Antigenic mapping reveals sites of vulnerability on α-HCoV spike proteinArticle Published on 2022-11-042022-11-15 Journal: Communications Biology [Category] SARS, 진단, [키워드] antigenic appear characterized conserved distal domain dominant effective epitope Epitopes feasibility HCoV-229E HCoV-NL63 highlight human coronavirus imperative N-terminal domain Neutralizing neutralizing antibody panel of antibody Protein RBD Receptor binding domain receptor binding site recognize representing reveal S protein S proteins similarity spike Spike protein subset the SARS-CoV-2 understanding Vaccine design Vaccine development [DOI] 10.1038/s42003-022-04160-8 PMC 바로가기
Reduced B cell antigenicity of Omicron lowers host serologic responseArticle Published on 2022-10-182022-11-15 Journal: Cell Reports [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Antibody Response Antibody titer antigenicity B cell Breakthrough infection common cold coronavirus computational structural biology conserved CP: Immunology CP: Microbiology cross-reactivity deep learning ELISA Epitopes evade explain feature geometric Host Infection less Lower mechanism Mice immunization experiment mutated Neutralizing omicron Omicron variant of concern RBD RBS Receptor binding Receptor binding domain receptor binding site reduced reduction reduction in reveal SARS-CoV-2 Serologic response serological response serum Spike protein trajectory vaccine-induced antibody variant variants viral evolution [DOI] 10.1016/j.celrep.2022.111512 PMC 바로가기
Identification of a cross-neutralizing antibody that targets the receptor binding site of H1N1 and H5N1 influenza virusesArticle Published on 2022-09-022022-10-06 Journal: Nature Communications [Category] Fulltext, 신종인플루엔자, 진단, [키워드] analyses antibody antiviral drug benefit chimeric conserved cross-neutralization cross-neutralizing cross-protection eight engage epitope overlapping Evidence H1N1 H5N1 identification in vivo Influenza influenza vaccines Influenza virus mAb molecular monoclonal antibody neutralization Neutralizing activity offer pandemic receptor binding site residue Surface glycoprotein target Tolerance Vaccine viral challenge virus virus entry viruses [DOI] 10.1038/s41467-022-32926-5 PMC 바로가기 [Article Type] Article
A broad and potent neutralization epitope in SARS-related coronavirusesSARS 관련 코로나바이러스의 광범위하고 강력한 중화 에피토프Article Published on 2022-07-192022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibodies antibody B.1.1.529 benefit conserved conserved epitope coronavirus CR3022 cross-neutralizing cross-neutralizing antibody Effectiveness elicited epitope high potency Interaction NAbs natural infection neutralization neutralize Neutralizing antibodies neutralizing antibody omicron RBS receptor binding site reduced respiratory SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-related coronavirus SARS-related coronaviruses therapeutic therapeutic antibodies vaccination Vaccine variants variants of concern VOCs X-ray X-ray crystallography [DOI] 10.1073/pnas.2205784119 PMC 바로가기 [Article Type] Article
OMICRON: Virology, immunopathogenesis, and laboratory diagnosisOMICRON: 바이러스학, 면역병리학 및 실험실 진단Review Published on 2022-07-012022-09-11 Journal: The journal of gene medicine [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addressed Alpha antibody approach B.1.1.529 Beta Biology Booster vaccine Clinical sign coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 decrease Delta Diagnosis diagnostic dose Gamma Genetic Genome Health Organization Immunopathogenesis immunopathological increased risk Infection Laboratory management Mortality Mutation omicron Omicron variant pediatrics Re-infection receptor binding site respiratory virus risk severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) severity Signs and symptoms Spike protein Spread Symptoms therapeutic Transmissibility understanding Vaccine vaccine response Vaccines variant variants variants of concern Virology World Health Organization [DOI] 10.1002/jgm.3435 PMC 바로가기 [Article Type] Review
Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice다가 설계된 단백질은 우려되는 SARS-CoV-2 변이체를 중화하고 마우스의 감염에 대한 보호를 제공합니다Article Published on 2022-05-252022-09-11 Journal: Science Translational Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody antigenic antigenic drift Antiviral apex autoimmune responses B.1.1.529 B.1.617.2 clinically coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cryo-electron microscopy Delta Efficacy expression form greater Infection inhibitors of SARS-CoV-2 intranasally mice miniprotein monoclonal antibodies monoclonal antibody multivalent neutralize neutralized New omicron other variant pandemic pathogen Prophylactic Protein receptor Receptor binding domain receptor binding domains receptor binding site respiratory SARS-CoV-2 SARS-CoV-2 variant severe acute respiratory syndrome Coronavirus Spike protein tested the spike protein therapeutic therapeutic strategy Treatment treatment of COVID-19 trimeric spike TRIPOD variant Viral viral escape [DOI] 10.1126/scitranslmed.abn1252 PMC 바로가기 [Article Type] Article
Inhibition of avian influenza virus H9N2 infection by antiviral hexapeptides that target viral attachment to epithelial cellsArticle Published on 2022-05-012023-06-22 Journal: Virus research [Category] 조류인플루엔자, [키워드] H9N2 virus hemagglutinin peptides phage display receptor binding site [DOI] 10.1016/j.virusres.2022.198745
An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concernResearch Articles Published on 2022-04-262022-10-04 Journal: Science Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 ACE2-binding site animal models antibody antigenic diversity antigenic site Beta concern conserved COVID-19 Cryo-electron microscopy Delta description domain effective epitope Evolution of SARS-CoV-2 experiments Gamma hamster Human monoclonal antibody hydrophobic residue Immune escape in vitro mice monoclonal antibody Mutation neutralization neutralization capacity Neutralizing activity omicron pandemic Prophylactic prophylactically Protective receptor binding site retained SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants site-directed mutagenesis target the S protein the spike protein therapeutic therapeutic activity VOCs [DOI] 10.1126/sciimmunol.abp9312 PMC 바로가기 [Article Type] Research Articles
Correlation between Commercial Anti-RBD IgG Titer and Neutralization Titer against SARS-CoV-2 Beta VariantArticle Published on 2021-11-272022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] Abbott SARS-CoV-2 IgG Affect anti-N IgG anti-RBD Anti-RBD IgG antibody antibody assay Antibody binding Antibody test Antibody titer B.1.351 Beta Beta variant binding antibody Concentration correlation COVID-19 COVID-19 case COVID-19 patients current determine Effectiveness geometric GMT IgG Lineage Live virus microneutralization Mutation neutralization neutralizing antibody Neutralizing antibody titer nucleocapsid predict Protein RBD Receptor binding domain receptor binding site required SARS-CoV-2 SARS-CoV-2 variant significantly lower Spearman spike protein RBD the SARS-CoV-2 titer Vaccine variant variants virus VoC VOCs was determined were measured wild type [DOI] 10.3390/diagnostics11122216 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Spike Protein Stabilized in the Closed State Induces Potent Neutralizing ResponsesVaccines and Antiviral Agents Published on 2021-05-072022-10-30 Journal: Journal of Virology [Category] COVID-19, SARS, [키워드] ACE2 antibody B.1.351 binding conformational conformations described epitope expected Glycoproteins immune response Immunity immunization immunized include individuals induce inhibit Interaction long-lasting majority mRNA vaccine Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody response neutralizing response observation P.1 potent prefusion Prevent Protein raised RBD receptor Receptor binding domain receptor binding site recruit response robust S protein SARS-CoV-2 SARS-CoV-2 strains SARS-CoV-2 vaccine SARS-CoV-2 variants sequence sera spike Spike protein spikes stability state T cell response the antibody response the RBD the spike protein trimer trimeric S protein Vaccination strategy Vaccine Vaccines variants variants of concern viral spike protein virion [DOI] 10.1128/JVI.00203-21 PMC 바로가기 [Article Type] Vaccines and Antiviral Agents