Adverse Drug Events Associated With Remdesivir in Real-World Hospitalized Patients With COVID-19, Including Vulnerable Populations: A Retrospective Multicenter StudyOriginal Article Published on 2023-11-132024-09-05 Journal: Journal of Korean medical science [Category] update2024, [키워드] Coronavirus disease 2019 hepatic impairment Pregnancy Remdesivir renal impairment [DOI] 10.3346/jkms.2023.38.e346 PMC 바로가기 [Article Type] Original Article
The effect of renal impairment and obesity on anti-Xa peak and trough levels in patients receiving therapeutic doses of nadroparin: a comparison with control patientsarticle Published on 2023-09-142024-09-05 Journal: European Journal of Clinical Pharmacology [Category] update2024, [키워드] anti-Xa dose reduction LMWH Nadroparin obesity renal impairment [DOI] 10.1007/s00228-023-03558-5 PMC 바로가기 [Article Type] article
The Association of Baseline Plasma SARS-CoV-2 Nucleocapsid Antigen Level and Outcomes in Patients Hospitalized With COVID-19Article Published on 2022-10-012022-11-16 Journal: Annals of internal medicine [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI acute SARS-CoV-2 infection antibody Antigen baseline Biomarker body mass index Characteristics Clinical outcome clinically COVID-19 cross-sectional study delta variant discharge elevated ENhance enrolled Enrollment evaluate evaluated Factor Government greater higher odd hospital Hospital admission hospital discharge Hospitalized hospitalized patient hospitalized patients identify immunocompromising condition Infectious diseases Inpatient Laboratory less Level Logistic regression Male sex median Multiple multivariable N antigen nasal nasal swab Noninvasive ventilation Odds ratio operation outcome outcomes participant pathogenesis of COVID-19 pathogenesis of SARS-CoV-2 Patient patients with COVID-19 plasma Platform trial point-of-care polymerase chain predict quantification regression models Remdesivir renal impairment SARS-CoV-2 SARS-CoV-2 nucleocapsid severity speed Support Symptoms Therapeutics transcriptase viral replication was determined was measured were assessed worsened worsening [DOI] 10.7326/M22-0924 PMC 바로가기
Renin-angiotensin system blocker and the COVID-19 aggravation in patients with hypertension, diabetes, renal failure, Cerebro-cardiovascular disease, or pulmonary disease: Report by the COVID-19 Registry JapanObservational Study Published on 2022-10-012022-10-05 Journal: Journal of cardiology [Category] 임상, [키워드] ACEi/ARB acute respiratory syndrome Admission Analysis angiotensin-converting enzyme inhibitor ARB Associated factors association blocker chronic obstructive COPD coronavirus coronavirus disease correlation COVID-19 diabetes Diabetes Mellitus disease Disease outcome. Diseases enrolled extracorporeal membrane oxygenation Factor Female patients healthcare healthcare facility hypertension In-hospital death increased risk information intensive care Japan lower risk male Male sex outcome pandemic Patient patients positive Primary outcome Primary outcomes pulmonary disease receptor registry registry data renal renal impairment report risk severe COVID-19 severe renal impairment severity Support Treatment ventilator with COVID-19 [DOI] 10.1016/j.jjcc.2022.04.001 PMC 바로가기 [Article Type] Observational Study
Pharmacokinetics of Oral Nirmatrelvir/Ritonavir, a Protease Inhibitor for Treatment of COVID-19, in Subjects With Renal ImpairmentArticle Published on 2022-10-012022-11-15 Journal: Clinical Pharmacology and Therapeutics [Category] 치료제, [키워드] 24 hour adjusted Administered adverse event adverse outcome assessments Chronic kidney disease clearance coronavirus disease COVID-19 decrease dose dose reduction Effect eliminated evaluated exhibited geometric geometric mean ratio glomerular filtration rate group increased risk kidney laboratory measurements Mild mild in severity moderate Nirmatrelvir oral participant Patient patients with moderate pharmacokinetics Phase I plasma plasma concentration positively correlated progression reducing renal renal function renal impairment risk Ritonavir severe disease severe renal impairment systemic Tolerability vital signs [DOI] 10.1002/cpt.2688 PMC 바로가기
Lp-PLA2 as a biomarker and its possible associations with SARS-CoV-2 infection바이오마커로서의 Lp-PLA2 및 SARS-CoV-2 감염과의 가능한 연관성Review Published on 2022-07-012022-09-11 Journal: Biomarkers in Medicine [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] affected association Biomarker Biomarkers cardiovascular condition cardiovascular conditions chromosome chronic obstructive chronic obstructive pulmonary disease COVID-19 Economy enzyme estimation Evidence Exercise Tolerance healthy individuals help hepatic disease hour Inflammation life Lp-PLA2 management marker metabolic condition metabolic conditions obstructive pulmonary disease oxidative stress pathophysiological Pathways PLA2G7 pulmonary disease renal impairment risk SARS-COV-2 infection Serum level serum levels Sickness Signal transduction Tolerance Treatment [DOI] 10.2217/bmm-2021-1129 PMC 바로가기 [Article Type] Review
Impact of age on the efficacy and safety of peficitinib (ASP015K) for the treatment of rheumatoid arthritis류마티스 관절염 치료를 위한 페피시티닙(ASP015K)의 효능과 안전성에 대한 나이의 영향Clinical Trial Published on 2022-07-012023-06-01 Journal: Modern rheumatology [Category] 대상포진, 두창, 수두, 홍역, [키워드] elderly Janus kinase inhibitor Peficitinib renal impairment rheumatoid arthritis [DOI] 10.1093/mr/roab058 [Article Type] Clinical Trial
Early renal impairment is associated with in-hospital death of patients with COVID-19조기 신장 장애는 COVID-19 환자의 병원 내 사망과 관련이 있습니다.Article Published on 2022-06-012022-09-11 Journal: The clinical respiratory journal [Category] COVID19(2023년), SARS, 치료기술, [키워드] Admission age ALB albumin Blood blood cell blood platelet BNP Brain brain natriuretic peptide C-reactive protein Clinical management clinical manifestation Clinical outcome Cohort cohorts collected Complication coronavirus disease Coronavirus disease 2019 count COVID-19 COVID-19 patient creatine CRP determine diabetes diagnosed with COVID-19 early renal impairment EGFR erythrocyte sedimentation erythrocyte sedimentation rate ESR higher risk Hospitalization Hospitalized impairment In-hospital death incidence independent risk factor independent risk factors Laboratory lymphocyte Lymphocyte count Mortality nitrogen Patient patients patients with COVID-19 peptide Pneumonia prealbumin prognostic Proteinuria Record renal renal function renal impairment renal insufficiency risk stratification sedimentation rate serum significantly higher significantly lower Stratification Urine WBC White blood cell [DOI] 10.1111/crj.13496 PMC 바로가기 [Article Type] Article
RAGE has potential pathogenetic and prognostic value in nonintubated hospitalized patients with COVID-19RAGE는 삽관되지 않은 COVID-19 입원 환자에서 잠재적인 병리학적 및 예후적 가치가 있습니다.Clinical Trial Published on 2022-05-092022-09-11 Journal: JCI Insight [Category] MERS, 바이오마커, 임상, 진단, 치료법, [키워드] adjusted age Antibody Response Antigen association bamlanivimab baseline Biomarker Biomarkers BMI clinical Clinical outcome clinical outcomes Clinical practice clinical trial Concentration correlated correlation Corticosteroid corticosteroid treatment COVID-19 Cox regression CRP Cytokines diabetes Diabetes Mellitus enrolled Factor highest Hospitalized hospitalized patient hospitalized patients IL-6 Illness severity Indicator likelihood mechanically ventilated nucleocapsid antigen oxygen participant Participants patients with COVID-19 plasma positive Prognostic value Pulmonology quartile RAGE rate ratio receptor renal impairment risk of death Sex significantly lower Spearman supplemental oxygen sustained systemic inflammation tested Trial Viral viral burden Viral load was measured was used were used with COVID-19 [DOI] 10.1172/jci.insight.157499 PMC 바로가기 [Article Type] Clinical Trial
Repurposing Siddha mercurial drug for mild to moderate COVID-19 – Case series and exploration of its chemical profileCase report Published on 2022-04-012022-10-05 Journal: Journal of Ayurveda and Integrative Medicine [Category] 신약개발, [키워드] 1H-Imidazole 9,12-Octadecadienoic acid acute respiratory syndrome age Ayurveda body temperature Chemical profile Chest compounds coronavirus cough COVID-19 COVID-19 patients Drug discovery female Fever first dose Gas Chromatography-Mass Spectrometry home quarantine infected patient Inflammatory diseases kidney liver Liver function loss of taste male Mercury Mild moderate Moderate COVID-19 normalized oxygen saturation Pain parameter plasma positive renal function renal impairment repeated repurposing required Research RT-PCR Safe SARS-CoV-2 Siddha Side-effect Swab Symptom therapy Traditional medicine treat treated Treatment Vajra was done were assessed X-ray/CT [DOI] 10.1016/j.jaim.2021.06.009 [Article Type] Case report