Humoral Immune Response to SARS-CoV-2 Spike Protein Receptor-Binding Motif Linear EpitopesArticle Published on 2024-03-222024-09-05 Journal: Vaccines [Category] update2024, [키워드] Ig subclasses IgA IgG Neutralizing antibodies Receptor-binding domain receptor-binding motif SARS-CoV-2 spike glycoprotein variants [DOI] 10.3390/vaccines12040342 PMC 바로가기 [Article Type] Article
Selective adaptation of SARS-CoV-2 Omicron under booster vaccine pressure: a multicentre observational studyArticle Published on 2023-10-202024-09-05 Journal: eBioMedicine [Category] update2024, [키워드] booster vaccinations breakthrough clinical variables convergent evolution Imprinted immunity omicron Re-infections receptor-binding motif SARS-CoV-2 Selective adaptation spike RBD Vaccine pressure variant of concern (VOC) [DOI] 10.1016/j.ebiom.2023.104843 PMC 바로가기 [Article Type] Article
The spike receptor-binding motif G496S substitution determines the replication fitness of SARS-CoV-2 Omicron sublineageArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] approach Cell culture circulating comparable contribute COVID-19 determine experimental animal models fitness. G496S genetics monoclonal antibodies omicron Omicron BA.1 Omicron BA.2 pathogenicity phenotype predominant receptor-binding motif Replication SARS-CoV-2 SARS-CoV-2 variant sensitivity spike mutation therapeutic trajectory [DOI] 10.1080/22221751.2022.2111977 PMC 바로가기
An antibody from single human VH-rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusionArticle Published on 2022-10-282022-11-15 Journal: Science Immunology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] antibodies antibody approved B cell BCR binding epitope blocked CDR3 contribute described elicited Health humanized immunogen inhibiting Last Lattice mechanism of action membrane fusion mice Modification mouse model neutralization activity neutralize neutralized Neutralizing antibodies neutralizing antibody omicron Pathogens RBD receptor receptor-binding motif Recombination SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 variant sequence Spike protein therapeutic therapeutic potential Vaccine Wuhan-Hu-1 [DOI] 10.1126/sciimmunol.add5446 PMC 바로가기
Contrasting Patterns in the Early Stage of SARS-CoV-2 Evolution between Humans and MinksArticle Published on 2022-09-012022-11-16 Journal: Molecular Biology and Evolution [Category] SARS, 변종, [키워드] adaptive amino acid changes analyzed change circulating deviate domain early phase Epidemic Epidemics Evolution feature Frequency Genetic genetic hitchhiking Host Human humans Infection Ka/Ks lack late phase mink Mutation mutations Neutral nonsynonymous other coronaviruses outbreak pandemic parental pattern positive Positive selection produced receptor-binding motif SARS-CoV SARS-CoV-2 selection process sequence site frequency spectrum site frequency spectrum. Stage Strong synonymous the SARS-CoV-2 the spike protein unique variant virus [DOI] 10.1093/molbev/msac156 PMC 바로가기
Targeting the Receptor-Binding Motif of SARS-CoV-2 with D-Peptides Mimicking the ACE2 Binding Helix: Lessons for Inhibiting Omicron and Future Variants of ConcernACE2 결합 나선을 모방한 D-펩타이드로 SARS-CoV-2의 수용체 결합 모티프 표적화: 오미크론 및 우려되는 미래 변이를 억제하기 위한 교훈Article Published on 2022-08-082022-09-11 Journal: Journal of Chemical Information and Modeling [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 binding Alpha approach B.1.1.529 Beta binding blocked concern COVID-19 pandemic demonstrated domain Future high-affinity binding IC50 IC50s in vitro In vitro infection Infection inhibiting inhibitor lesson motif Mutation neutralizing monoclonal antibodies omicron Omicron variant overlapping predicted public interest RBD receptor-binding motif SARS-CoV-2 Spike protein Spread targeting the RBD the spike protein variant VoC VOCs [DOI] 10.1021/acs.jcim.2c00500 PMC 바로가기 [Article Type] Article
Structure-selected RBM immunogens prime polyclonal memory responses that neutralize SARS-CoV-2 variants of concern구조 선택 RBM 면역원은 우려되는 SARS-CoV-2 변이체를 중화하는 다클론성 기억 반응을 일으킵니다.Article Published on 2022-07-212022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 Affect Amino acid amino acid residue antibody Antibody Response B.1.351 B.1.617.2 booster C57BL/6 can be used conserved COVID-19 pandemic domain effort full-length full-length spike protein immunization immunogen immunogenic immunogens Immunoglobulin majority memory response mice neutralize Neutralizing Neutralizing antibodies neutralizing antibody Plasmid polyclonal Prevent Protein Proteins purified RBD RBM receptor-binding motif Recombinant spike protein resulting SARS-CoV-2 variant sera spike Spike protein Spike proteins the antibody response Transmission Vaccine variants variants of concern virus VoC VOCs vulnerability WA1 wildtype [DOI] 10.1371/journal.ppat.1010686 PMC 바로가기 [Article Type] Article
Receptor-Binding-Motif-Targeted Sanger Sequencing: a Quick and Cost-Effective Strategy for Molecular Surveillance of SARS-CoV-2 Variants수용체 결합 모티브 표적 생어 시퀀싱: SARS-CoV-2 변이체의 분자 감시를 위한 빠르고 비용 효율적인 전략Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] Coronavirus, COVID19(2023년), SARS, 변종, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adopted aligned Alpha Alpha variant B.1.1.529 B.1.1.7 B.1.617.2 causative agent changes in CLC Clinical use coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic Critical death Delta delta variant develop disease spread Genome gold gold standard Infection involved Lineage lineages modifications molecular mutate Mutation mutations nasal nasal swab nasal swabs nucleocapsid omicron Omicron variant Omicron variants pandemic prevalent Prevent public health receptor-binding motif Receptor-binding motif (RBM) resource Saliva Sanger sequencing SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sequence sequences Sequencing severe acute respiratory syndrome Coronavirus Spike protein Spread Strategy Surveillance swab samples the disease variant variant surveillance. variants WGS whole-genome sequencing [DOI] 10.1128/spectrum.00665-22 PMC 바로가기 [Article Type] Article
Healthy humans can be a source of antibodies countering COVID-19건강한 사람은 COVID-19에 대항하는 항체의 원천이 될 수 있습니다Article Published on 2022-05-012022-09-11 Journal: Bioengineered [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] ACE2 ACE2 competitor Analysis angiotensin angiotensin-converting enzyme 2 antibody antibody cocktail approach authentic SARS-CoV-2 virus best binding binding affinity Blood bypassing can be used characterized Combination COVID-19 COVID-19 diagnostics COVID-19 therapeutics detect detecting antibody diagnostic eight ELISA epitope Epitopes Evidence Evolution flow cytometry fluorescence microscopy healthy donor healthy donors Human humanized IgG immune in vitro infected patients Infection inhibit SARS-CoV-2 Isolation mice monoclonal antibodies naïve neutralization titers neutralize neutralizing antibody RBM receptor Receptor binding domain receptor-binding motif recognize SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 virus single B cell single-chain antibody specificity Spike protein SPR tested therapeutic unique virus infection yeast [DOI] 10.1080/21655979.2022.2076390 PMC 바로가기 [Article Type] Article
Seroreactivity of the Severe Acute Respiratory Syndrome Coronavirus 2 Recombinant S Protein, Receptor-Binding Domain, and Its Receptor-Binding Motif in COVID-19 Patients and Their Cross-Reactivity With Pre-COVID-19 Samples From Malaria-Endemic AreasCOVID-19 환자에서 중증 급성 호흡기 증후군 코로나바이러스 2 재조합 S 단백질, 수용체 결합 도메인 및 이의 수용체 결합 모티브의 혈청반응성과 말라리아 발병 지역의 코로나19 이전 샘플과의 교차 반응성Article Published on 2022-04-272022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 말라리아, 진단, 치료기술, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition age anti-S antibody antibody Antibody Response Antibody responses Antigen antigens Area Asthma blood sample Blood samples Community Comorbidities conducted coronavirus coronavirus 2 COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 samples cross-reactive antibody cross-reactivity determine diabete diabetes disease Donor ELISA full-length Gender hospital IgG antibodies IgG antibody individual malaria malaria endemic-area participant Patient Plasmodium falciparum Plasmodium falciparum infection Pre-COVID-19 samples Protein RBD RBM Receptor-binding domain receptor-binding motif Recognition Recombinant S regions respiratory response responses S protein Sample SARS-CoV-2 SARS-CoV-2 proteins SARS-CoV-2 S SARS-CoV-2 S protein sera seroreactivity severe acute respiratory syndrome Coronavirus Study participants tested the receptor-binding domain the SARS-CoV-2 Treatment triggered weakened West while [DOI] 10.3389/fimmu.2022.856033 PMC 바로가기 [Article Type] Article