Regulated Intramembrane Proteolysis of ACE2: A Potential Mechanism Contributing to COVID-19 Pathogenesis?Immunology Published on 2021-06-072022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] ACE2 Amino acid angiotensin converting enzyme binding cellular cellular activation cleaved COVID-19 Critical domain ectodomain shedding endodomain cleavage expression Extracellular knowledge mapped MOST outcome phase 2 trial Potential preventative measure prophylactic treatment proteolysis proteolytic cleavage receptor regulated regulated intramembrane proteolysis SARS-CoV SARS-CoV infections SARS-CoV-2 SARS-COV-2 infection severe COVID-19 disease signaling molecule target the spike protein Treatment [DOI] 10.3389/fimmu.2021.612807 PMC 바로가기 [Article Type] Immunology
Designed Parasite-Selective Rhomboid Inhibitors Block Invasion and Clear Blood-Stage MalariaArticle Published on 2020-11-192024-08-28 Journal: Cell Chem Biol [Category] 말라리아, [키워드] apicomplexan parasites malaria Plasmodium presenilin Ras-converting enzyme regulated intramembrane proteolysis rhomboid protease serine protease site-2 protease. Toxoplasma