Wastewater to clinical case (WC) ratio of COVID-19 identifies insufficient clinical testing, onset of new variants of concern and population immunity in urban communitiesArticle Published on 2022-12-202022-11-16 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, [키워드] allelic Alpha variant anticipated Canada clinical clinical testing Community complement COVID-19 COVID-19 pandemic decrease Delta VOC diagnostic Effectiveness effort eligibility Endemic epidemiological Epidemiology greater identify Immunity in-depth analysis increases in infection control investigated Metrics occurred omicron Pandemics population immunity proportion public health Public-health reduction reduction in reported required resulting SARS-CoV-2 Seven significant decrease significant increases in significantly Surveillance the disease the SARS-CoV-2 variant variants of concern VoC wastewater wastewater surveillance Wastewater-based epidemiology. [DOI] 10.1016/j.scitotenv.2022.158547 PMC 바로가기
Intention to participate in COVID-19 vaccine clinical trials in May 2021: a cross-sectional survey in the general French populationArticle Published on 2022-11-302022-11-16 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI 95% confidence interval adjusted Attitude Attitudes Clinical research clinical trial conducted contribute COVID 19 COVID-19 COVID-19 vaccination COVID-19 vaccine cross-sectional cross-sectional survey Factor female gender France French Government Health healthcare worker immunization increase in Intention media new SARS-CoV-2 Participation predict reduction in risk severe COVID-19 Trial trial. vaccination Vaccine vaccine availability variant [DOI] 10.1080/21645515.2022.2072630 PMC 바로가기
Maternal SARS-CoV-2 sero-surveillance using newborn dried blood spot (DBS) screening specimens highlights extent of low vaccine uptake in pregnant womenArticle Published on 2022-11-302022-11-15 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Adults analyzed Antibody concentrations Antibody neutralization Blood complications contributing to COVID COVID-19 delta variant dose Dried blood spots fetal General population help highlight Hospital admissions Immunity IMPROVE information Intervention Maternal MONITOR natural infection Newborn newborn screening omicron outcomes pregnant women proportion reduction in representing Result SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 IgG antibodies serostatus specimen the SARS-CoV-2 the vaccine utility vaccination vaccination. Vaccine women [DOI] 10.1080/21645515.2022.2089498 PMC 바로가기
Reduced circulating FABP2 in patients with moderate to severe COVID-19 may indicate enterocyte functional change rather than cell deathArticle Published on 2022-11-052022-11-15 Journal: Scientific Reports [Category] SARS, 바이오마커, 진단, [키워드] acid Alter alteration Biomarker caused cell death change circulating Cohort contribute COVID-19 COVID-19 patient disease dysfunction Europe exclusion FABP2 functional Gut immune include increase in Infection Inflammation Inflammatory responses inhibited marker median metabolites microbial product Mild moderate NMR outliers pathology Patient patients with moderate plasma Plasma marker positive correlation reduced reduction in route of infection SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe disease severe group Severity of disease shown systemic [DOI] 10.1038/s41598-022-23282-x PMC 바로가기
Efficacy and safety of Treamid in the rehabilitation of patients after COVID-19 pneumonia: a phase 2, randomized, double-blind, placebo-controlled trialArticle Published on 2022-11-032022-11-16 Journal: Journal of Translational Medicine [Category] 비임상, [키워드] 1:1 Administered administration adverse event age Analysis animal model Anti-inflammatory assigned baseline Borg change changes in Chronic diseases clinical trial clinically COVID COVID pneumonia COVID-19 defined Diagnosis discharged double-blind Dyspnea Effect effective Efficacy Endpoint enrolled evaluated female female gender FEV first symptom FVC impairment increase in indicated Infection initial LLC lung damage Lung fibrosis Lung function Lungs mMRC moderate NCT04527354 offer past medical history Patient patients pharmacological treatment Placebo placebo group placebo-controlled clinical trial placebo-controlled trial Post-COVID rehabilitation predicted Prevent Primary outcome proportion pulmonary dysfunction pulmonary fibrosis Pulmonary function questionnaire Randomized Randomly reduction in Registered rehabilitation risk factor Russia SARS-CoV-2 secondary shown significant decrease significant difference stratified Support Symptoms Tolerability Treamid. Treatment Trial was done women [DOI] 10.1186/s12967-022-03660-9 PMC 바로가기
Antiviral potential of diminazene aceturate against SARS-CoV-2 proteases using computational and in vitro approachesArticle Published on 2022-11-012022-11-15 Journal: Chemico-biological interactions [Category] SARS, 치료제, [키워드] 3D structure ACE2 addition antiparasitic approach binding binding energy caused cleavage site COVID-19 Diminazene aceturate disease drug enzyme evaluate experimental model in silico in vitro in vivo inhibit Interaction M pro membrane molecular molecular docking molecular target Prevent processed promote protease Protein Protein Data Bank PyMol reduction in S1 and S2 SARS-CoV-2 SARS-CoV-2 protease SARS-CoV-2. spike receptor-binding domain stability targets tested viral replication virus infection was used [DOI] 10.1016/j.cbi.2022.110161 PMC 바로가기
Efficacy and safety of nitazoxanide in treating SARS-CoV-2 infection: a systematic review and meta-analysis of blinded, placebo-controlled, randomized clinical trialsArticle Published on 2022-11-012022-11-15 Journal: European Journal of Clinical Pharmacology [Category] SARS, 치료제, [키워드] 95% CI 95% confidence interval addition anti-inflammatory effect antiparasitic antiviral activity blinded clinical benefit continuous variable COVID-19 D-dimer D-dimer level death dichotomous variable Disease progression Effect effect size Efficacy and safety element eligibility enrolled Evidence Frequency ICU admission in vitro individual Inflammation Invasive mechanical ventilation lactate dehydrogenase LDH magnitude Meta-analysis Mild moderate Moderate COVID-19 nitazoxanide no difference Patient patients peer-reviewed performed Placebo placebo-controlled positive positive RT-PCR Primary outcome randomized clinical trial RCT RCTs receiving reducing reduction in reported risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection. secondary outcome serum biomarker SMD standardized mean difference systematic review tested to define treat treated Viral load WBC were used White blood cell with COVID-19 [DOI] 10.1007/s00228-022-03380-5 PMC 바로가기
Third dose of COVID-19 mRNA vaccine appears to overcome vaccine hyporesponsiveness in patients with cirrhosisArticle Published on 2022-11-012022-11-16 Journal: Journal of hepatology [Category] SARS, 변종, [키워드] 95% CI appear B.1.1.529 B.1.617.2 BNT BNT162b2 BNT162b2 mRNA booster booster dose chronic liver disease cirrhosis compensated Control control group COVD-19 COVID-19 COVID-19 in patient COVID-19 vaccines COVID-19-related death Critical dose doses General population greater hepatic decompensation hyporesponsiveness immune dysregulation liver magnitude moderate Moderate COVID-19 Moderna mRNA-1273 vaccine mRNA vaccine mRNA-1273 mRNA-1273. outcome overcome participant Patient Pfizer predominant receipt reduction in retrospective cohort study risk of infection Support symptomatic the vaccine Vaccine Vaccines variants veteran with COVID-19 [DOI] 10.1016/j.jhep.2022.07.036 PMC 바로가기
Decontamination Assessment of Nanofiber-based N95 MasksArticle Published on 2022-11-012022-11-16 Journal: Environmental science and pollution research inter [Category] 변종, [키워드] addition Aerosols assessment caused changes in decontamination dropped Efficiency electron microscopy emission equipment examined face Face masks Face masks, nanofibers field filtration filtration efficiency Health include management Mask Masks Microstructure morphological change morphology N95 mask N95 masks Novel coronavirus outbreak Pandemics Particle Personal protective equipment PPE pressure Pressure drop. reduction in Region scanning significantly Spread survivor ultraviolet UV light variant virus [DOI] 10.1007/s11356-022-20903-w PMC 바로가기
Successful Hepatitis C Birth Cohort Screening and Linkage to Care in a US Community Health SystemArticle Published on 2022-11-012022-11-15 Journal: Journal of Public Health Management and Practice [Category] 치료제, [키워드] analyzed antibody antiviral therapy Asymptomatic automated Birth birth cohort Care Cohort cohort of patient Community COVID-19 pandemic decrease diagnosed fibrosis had more HCV HCV antibody Health Hepatitis hepatitis C hepatitis C virus implementation Infection linkage maintenance more difficult multihospital system Patient patients positive Practice primary care reduction in RNA Screening significantly lower sustained System Treatment university virus were assessed [DOI] 10.1097/PHH.0000000000001590 PMC 바로가기