significantly South Africa Specific spike Spike protein the spike protein theory United Kingdom variant virus wild type [DOI] 10.1002/cbic.202100393 PMC 바로가기 [Article Type] Article
Machine Learning with Quantum Seagull Optimization Model for COVID-19 Chest X-Ray Image ClassificationCOVID-19 흉부 X선 이미지 분류를 위한 양자 갈매기 최적화 모델을 사용한 기계 학습Article Published on 2022-03-302022-09-11 Journal: Journal of Healthcare Engineering [Category] 치료기술, 치료제, [키워드] addition approaches artificial artificial intelligence automated carried chest radiology chest X-ray classification COVID-19 COVID-19 diagnosis CXR dataset deep learning detect diagnosis of COVID-19 diagnostic disease effective extreme help Image intelligence machine learning management means Model mortality rate optimization outcomes performed quantum Respiratory system Spread target virus were assessed X-ray [DOI] 10.1155/2022/6074538 PMC 바로가기 [Article Type] Article
In vitro testing and computational analysis of specific phytochemicals with antiviral activities considering their possible applications against COVID-19Research article Published on 2022-02-012022-10-05 Journal: South African Journal of Botany [Category] 신약개발, 치료제, [키워드] Analysis Anti-inflammatory antioxidant Antioxidative antiviral activity Antiviral products antiviral property AutoDock Biflavonoid biflavonoids binding affinity biological activity calculate candidate Characteristics Chinese coefficient Compound compounds computational analysis COVID-19 docking docking score drug-likeness Effect electrostatic examined Features free radical identify in vitro Inflammation Interaction investigated LPS macrophages molecular MPro Partition proinflammatory mediator quantum SARS-CoV-2 scavenging selected stimulated suggested tested the SARS-CoV-2 virus thermodynamic was performed [DOI] 10.1016/j.sajb.2022.02.009 [Article Type] Research article