Saliva molecular testing bypassing RNA extraction is suitable for monitoring and diagnosing SARS-CoV-2 infection in childrenRNA 추출을 우회하는 타액 분자 검사는 어린이의 SARS-CoV-2 감염 모니터링 및 진단에 적합Article Published on 2022-06-152022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] Accuracy addition affecting age antibody Asymptomatic bypassing children collected Community COVID-19 COVID-19 symptom Ct value Ct values diagnosing effective groups hospital IgM Infant Infants Infection investigated molecular nasopharyngeal NP swab Particle positive positive response qPCR test required rescue RNA extraction RT-qPCR test Saliva saliva sample saliva samples SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 variants sensitivity significantly specificity susceptible the mean threshold Vaccine Viral Viral RNA Viral transmission virus [DOI] 10.1371/journal.pone.0268388 PMC 바로가기 [Article Type] Article
CytoSorb Rescue for COVID-19 Patients With Vasoplegic Shock and Multiple Organ Failure: A Prospective, Open-Label, Randomized Controlled Pilot StudyRandomized Controlled Trial Published on 2022-06-012022-10-04 Journal: Critical Care Medicine [Category] 임상, [키워드] 1:1 95% CI adjusted Adsorption adverse event age Antibiotics Berlin C-reactive protein clinical concentrations control group Controlled COVID-19 COVID-19 patient COVID-19 patients cytokine dose Effect Endpoint enrolled excluded Gender greater groups hazard ratio Hemodialysis ICU IMPROVE inflammatory markers interleukin-6 interquartile range IQR junction measurement median membrane Monmouth Mortality mortality rate Multiple one patient Patient pilot study primary endpoint Prospective Randomized receive reduction Registered registry rescue Resolution secondary Secondary endpoints Shock Standard of care Standard therapy study inclusion the primary endpoint treatment group university hospital variable Withdrawal [DOI] 10.1097/CCM.0000000000005493 PMC 바로가기 [Article Type] Randomized Controlled Trial
Cytokine Hemoadsorption as Rescue Therapy for Critically Ill Patients With SARS-CoV-2 Pneumonia With Severe Respiratory Failure and HypercytokinemiaMedicine Published on 2022-01-102022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] “cytokine storm” acute respiratory distress syndrome (ARDS) All the patient analyzed benefit Berlin C-reactive protein Case series clinical response clinically coronavirus 2019 disease COVID-19 Critically ill patient cytokine cytokine removal D-dimer death dysregulated Europe evaluate failure ferritin Germany hemoadsorption high risk hypercytokinemia ICU identifying IL-6 Ill improvement in-hospital mortality inflammatory biomarkers Inflammatory response intensive care interleukin-6 Invasive mechanical ventilation organ dysfunction Oxygenation PaO pathophysiology Patient plasma Prone position prone positioning reduction in rescue respiratory Respiratory failure Retrospective study SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pneumonia severe respiratory failure significant difference single center SOFA score Therapies therapy Treatment with COVID-19 [DOI] 10.3389/fmed.2021.779038 PMC 바로가기 [Article Type] Medicine
Chinese Medicine Rescues Acute Respiratory Dyspnea Syndrome Caused by COVID-19: A Case Report한의학, COVID-19로 인한 급성 호흡곤란 증후군 구조: 증례 보고Case Reports Published on 2022-01-012022-09-11 Journal: Chinese journal of integrative medicine [Category] 치료제, [키워드] Chinese Medicine report rescue respiratory [DOI] 10.1007/s11655-021-3333-6 PMC 바로가기 [Article Type] Case Reports
Ambulatory care management of 69 patients with acute severe ulcerative colitis in comparison to 695 inpatients: insights from a multicentre UK cohort study695명의 입원 환자와 비교하여 급성 중증 궤양성 대장염 환자 69명의 외래 치료 관리: 영국 다기관 코호트 연구의 통찰력Multicenter Study Published on 2022-01-012022-09-11 Journal: BMJ open gastroenterology [Category] SARS, 치료기술, [키워드] acceptability age ambulatory Ambulatory care ambulatory patient ambulatory patients Analysis Aside bowel Care Cohort cohort study cohorts colectomy collected Corticosteroid COVID-19 criteria detect Diagnosis discharged disease disease phenotype Effectiveness Eligible patients evaluated flexible flexible sigmoidoscopy Follow-up Health Service health service research hospital Hospital admission hospital management hospitalised IBD IBD clinical index Inflammatory Inflammatory bowel disease intravenous less management Mortality multicentre no significant difference no significant differences outcome outcome measure Pathways Patient patients treated performed phenotype physician Post hoc analysis Primary outcome PROTECT readmission recruited registration number required rescue secondary secondary outcome Secondary outcomes Steroids Stool culture subsequent surgery surgery for IBD therapy Treatment Treatment outcome ulcerative colitis ulcerative colitis. used data [DOI] 10.1136/bmjgast-2021-000763 PMC 바로가기 [Article Type] Multicenter Study
Telehealth to the Rescue During COVID-19: A Convergent Mixed Methods Study Investigating Patients’ PerceptionPublic Health Published on 2021-11-302022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] analyses Analysis analyzed average benefit collected component COVID-19 COVID-19 pandemic Data integration dataset Dubai explained favor healthcare Healthcare quality improvement introduced joint joint display analysis Middle East Mixed methods North Occurrence pandemic participant participated Patient Patient satisfaction Perception principal Qualitative qualitative data Quantitative Quantitative data random Randomly Regional reliability rescue Satisfaction selected SPSS suggested teleconsultation telehealth the patient thematic analysis United Arab Emirate Value-based health care [DOI] 10.3389/fpubh.2021.730647 PMC 바로가기 [Article Type] Public Health
Case Report: Interferon- γ Rescues Monocytic Human Leukocyte Antigen Receptor (mHLA-DR) Function in a COVID-19 Patient With ARDS and Superinfection With Multiple MDR 4MRGN Bacterial StrainsImmunology Published on 2021-11-012022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, [키워드] Acinetobacter acute respiratory distress adaptive adaptive immune system antibiotic Antigen Antigen presentation ARDS Bacterial bacterial pathogen bloodstream boost carbapenem CD14+ monocyte Cefiderocol Cell Citrobacter complication of COVID-19 complications COVID-19 deficiency described discharge ECMO expressed expression expression level extracorporeal membrane oxygenation FACS analysis function HLA-DR hospital Human identify IFNγ immune Immune cell immune response Immune status immune system Immunity immunological synapse Immunosuppression indicated Infection interferon invasive isolate Klebsiella pneumoniae leukocyte lung MDR mHLA-DR monocyte multidrug-resistant Multiple outcomes Patient Pneumonia pneumoniae positive present antigen profile Pseudomonas aeruginosa rapid increase receptor regimen report rescue risk factor Secondary infection Sepsis septicemia severe immunosuppression severe pneumonia strain suggested superinfection Support suppressed syndrome the patient therapeutic therapy [DOI] 10.3389/fimmu.2021.753849 PMC 바로가기 [Article Type] Immunology
Exacerbation of immune thrombocytopenia following COVID-19 vaccination코로나19 백신 접종 후 면역 혈소판 감소증 악화Article Published on 2021-11-012022-09-12 Journal: British Journal of Haematology [Category] MERS, 진단, [키워드] Affect bleeding clinical symptom Corticosteroid COVID-19 COVID-19 vaccination Exacerbation had no immune Immune thrombocytopenia Intravenous immunoglobulin median occurred Patient patients Platelet post vaccination rescue Safety Symptom therapy Treatment vaccination vaccination. Vaccine vaccine dose worsening [DOI] 10.1111/bjh.17645 PMC 바로가기 [Article Type] Article
Natural Polyphenols as Immunomodulators to Rescue Immune Response Homeostasis: Quercetin as a Research Model against Severe COVID-19면역 반응 항상성을 구조하기 위한 면역 조절제로서의 천연 폴리페놀: 심각한 COVID-19에 대한 연구 모델로서의 케르세틴Review Published on 2021-09-252022-09-10 Journal: Molecules [Category] SARS, 치료제, [키워드] Adaptive immune response Analysis appearance approved asymptomatic infection autophagy broad spectrum caused China Chronic diseases clinical disease clinical trial collected COVID-19 COVID-19 pandemic COVID-19 pathogenesis Cytokines death develop driving dysregulated dysregulated immune response elicited Health Health crisis identify immune responses immunological mechanism immunomodulation immunomodulatory activity Immunomodulatory agent Immunomodulatory agents in vitro in vivo Inflammation Inflammatory response Lymphocytes macrophages mechanism Model natural Pathogenesis polyphenol polyphenols producing quercetin reducing rescue Research response SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severity Spread suggested therapeutic drug treat Vaccines [DOI] 10.3390/molecules26195803 PMC 바로가기 [Article Type] Review
Potential Therapeutic Effect of Micrornas in Extracellular Vesicles from Mesenchymal Stem Cells against SARS-CoV-2SARS-CoV-2에 대한 중간엽 줄기세포의 세포외 소포에서 Micrornas의 잠재적 치료 효과Article Published on 2021-09-122022-09-11 Journal: Cells [Category] SARS, 변종, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alter anti-SARS-CoV-2 anti-viral response binding cellular physiology complementary components conserved coronavirus COVID-19 Cytokine storm Cytopathic effect cytopathic effects differentiation Effect EVs expressed expression extracellular vesicle Extracellular vesicles FIVE human gene human genes immune response immune responses infected cell infected cells Infection inhibiting membrane-bound mesenchymal stem cell micro-RNA microenvironment miR-181a-5p miR-23a-3p miRNA miRNAs mRNAs mutated myriad nucleic acids peptides Potential Proinflammatory response proliferation Proteins Region regulate released rescue respiratory RNAs SARS-CoV-2 SARS-CoV-2 virus sequence severe acute respiratory syndrome Coronavirus STEM suppression tested therapeutic agent therapeutic agents UTR variant variety Vesicle vesicles Viral viral gene viral genome viral infection viral replication [DOI] 10.3390/cells10092393 PMC 바로가기 [Article Type] Article