Identification of potential inhibitors of casein kinase 2 alpha of Plasmodium falciparum with potent in vitro activityArticle Published on 2023-11-152024-08-28 Journal: Med Instrum [Category] 말라리아, [키워드] Antimalarials docking malaria Quinazoline Virtual screening
Novel 2,4-disubstituted quinazoline analogs as antibacterial agents with improved cytotoxicity profile: Modification of the benzenoid partarticle Published on 2022-03-312024-09-01 Journal: Bioorganic & Medicinal Chemistry Letters [Category] 폐렴구균 감염증, [키워드] Antibacterial cytotoxicity Pyrazolo[3,4-d]pyrimidine Quinazoline Thieno[2,3-d]pyrimidine [Article Type] article
Novel 2,4-disubstituted quinazoline analogs as antibacterial agents with improved cytotoxicity profile: Optimization of the 2,4-substituentsArticle Published on 2021-12-312024-09-08 Journal: Bioorg Chem [Category] 폐렴구균 감염증, [키워드] Antibacterial antimycobacterial Bacterial resistance cytotoxicity Quinazoline PMC 바로가기
Property activity refinement of 2-anilino 4-amino substituted quinazolines as antimalarials with fast acting asexual parasite activityArticle Published on 2021-12-312024-09-10 Journal: Bioorg Chem [Category] 말라리아, [키워드] antimalarial malaria Plasmodium Quinazoline PMC 바로가기
Discovery of quinazoline derivatives as a novel class of potent and in vivo efficacious LSD1 inhibitors by drug repurposingResearch article Published on 2021-12-012022-10-05 Journal: European journal of medicinal chemistry [Category] 신약개발, [키워드] addition Antitumor Apoptosis Cancer therapy cancers candidate cells cellular demethylase derivative dosage Drug repurposing effort EGFR enzyme epigenetic modulator Erlotinib FDA-approved drug histone IC50 implicated induce inhibit inhibitor inhibitory activity LSD1 lung cancer Migration Pathogenesis provide Quinazoline reduction in screened significantly specificity suppress suppressed therapeutic target Treatment [DOI] 10.1016/j.ejmech.2021.113778 [Article Type] Research article
Design, synthesis and biological evaluation of quinazoline derivatives as anti-trypanosomatid and anti-plasmodial agentsarticle Published on 2015-12-312024-09-01 Journal: European Journal of Medicinal Chemistry [Category] 말라리아, [키워드] Dihydrofolate reductase Leishmania mexicana Plasmodium berghei Pteridin reductase Quinazoline Trypanosoma cruzi [Article Type] article