Discovery of new piperaquine hybrid analogs linked by triazolopyrimidine and pyrazolopyrimidine scaffolds with antiplasmodial and transmission blocking activitiesarticle Published on 2024-03-312024-09-01 Journal: European Journal of Medicinal Chemistry [Category] 말라리아, [키워드] P. falciparum PfDHODH Pyrazolopyrimidine quinoline Transmission blockers triazolopyrimidine [Article Type] article
Antimalarial Agents Derived from Metal-Amodiaquine Complexes with Activity in Multiple Stages of the Plasmodium Life CycleArticle Published on 2023-10-022024-08-27 Journal: Chemistry (Weinheim an Der Bergstrasse, Germany) [Category] 말라리아, [키워드] amodiaquine Infectious disease malaria organometallics quinoline
Development of 2-chloroquinoline based heterocyclic frameworks as dual inhibitors of SARS-CoV-2 M Pro and PL ProArticle Published on 2023-05-112024-09-05 Journal: International journal of biological macromolecules [Category] update2024, [키워드] Antiviral cysteine proteases dual inhibitor Imine MPro PLpro quinoline SARS-CoV-2 [DOI] 10.1016/j.ijbiomac.2023.124772 PMC 바로가기 [Article Type] Article
A foundational theoreticalAl12E12(E = N, P) adsorption and quinolone docking study: cage-quinolone pairs, optics and possible therapeutic and diagnostic applicationsArticle Published on 2023-05-012023-07-08 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), [키워드] Adsorption Aluminum cluster DFT Intermolecular forces Nanocages nitrogen phosphorus quinoline SARS–CoV–2 virus. [DOI] 10.1080/07391102.2022.2053742
Synthesis of Potential Antiviral Agents for SARS-CoV-2 Using Molecular Hybridization ApproachArticle Published on 2022-09-122022-11-15 Journal: Molecules [Category] SARS, 치료제, [키워드] agent antiviral property approach computational studies conjugate Conjugates cytotoxicity healthcare hybridization indole investigated molecular Molecular modeling Potential quinoline rhodanine. SAR-CoV-2 SARS-CoV-2 small molecule synthesis virus [DOI] 10.3390/molecules27185923 PMC 바로가기
Synthesis and in vitro Study of Artemisinin/Synthetic Peroxide-Based Hybrid Compounds against SARS-CoV-2 and CancerSARS-CoV-2 및 암에 대한 아르테미시닌/합성 과산화물 기반 하이브리드 화합물의 합성 및 시험관 내 연구Article Published on 2022-05-042022-09-11 Journal: ChemMedChem [Category] COVID19(2023년), SARS, 치료제, [키워드] active against acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed anti-cancer compounds anti-leukemia agents anti-SARS-CoV-2 anti-SARS-CoV-2 compounds antiviral agent Antiviral agents Artemisinin artemisinin based hybrids. artesunic acid Cancer Cell cell lines Compound coronavirus cytotoxic effect cytotoxic effects demonstrated disease Doxorubicin drug effective hybrid hybrid drug in vitro in vitro activity Infection inhibitory activity leukemia life-threatening Patients with cancer peroxide quinoline reported SARS-CoV-2 SARS-CoV-2 infections selectivity severe acute respiratory syndrome Coronavirus synthesis treat Vero E6 Vero E6 cell VERO E6 cells while [DOI] 10.1002/cmdc.202200005 PMC 바로가기 [Article Type] Article
A Review of Modifications of Quinoline Antimalarials: Mefloquine and (hydroxy)Chloroquine퀴놀린 항말라리아제의 수정에 대한 검토: 메플로퀸 및 (하이드록시)클로로퀸Review Published on 2022-02-022024-08-08 Journal: Molecules [Category] 말라리아, [키워드] Chloroquine derivatization Hydroxychloroquine late-stage modification mefloquine quinoline Semisynthesis [DOI] 10.3390/molecules27031003 PMC 바로가기 [Article Type] Review
Anti-SARS-CoV-2 Inhibitory Profile of New Quinoline Compounds in Cell Culture-Based Infection Models세포 배양 기반 감염 모델에서 새로운 퀴놀린 화합물의 항 SARS-CoV-2 억제 프로필Article Published on 2022-01-192022-09-11 Journal: Chemistry (Weinheim an Der Bergstrasse, Germany) [Category] SARS, 치료제, [키워드] antiviral drug antiviral drug assessment Cell Cell culture cell culture-based infection models Compound compounds COVID-19 human SARS-CoV-2 Infection inhibitory Model morpholine morpholine-quinoline hybrids New pandemic profile quinoline quinoline compounds. SARS-CoV-2 SARS-CoV-2 infections selected Surveillance synthesis Vaccine Virological [DOI] 10.1002/chem.202103861 PMC 바로가기 [Article Type] Article
Recent contributions of quinolines to antimalarial and anticancer drug discovery researcharticle Published on 2021-12-312024-09-01 Journal: European Journal of Medicinal Chemistry [Category] 말라리아, [키워드] Cancer malaria Medicinal chemistry quinoline [Article Type] article
Active components in Ephedra sinica stapf disrupt the interaction between ACE2 and SARS-CoV-2 RBD: Potent COVID-19 therapeutic agentsEphedra Sinica STAPF의 활성 성분은 ACE2와 SARS-COV-2 RBD 사이의 상호 작용을 방해합니다 : 강력한 COVID-19 치료제Article Published on 2021-10-052022-08-31 Journal: Journal of ethnopharmacology [Category] MERS, SARS, 치료제, [키워드] 293T-ACE2 4-hydroxy-6-methoxyquinoline-2-carboxylic acid (PubChem CID: 22017520) 4-hydroxyquinoline-2-carboxylic acid (PubChem CID: 3845) 4,6-dihydroxyquinoline-2-carboxylic acid (PubChem CID: 440752) ACE2 ACE2-RBD activity alleviate angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Asia Asthma binding domain Calu calu-3 cells carboxylic acid carried cells Chinese Cold component Compound compounds cough COVID-19 COVID-19 therapeutic agent Deterioration disrupt disrupting docking domain effort ephedra Ephedra sinica Ethanol HPLC hydrogen Hydrogen bond hydroxy indicated inhibit inhibit SARS-CoV-2 inhibiting Inhibition assays inhibitory activity Interaction Isolation knock-out Lung diseases material mechanism molecular docking NMR observé potent potential therapeutic agent potential therapeutic agents PPI PPI inhibitor Prevent protein-protein interaction provided pseudoviruses PubChem quinoline Quinoline-2-carboxylic acid S protein SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 S SARS-CoV-2 S protein SARS-CoV-2 virus SARS-CoV-2 virus infection Spike protein SPR Structure structures suggested surface plasmon surface plasmon resonance Symptom TCM the SARS-CoV-2 therapeutic agents these compound these compounds Traditional Chinese medicine treat viropexis virus infection were used [DOI] 10.1016/j.jep.2021.114303 PMC 바로가기 [Article Type] Article