Cardiovascular Effects of Environmental Metal Antimony: Redox Dyshomeostasis as the Key Pathogenic Driverarticle Published on 2023-04-012024-09-05 Journal: Antioxidants & redox signaling [Category] update2024, [키워드] antimony toxicity cardiovascular diseases metal cardiotoxicity Redox imbalance [DOI] 10.1089/ars.2022.0185 PMC 바로가기 [Article Type] article
Redox imbalance in COVID-19 pathophysiologyArticle Published on 2022-10-012022-11-16 Journal: Redox Biology [Category] 치료기술, [키워드] alteration Analysis antioxidant Ascorbate association biochemical assay Blood circulating Clinical outcome contributing to control subject COVID COVID-19 COVID-19 infection Diagnosis electron Electron paramagnetic resonance enrichment analysis enrolled EPR evaluate greater ICAM-1 ICU indicated Inflammation Inflammatory intensive care marker Mortality mRNA Multiplex assay multivariate non-ICU non-specific Oxidant oxidative stress parameter pathophysiologic pathophysiology pathway performed Peripheral blood positive predict predicted quantified redox Redox imbalance reducing reduction in repetition required SARS-CoV-2 Sequencing serum Serum level significant increase subject subjects therapeutic strategy Topic transcriptomics TSLP uric acid Vascular VCAM-1 Virus Disease was performed [DOI] 10.1016/j.redox.2022.102465 PMC 바로가기
The Role of Vitamin D in Supporting Health in the COVID-19 EraReview Published on 2022-03-252023-07-02 Journal: International Journal of Molecular Sciences [Category] SARS, [키워드] COVID-19 immunomodulation Inflammation mitochondrial uncoupling oxidative stress Redox imbalance Vitamin D vitamin D deficiency Vitamin D supplementation [DOI] 10.3390/ijms23073621 PMC 바로가기 [Article Type] Review
Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicityArticle Published on 2022-02-082022-10-04 Journal: Nature Communications [Category] 유전자 메커니즘, [키워드] alcohol antioxidant Apoptosis bone marrow failure Caenorhabditis elegan Cancer metabolism cause cellular cellular damage Chemical genetics coding contributing to crosslinking cytotoxicity DNA DNA damage DNA repair endogenous enzyme formaldehyde functional GSH human cell Mechanisms of disease metabolic pathways metabolite Mutation oxidative stress Patient prevented PROTECT question raising Redox imbalance reduced resulting syndrome Therapeutic benefit thiol group thought Toxicity Trigger underlie yielding [DOI] 10.1038/s41467-022-28242-7 PMC 바로가기 [Article Type] Article
Redox Homeostasis and Immune Alterations in Coronavirus Disease-19Review Published on 2022-01-192022-10-28 Journal: Biology [Category] COVID-19, [키워드] Affect alteration antioxidant caused characterized Clinical features Compound coronavirus 2 COVID COVID-19 COVID-19 severity Cytokine storm disease Disease progression disturbance Effectiveness Evidence extreme feature host cell immune regulation immune response include Intervention involved knowledge Lung injury Lungs management mechanism moderate organ damage Other pandemic predisposition Prevent pro-inflammatory response reactive redox redox balance Redox imbalance Regulation respiratory respiratory tract SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection severe disease Severe infection Signaling simple susceptibility Symptom therapeutic targets Treatment Variability variety [DOI] 10.3390/biology11020159 PMC 바로가기 [Article Type] Review
Neurological Implications of COVID-19: Role of Redox Imbalance and Mitochondrial DysfunctionReview Published on 2021-06-102023-06-16 Journal: Molecular neurobiology [Category] MERS, SARS, [키워드] Bioenergetic sensors COVID-19 Mitochondria neurological manifestations Redox imbalance [DOI] 10.1007/s12035-021-02412-y PMC 바로가기 [Article Type] Review
Double-blind, Randomized, Placebo-controlled Trial With N-acetylcysteine for Treatment of Severe Acute Respiratory Syndrome Caused by Coronavirus Disease 2019 (COVID-19)Randomized Controlled Trial Published on 2021-06-012022-10-04 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 임상, [키워드] acute respiratory syndrome administration Admission age alveolar epithelium angiotensin angiotensin-converting enzyme 2 Apoptosis Brazil cells Characteristics Chest computed tomography clinical Comorbidities conducted coronavirus coronavirus disease COVID-19 Department determine disease severity double-blind Emergency Endotracheal intubation Endpoint enrolled Evolution Gas exchange group groups High dose homeostasis ICU inactivation increase in induce Inflammation intensive care Laboratory test Local mechanical ventilation Medicine Mortality NAC no significant difference not affect oxyhemoglobin saturation Patient patients with COVID-19 placebo-controlled Pneumonia primary endpoint Randomized receive Redox imbalance registry respiratory Respiratory failure respiratory rate SARS-CoV-2 secondary Secondary endpoints severe COVID-19 Sex single-center suppress the placebo group Trial [DOI] 10.1093/cid/ciaa1443 PMC 바로가기 [Article Type] Randomized Controlled Trial
What Can Cellular Redox, Iron, and Reactive Oxygen Species Suggest About the Mechanisms and Potential Therapy of COVID-19?Cellular and Infection Microbiology Published on 2020-12-142022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress Alter ARDS Ascorbate Can cause cellular chelators coronavirus disease COVID-19 Critical Diseases disrupt Effects Evidence Ferroptosis generate glutathione help Infection iron oxidative damage Perspective Potential producing Protein provide reactive oxygen specy redox Redox imbalance Repair mechanisms resource ROS ROS—reactive oxygen species Signaling Specific Specy Stress syndrome therapeutic intervention treat [DOI] 10.3389/fcimb.2020.569709 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Capillary leakage provides nutrients and antioxidants for rapid pneumococcal proliferation in influenza-infected lower airways모세혈관 누출은 인플루엔자에 감염된 하기도에서 폐렴구균의 빠른 증식을 위한 영양소와 항산화제를 제공합니다.Article Published on 2020-12-082024-07-30 Journal: Microbial Cell Factories [Category] 폐렴구균 감염증, [키워드] antioxidants influenza A virus pneumococci Redox imbalance Streptococcus pneumoniae [DOI] 10.1073/pnas.2012265117 PMC 바로가기
The cholesterol metabolite 27-hydroxycholesterol inhibits SARS-CoV-2 and is markedly decreased in COVID-19 patientsResearch article Published on 2020-09-012022-10-05 Journal: Redox Biology [Category] SARS, 치료제, [키워드] 27-Hydroxycholesterol administration Antiviral caused cholesterol common cold control group coronavirus coronavirus SARS-CoV-2 Coronaviruses COVID-19 COVID-19 pandemic COVID-19 patient cytotoxicity disease HCoV-OC43 identify in vitro inhibit inhibitory activity marker metabolite no correlation Oxysterols physiological positive Redox imbalance reduction in SARS-CoV-2 Serum level severe COVID-19 severity shown significantly significantly increased Specific subject the disease variety viral pathogens worsening [DOI] 10.1016/j.redox.2020.101682 [Article Type] Research article