Deregulation of ceRNA Networks in Frontal Cortex and Choroid Plexus of Brain during SARS-CoV-2 Infection Aggravates Neurological Manifestations: An Insight from Bulk and Single-Cell Transcriptomic AnalysesSARS-CoV-2 감염 중 뇌의 전두엽 피질 및 맥락총 신경총에서 ceRNA 네트워크의 규제 완화는 신경 증상을 악화시킵니다: 대량 및 단일 세포 전사체 분석의 통찰력Article Published on 2022-08-012022-09-11 Journal: Advanced Biology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] analysis analyzed Brain cell type cell types choroid Choroid plexus competing competing endogenous RNA network cortex deregulated differentially expressed downregulated downregulation downstream excitatory explain Frontal Gene Expression help Human brain impairment indicated Initially insight landscape lncRNA MALAT1 mapping mechanism MIRLET7BHG miRNA miRNA. miRNAs mRNA NEAT1 network neurological Neuron neurons NorAD pathway enrichment Plexus reconstructed regulatory circuit RNA RNA-Seq SARS-CoV-2 single-cell RNA-seq STXBP5 STXBP5-AS1 therapeutic Therapeutics transcriptomic upregulated upregulation Variability [DOI] 10.1002/adbi.202101310 PMC 바로가기 [Article Type] Article
The promise of new anti-obesity therapies arising from knowledge of genetic obesity traits Reviews Published on 2022-07-282022-10-05 Journal: Nature Reviews Endocrinology [Category] 유전자 메커니즘, 진단, [키워드] affected arising benefit caused childhood complex defined disease driven by early-onset effect sizes environmental factors example Features form Genetic Genetic predisposition Genetic testing hyperphagia infancy Interaction involved knowledge MOST multifactorial obesity pathogenic variant pathway Patient patients with obesity pharmacological treatment Regulation regulatory circuit single gene syndrome therapy Treatment treatment approach variant [DOI] 10.1038/s41574-022-00716-0 [Article Type] Reviews
Single cell atlas for 11 non-model mammals, reptiles and birdsArticle Published on 2021-12-062022-10-04 Journal: Nature Communications [Category] SARS, 유전자 메커니즘, [키워드] ACE2 acute respiratory syndrome Analysis anatomical Animal physiology Cell Cell signalling co-expression conserved coronavirus Critical Cross-species transmission developmental Evolutionary developmental biology expression pattern Factor gene expression profile highlighting hosts identify investigated lung cell mammals molecular evolution provide regulatory circuit reservoirs reveal RNA sequencing SARS-CoV-2 SARS-CoV-2 entry factor single-cell target cell TMPRSS2 transcriptomics viral entry zoonotic [DOI] 10.1038/s41467-021-27162-2 PMC 바로가기 [Article Type] Article
nSARS-Cov-2, pulmonary edema and thrombosis: possible molecular insights using miRNA-gene circuits in regulatory networksResearch Published on 2020-10-302022-10-31 Journal: Exrna [Category] COVID-19, [키워드] accompany Antigen presentation antigen-presentation approach Cell coronavirus 2 Diseases disorder drugs edema Factor Features Feed forward loops FFLs identify Infection Inflammatory response information loop miRNA miRNA coregulatory networks molecular molecular mechanism motif nSARS-CoV-2 pandemic pathophysiology pathway pulmonary disease Pulmonary edema regulate regulatory circuit regulatory network Research respiratory Result Signaling signaling pathway signaling pathways similarity Spread symptomatic targets TGF the disease thromboembolic thrombosis trajectory unique vaccine candidate viral replication virus virus spike protein while [DOI] 10.1186/s41544-020-00057-y PMC 바로가기 [Article Type] Research
Proteomic profiling of the monothiol glutaredoxin Grx3 reveals its global role in the regulation of iron dependent processes모노티올 글루타레독신 Grx3의 단백질체 프로파일링은 철 의존적 과정의 조절에서 그것의 전체적인 역할을 보여줍니다Research Article Published on 2020-06-112022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affinity purification amplify applied approach associations biological processes Candida albican Candida albicans Cell cellular processes cofactor commensal component conserved Critical cytosolic determine DNA essential nutrient expression function functions fungal Gene Expression genotoxic glutaredoxin growth Grxs Heat shock histidine homeostasis Host human host humans in vivo interact iron iron homeostasis leucine maintain mass spectrometry metabolism mutant organism Organisms oxidative oxygen pathogen Pathogens performed Protein protein translation proteomic regulate Regulation regulatory circuit repair repression required respond reveal sulfur Support survival Taking target gene Target genes the cell Tryptophan utilization virulence [DOI] 10.1371/journal.pgen.1008881 PMC 바로가기 [Article Type] Research Article
Wor1 establishes opaque cell fate through inhibition of the general co-repressor Tup1 in Candida albicansWor1은 Candida albicans에서 일반적인 공동 억제 인자 Tup1의 억제를 통해 불투명한 세포 운명을 설정합니다.Research Article Published on 2018-01-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence Affect Affinity purification analyses analysis approach Author bypass Candida Candida albican Candida albicans carbon carbon source carbon sources Cell cell fate cells colonization colonize commensal complex protein explain expressed facilitate Factor function functions fungal Genetic gut microbiota Host identify individuals induce Loss maintain mass spectrometry mass spectroscopy master regulator mechanism molecular Morphological occur pathogen pathogenic phenotypic plasticity positive feedback promoter Proteins provide Region regulated Regulation regulatory circuit repression repressor serious infection serious infections stability starting switching temperature transcriptional transcriptional repressor undergo white Wor1 [DOI] 10.1371/journal.pgen.1007176 PMC 바로가기 [Article Type] Research Article
The Regulatory Network of Natural Competence and Transformation of Vibrio choleraeVibrio cholerae의 자연적 능력 및 변형의 규제 네트워크Research Article Published on 2012-06-212022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major Analysis aquatic bacterium aquatic environment assays Author autoinducers Bacteria Bacterial bacterium CAMP carbon Carbon catabolite repression catabolite repression Cell chitin chitinous chitinous exoskeleton colonization Combination competence condition conditions consequence contribute Degradation degradation products dependent on determine developmental different DNA ecological environmental niche environmental reservoirs Evidence Evolution Express expression pattern Extracellular Factor found Gene Gene Expression gene transfer Genes Genetic genetic transformation genomes growth heterogeneity heterogeneous homogeneous horizontal gene Horizontal gene transfer human pathogen immunological detection initiate intracellular signaling investigated involved lead maintenance majority metabolism mode natural Natural competence natural transformation network organism pathogenic phenotype protein level protein levels quantitative RT–PCR quorum-sensing pathways regions regulated regulatory circuit released reporter fusions required signaling cascade signaling pathway single cell level tested TfoX the cells transcriptional transfer transformation V. cholerae Vibrio cholerae western blot Western blot analysis zooplankton [DOI] 10.1371/journal.pgen.1002778 PMC 바로가기 [Article Type] Research Article