Chinese herbal formula ruangan granule enhances the efficacy of entecavir to reverse advanced liver fibrosis/early cirrhosis in patients with chronic HBV infection: A multicenter, randomized clinical trialRandomized Controlled Trial Published on 2023-04-012023-06-12 Journal: Pharmacological research [Category] B형 간염, [키워드] Chronic Hepatitis B entecavir Liver fibrosis randomized clinical trial Ruangan granule. [DOI] 10.1016/j.phrs.2023.106737 PMC 바로가기 [Article Type] Randomized Controlled Trial
The efficacy of Zafirlukast as a SARS-CoV-2 helicase inhibitor in adult patients with moderate COVID-19 Pneumonia (pilot randomized clinical trial)Randomized Controlled Trial Published on 2022-12-012023-07-10 Journal: Journal of infection and public health [Category] COVID19(2023년), [키워드] coronavirus COVID-19 randomized clinical trial SARS-CoV-2 Zafirlukast. [DOI] 10.1016/j.jiph.2022.11.016 PMC 바로가기 [Article Type] Randomized Controlled Trial
Re: Early administration of tocilizumab in hospitalized COVID-19 patients with elevated inflammatory markers; COVIDSTORMArticle Published on 2022-11-012022-11-15 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), SARS, 진단, [키워드] Abstract administration Anti-interleukin-6 receptor COVID-19 elevated hospitalized COVID-19 patient Inflammatory randomized clinical trial Sub-groupe analyses Tocilizumab tocilizumab. [DOI] 10.1016/j.cmi.2022.06.013 PMC 바로가기
The effect of Nutrition Bio-shield superfood (NBS) on disease severity and laboratory biomarkers in patients with COVID-19: A randomized clinical trialArticle Published on 2022-11-012022-11-15 Journal: Microbial pathogenesis [Category] SARS, 바이오마커, [키워드] ALP assigned baseline body temperature can be used clinical clinical trial Clinical trial study control group COVID-19 COVID-19 disease COVID-19 disease severity CPK CRP determine dimer disease severity Effect effective ELISA kit ESR IL-6 immune system IMPROVE Intervention intervention group Iran laboratory biomarker laboratory biomarkers laboratory parameter LDH lymphocyte Lymphocyte count nutrition Nutrition bio-shield superfood. oxygen saturation Patient patients with COVID-19 performed Placebo Randomized randomized clinical trial receiving Result Serum level serum sample SGOT SGPT significant decrease significant increase single-blind Superfood Tehran tested the mean TNF-α Treatment Trial two group Two-arm variable was performed WBC [DOI] 10.1016/j.micpath.2022.105792 PMC 바로가기
Coronavirus disease 2019 subphenotypes and differential treatment response to convalescent plasma in critically ill adults: secondary analyses of a randomized clinical trialArticle Published on 2022-11-012022-11-15 Journal: Intensive care medicine [Category] Fulltext, MERS, 바이오마커, [키워드] ABO-compatible convalescent plasma Adaptive platform trial Adults analysis assigned Biomarker Biomarkers chemokines community-acquired pneumonia convalescent plasma Convalescent plasma therapy coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critically ill critically ill patients Cytokines difference effector immune responses elevated endothelial explain heterogeneous homogeneous Hypothesis immunologically immunotherapies Inflammation IQR median multifactorial organ support outcome outcomes patients Population precision medicine Prevalence Randomized randomized clinical trial RCT RCTs REMAP-CAP reported secondary analysis Subphenotypes. tested therapy treatment effect Treatment response usual care with COVID-19 [DOI] 10.1007/s00134-022-06869-w PMC 바로가기
Efficacy and safety of nitazoxanide in treating SARS-CoV-2 infection: a systematic review and meta-analysis of blinded, placebo-controlled, randomized clinical trialsArticle Published on 2022-11-012022-11-15 Journal: European Journal of Clinical Pharmacology [Category] SARS, 치료제, [키워드] 95% CI 95% confidence interval addition anti-inflammatory effect antiparasitic antiviral activity blinded clinical benefit continuous variable COVID-19 D-dimer D-dimer level death dichotomous variable Disease progression Effect effect size Efficacy and safety element eligibility enrolled Evidence Frequency ICU admission in vitro individual Inflammation Invasive mechanical ventilation lactate dehydrogenase LDH magnitude Meta-analysis Mild moderate Moderate COVID-19 nitazoxanide no difference Patient patients peer-reviewed performed Placebo placebo-controlled positive positive RT-PCR Primary outcome randomized clinical trial RCT RCTs receiving reducing reduction in reported risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection. secondary outcome serum biomarker SMD standardized mean difference systematic review tested to define treat treated Viral load WBC were used White blood cell with COVID-19 [DOI] 10.1007/s00228-022-03380-5 PMC 바로가기
Effect of a diet based on Iranian traditional medicine on inflammatory markers and clinical outcomes in COVID-19 patients: A double-blind, randomized, controlled trialResearch article Published on 2022-10-012022-10-05 Journal: European Journal of Integrative Medicine [Category] 바이오마커, 임상, [키워드] traditional persian medicine acute respiratory syndrome Antiviral treatment appear approved baseline characteristics C-reactive protein cause caused Cicer Cicer arietinum Clinical outcome clinical trial Combination conducted control group cough COVID-19 COVID-19 patient COVID-19 patients demographics develop diagnosis of COVID-19 diet double-blind education Effect effective Efficacy and safety Ficus ficus carica headache help Hospitalization Inflammatory biomarker Inflammatory marker Intervention intervention group Iran Laboratory life-threatening Medicine Ministry of Health myalgia no significant difference Organ failure Patient randomized clinical trial randomized, controlled trial regimen Research Result Reza Safflower Sample size SARS-CoV-2 significant difference significantly lower SPSS software statistical analysis supportive care Symptom Symptoms Tehran Traditional Treatment treatment period Treatment protocol variables virus Vitis Vitis vinifera weakness while [DOI] 10.1016/j.eujim.2022.102179 [Article Type] Research article
COVIDMED – An early pandemic randomized clinical trial of losartan treatment for hospitalized COVID-19 patientsShort communication Published on 2022-10-012022-10-30 Journal: Contemporary Clinical Trials Communications [Category] COVID-19, 임상, 치료법, [키워드] AE/SAE Analysis Angiotensin converting enzyme inhibitor (ACEi) Angiotensin II receptor Blocker (ARB) Arm baseline controls COVID-19 COVID-19 patients double-blinded Efficacy and safety Enrollment Final hospitalized COVID-19 patient hospitalized COVID-19 patients Hydroxychloroquine IMPROVE Lopinavir-ritonavir losartan Mortality MOST objective outcome pandemic parameter Patient Placebo placebo-controlled platform primary endpoint Randomized randomized clinical trial Randomized clinical trial (RCT) RCT Result SARS-CoV-2 score slow standard care the mean Treatment [DOI] 10.1016/j.conctc.2022.100968 [Article Type] Short communication
COVID-19 Convalescent Plasma and Clinical Trials: Understanding Conflicting OutcomesArticle Published on 2022-09-212022-11-16 Journal: Clinical microbiology reviews [Category] Fulltext, MERS, 변종, [키워드] acute respiratory syndrome administration analyzed antibody approaches benefit case sery CCP clinical Clinical improvement clinical settings clinician Confusion convalescent convalescent plasma coronavirus COVID-19 COVID-19 pandemic criteria defined demonstrated Diagnosis disease severity dose Efficacy Emergency use authorization Epidemics EUA FDA Hospitalization include less mechanism Molecular diagnosis Mortality Neutralizing Neutralizing antibodies Neutralizing titer omicron onset of symptoms outcome Patient plasma Pneumonia polyclonal propensity score-matched randomization Randomized randomized clinical trial Randomized controlled trial RCT RCTs reductions in reported resulting SARS-CoV-2 serostatus Survivors Therapies Treatment Trial understanding variable variant Ventilation Viral neutralization tests viral neutralization tests. WHO guideline [DOI] 10.1128/cmr.00200-21 PMC 바로가기
The Effect of Short Treatment with Nigella Sativa on Symptoms, the Cluster of Differentiation (CD) Profile, and Inflammatory Markers in Mild COVID-19 Patients: A Randomized, Double-Blind Controlled TrialArticle Published on 2022-09-192022-11-16 Journal: International Journal of Environmental Research an [Category] SARS, 치료기술, [키워드] age Analysis Anti-inflammatory Asymptomatic Cluster control group Controlled Course COVID-19 COVID-19 cases demonstrated different dose differentiation disease dose double-blind Effect Final FIVE Gender group groups Inflammatory Inflammatory marker Intervention investigated marker Mild mild COVID-19 Nigella Nigella Sativa parameter Patient patients with COVID-19 placebo-controlled clinical trial procalcitonin profile randomized clinical trial randomized clinical trial. Randomly SARS-COV-2 infection Saudi Arabia Seven significant difference significant effect subject Symptoms Treatment WBC were assessed while [DOI] 10.3390/ijerph191811798 PMC 바로가기