A High-Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury뮤신-1 감소 화합물에 대한 고함량 선별 검사를 통해 포스타마티닙을 급성 폐 손상의 신속한 용도 변경 후보로 확인Article Published on 2020-10-292022-09-11 Journal: Cell Reports Medicine [Category] 비임상, 신약개발, [키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome ALI approved ARDS breath candidate Cell cell surface clinical development clinical outcomes Compound COVID-19 drug drug candidate Drug repurposing epithelial cells fostamatinib fostamatinib. identify Immune thrombocytopenia inhibitor lung lung epithelial cell Lung epithelial cells Lung injury metabolite mouse model MUC1 mucin pandemic pandemic spread Potential treatment potential treatments predict promote Protein R788 Rapid reduce repurposing respiratory distress Respiratory distress syndrome SARS-CoV-2 Screen spleen Spread Stage SYK syndrome the cell thrombocytopenia Treatment tyrosine [DOI] 10.1016/j.xcrm.2020.100137 PMC 바로가기 [Article Type] Article
A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic뮤신-1 감소 화합물에 대한 고함량 검사를 통해 포스타마티닙이 COVID-19 대유행 기간 동안 급성 폐 손상에 대한 신속한 용도 변경을 위한 후보로 확인됨Article Published on 2020-06-302022-09-11 Journal: bioRxiv [Category] 비임상, [키워드] acute lung injury apical surface approved ARDS arising biochemical marker breath candidate Cell cell surface clinical development clinical outcomes clinical trial clinical trials Compound content COVID-19 pandemic distress drug drug candidate Drug repurposing Efficacy elevated epithelial cells expressed fostamatinib identify Immune thrombocytopenia inhibitor Lung disease lung epithelial cell Lung epithelial cells Lung injury membrane-bound mouse model MUC1 mucin mucosal pandemic pandemic spread Patient patients with COVID-19 predict promoted Protein provide R788 Rapid rationale reduce reduced repurposing required respiratory distress Respiratory distress syndrome reveal SARS-CoV-2 SARS-COV-2 infection Screen spleen Spread Stage standing up SYK syndrome the cell thrombocytopenia Treatment tyrosine [DOI] 10.1101/2020.06.30.180380 PMC 바로가기 [Article Type] Article