Are the Current Processes and Regulations Fit for Purpose to Deliver Novel Therapies During Pandemics? A Perspective on COVID-19 from the UKArticle Published on 2022-10-012022-11-16 Journal: Pharmaceutical medicine [Category] 신약개발, [키워드] activities adaptive approval arise contribute country COVID-19 COVID-19 pandemic current develop Dexamethasone ENhance flexible Health involved lesson Medicines multi-arm novel Pandemics question rare diseases RECOVERY trial reduce Regulation Regulatory regulatory pathways shown Stress therapy Trial trials UK Medicine United Kingdom urgency [DOI] 10.1007/s40290-022-00439-7 PMC 바로가기
Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics Reviews Published on 2022-08-022022-10-05 Journal: Signal Transduction and Targeted Therapy [Category] 치료제, [키워드] atherosclerotic atherosclerotic lesion benefit Cancer cancers cardiovascular disease cardiovascular diseases cardiovascular event cardiovascular system Cell cholesterol cholesterol homeostasis cholesteryl esters clinics Critical CVD diabetes disease Diseases Disturbed endothelial events Health inhibiting Intervention Lipid Low-Density Lipoprotein cholesterol maintaining mechanism molecular neurodegenerative nonalcoholic fatty liver obesity Osteoporosis pathway preclinical study Prevent PROTECT Regulation regulatory pathways Research shown target Transport Treatment virus infection [DOI] 10.1038/s41392-022-01125-5 [Article Type] Reviews
The transcription factor ZIP-1 promotes resistance to intracellular infection in Caenorhabditis elegansArticle Published on 2022-01-102022-10-04 Journal: Nature Communications [Category] 변종, 유전자 메커니즘, 치료제, [키워드] Activation Caenorhabditis Caenorhabditis elegan Control Defense downstream elegan ENCODE expressed function fungal pathogens Gene Expression Host Host transcriptional response hosts immune response induce infect Infection Infectious diseases Innate immunity intestinal intestinal cells intestine invertebrate less molecular Molecular biology nuclei pathogen promote Protective Protein regulatory pathways required resistance to infection RNA virus subset transcription factor Trigger virus [DOI] 10.1038/s41467-021-27621-w PMC 바로가기 [Article Type] Article
Access to and safety of COVID-19 convalescent plasma in the United States Expanded Access Program: A national registry study미국에서 Covid-19 회복기 혈장의 접근 및 안전성 확장 접근 프로그램 : 전국 레지스트리 연구Clinical Trial Published on 2021-12-202022-09-10 Journal: PLoS Medicine [Category] SARS, 신약개발, 임상, 진단, [키워드] 30-day mortality rate 95% CI access acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Administered affected age Analysis approval blood collection causative agent central institutional review board changes in characteristics of patient Clinical characteristics clinical trials convalescent plasma coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 convalescent plasma demographic demographic and clinical characteristics demographic group demographic groups early stage early stages effective effort eligible patient Eligible patients Emerging infectious disease enrolled Enrollment Evidence example Expanded access Expanded Access Program Factor framework Hispanic ethnicity hospital Hospitalized hospitalized patient hospitalized patients incidence include Inclusion increases in Infection infection rate Infectious disease initiated institutional review board investigated investigator less life-threatening Local majority male Mayo Clinic Metrics mortality rate National obesity observational study Older overweight Patient plasma populations potential therapeutic agents Pragmatic progression provided public health public health emergency Racial randomized clinical trial Region regions registry data regulatory pathway regulatory pathways required researcher respiratory resulting risk Safe safety profile SARS-CoV-2 Serious Adverse Event Serious Adverse Events severe acute respiratory syndrome Coronavirus Spread Stage Study design Temporal the United State The United States therapy transfused transfusion Treatment treatment effects Trial registration United State United States website while widespread with COVID-19 [DOI] 10.1371/journal.pmed.1003872 PMC 바로가기 [Article Type] Clinical Trial
Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoidArticle Published on 2019-01-312024-09-02 Journal: Clinical and Experimental Immunology [Category] 말라리아, 파상풍, [키워드] Cytokines Plasmodium regulatory pathways Submicroscopic infections Vaccines PMC 바로가기
Metatranscriptomic Study of Common and Host-Specific Patterns of Gene Expression between Pines and Their Symbiotic Ectomycorrhizal Fungi in the Genus SuillusSuillus 속의 소나무와 그 공생의 Ectomycorrhizal 균류 사이의 유전자 발현의 공통 및 숙주 특이적 패턴에 대한 Metatranscriptomic 연구Research Article Published on 2016-10-132022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptation Analysis association carbon coevolution common Comparative conserved dominant examined example exchange exhibited Express fitness FIVE function fungal fungi fungus G-protein gene-expression Genetic genetic regulation genetics genus group Host host-pathogen interaction host-pathogen interactions identify IMPROVE incompatible inoculated Interaction interactions investigated involved leucine mechanism Metatranscriptomic analysis microbial community pathogen pathogenic Pathways pattern Pinaceae pine plant plant roots Protein provide provided recognize Regulation regulatory pathway regulatory pathways response reveal RNA-Seq screened Signaling specificity symbiont Transcriptome transcriptomic unique [DOI] 10.1371/journal.pgen.1006348 PMC 바로가기 [Article Type] Research Article
Clinical Evaluation of Pertussis Vaccines: US Food and Drug Administration Regulatory Considerations백일해 백신의 임상 평가: 미국 식품의약국 규제 고려사항journal-article Published on 2014-04-012024-08-01 Journal: Nanoscale [Category] 백일해, [키워드] pertussis vaccines regulatory pathways vaccine effectiveness [DOI] 10.1093/infdis/jit532 [Article Type] journal-article
Principles of Carbon Catabolite Repression in the Rice Blast Fungus: Tps1, Nmr1-3, and a MATE–Family Pump Regulate Glucose Metabolism during Infection쌀 돌풍 곰팡이의 탄소 이화 작용 억제 원리: Tps1, Nmr1-3 및 MATE-Family 펌프가 감염 중 포도당 대사를 조절합니다Research Article Published on 2012-05-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] abolishes disease addition Agrobacterium tumefacien Agrobacterium tumefaciens Analysis Author BLAST carbon Carbon catabolite repression carbon metabolism carbon sources Catabolite catabolite repression CCR cell wall cell wall–degrading enzymes component components described disease downstream effective expression filamentous fungi found functional fungal fungal pathogens fungi Genetic genetic regulation Glucose glucose metabolism Glucose-6-phosphate Host identify inactivation Infection infection process inhibitor involved less M. oryzae Magnaporthe MATE protein MATE–family protein Mdt1 mechanism mediators metabolism microbial Mutagenesis Nmr1 Nmr1-3 Nmr1-3 inhibitor proteins nutrient availability organism Pathogenesis pathogenic pathogenicity Pathogens pathway Perturbation physiological principle Protein pump regulate Regulation Regulatory regulatory pathway regulatory pathways repression respond Rice shown sporulation strain sugar target Tps1 transcription factor transcriptional transmembrane Trigger triggers understanding [DOI] 10.1371/journal.pgen.1002673 PMC 바로가기 [Article Type] Research Article