Transcriptome analysis of PBMCs isolated from piglets treated with a miR-124 sponge construct identified miR124/IQGAP2/Rho GTPase as a target pathway support Salmonella Typhimurium infectionarticle Published on 2023-01-312024-09-01 Journal: Molecular Genetics and Genomics [Category] 살모넬라증, [키워드] Cdc42 IQGAP2 miR-124 Rac1 Salmonella [Article Type] article
In Vitro Antimalarial Activity of Inhibitors of the Human GTPase Rac1인비트로 인간 GTPase Rac1 억제제의 항말라리아 활성Article Published on 2021-11-012024-08-08 Journal: Med Instrum [Category] 말라리아, [키워드] antimalarial drug Plasmodium Rac1 [DOI] 10.1128/AAC.01498-21 PMC 바로가기
Apurinic/Apyrimidinic Endonuclease 1 Restricts the Internalization of Bacteria Into Human Intestinal Epithelial Cells Through the Inhibition of Rac1아푸리닉/아피리미딘 엔도뉴클레아제 1은 Rac1의 억제를 통해 인간 장 상피 세포로의 박테리아 내재화를 제한한다.Original Research Published on 2021-02-022024-07-29 Journal: Frontiers in immunology [Category] 살모넬라증, [키워드] AIEC LF82 strain apurinic/apyrimidinic endonuclease 1 internalization intestinal epithelial barrier Invasion Rac1 Salmonella Typhimurium [DOI] 10.3389/fimmu.2020.553994 PMC 바로가기 [Article Type] Original Research
RAC1 nitration at Y 32 IS involved in the endothelial barrier disruption associated with lipopolysaccharide-mediated acute lung injury지질다당류 매개 급성 폐 손상과 관련된 내피 장벽 파괴에 관여하는 Y 32 IS에서의 RAC1 니트로화Article Published on 2021-01-012022-09-11 Journal: Redox Biology [Category] SARS, 유전자 메커니즘, 진단, [키워드] Activation acute lung injury alveolar approach attenuate contractile COVID-19 dependent on determine effective therapy endothelial Endothelial cell endothelial cells functional high mortality human lung identify increase induce inhibitor involved junction lipopolysaccharide Local LPS lung Lung function Lung inflammation Lung injury mass spectrometry mechanism molecular murine model Nitration nucleotide peptide phenotype prevented pulmonary inflammation Rac1 Rac1. reduce reduced Rho GTPase Rho GTPases RHOA Sepsis severe pneumonia shielding shown switch systemic inflammation therapeutic target tyrosine vascular permeability [DOI] 10.1016/j.redox.2020.101794 PMC 바로가기 [Article Type] Article
The Virulence Polysaccharide of Salmonella Typhi Suppresses Activation of Rho Family GTPases to Limit Inflammatory Responses From Epithelial Cells살모넬라 장티푸스의 독성 다당류는 상피 세포의 염증 반응을 제한하기 위해 Rho 가족 GTPase의 활성화를 억제한다.Original Research Published on 2019-05-082024-07-29 Journal: Frontiers in Cellular and Infection Microbiology [Category] 살모넬라증, [키워드] Cdc42 Prohibitin Rac1 Salmonella Typhi Vi polysaccharide [DOI] 10.3389/fcimb.2019.00141 PMC 바로가기 [Article Type] Original Research
Molecular Mechanisms of Hypoxic Responses via Unique Roles of Ras1, Cdc24 and Ptp3 in a Human Fungal Pathogen Cryptococcus neoformans인간 곰팡이 병원체 Cryptococcus neoformans에서 Ras1, Cdc24 및 Ptp3의 고유한 역할을 통한 저산소 반응의 분자 메커니즘Research Article Published on 2014-04-242022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Actin affected Analysis biological processe biological processes C. neoforman C. neoformans CAMP caused Cdc42 central gene chromosome Compound Concentration condition conserved Critical Cryptococcus Cryptococcus neoforman Cryptococcus neoformans cytoskeletal Deletion downstream eight ergosterol eukaryotic cells expression of gene family function fungal genes encoding genetic analysis genotoxic growth growth defect growth retardation GTPase guanine Human human host hypoxia hypoxic hypoxic condition hypoxic conditions indicated inhibit inhibitor involved maintenance molecular mutant not affected nucleotide osmotic oxygen pathogen pathway Pathways phosphatase phosphatases Phosphorylation Protein protein translation Rac1 Rac2 regulate required rescued response Rho GTPase RNA RNA sequencing role sequence similarity single cells strain Strains suggested suppressor These cells Tolerance unique wild-type strain [DOI] 10.1371/journal.pgen.1004292 PMC 바로가기 [Article Type] Research Article
Arf6 coordinates actin assembly through the WAVE complex, a mechanism usurped by Salmonella to invade host cellsArf6는 WAVE 복합체를 통해 액틴 조립을 조정하며, 살모넬라가 숙주 세포를 침입하는 데 사용하는 메커니즘입니다.journal-article Published on 2013-10-152024-07-31 Journal: Microbial Cell Factories [Category] 살모넬라증, [키워드] Infection lamellipodia nucleation-promoting factor. Rac1 [DOI] 10.1073/pnas.1311680110 [Article Type] journal-article