Efficacy of Therapeutic Exercise in Reversing Decreased Strength, Impaired Respiratory Function, Decreased Physical Fitness, and Decreased Quality of Life Caused by the Post-COVID-19 SyndromeReview Published on 2022-12-152023-07-11 Journal: Viruses [Category] COVID19(2023년), [키워드] exercise fatigue Long COVID-19 physical fitness post-COVID-19 Quality of life Respiratory function SARS-CoV-2 [DOI] 10.3390/v14122797 PMC 바로가기 [Article Type] Review
Remdesivir Plus Dexamethasone Versus Dexamethasone Alone for the Treatment of Coronavirus Disease 2019 (COVID-19) Patients Requiring Supplemental O2 Therapy: A Prospective Controlled Nonrandomized Study코로나바이러스 질병 2019(COVID-19) 환자 치료를 위한 렘데시비르 플러스 덱사메타손 대 덱사메타손 단독 요법: 보충 O2 요법이 필요한 환자: 전향적 통제된 비무작위 연구Controlled Clinical Trial Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 임상, 치료제, [키워드] 30-Day mortality Antiviral baseline calculated clinical outcomes cohorts Combination Controlled coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient CRP D-dimer Dexamethasone drug effective Endpoint enrolled evaluate evaluated faster fibrinogen FiO2 group groups Hospitalization IMPROVE independent Inflammatory inflammatory markers Kaplan-Meier Kaplan-Meier curve Kaplan-Meier curves laboratory characteristics log-rank test median Mortality neutrophil neutrophil/lymphocyte ratio no differences occurred primary endpoint primary endpoints Prospective reducing mortality reduction in reduction in mortality Remdesivir Respiratory failure Respiratory function Sample size SARS-CoV-2 clearance secondary Secondary endpoints shown significant difference significant differences survival the log-rank test therapy treat Treatment viral clearance were used [DOI] 10.1093/cid/ciac014 PMC 바로가기 [Article Type] Controlled Clinical Trial
Pericardial Involvement in Severe COVID-19 PatientsObservational Study Published on 2022-08-122022-10-05 Journal: Medicina [Category] SARS, 임상, [키워드] Admission Arterial hypertension biochemical cardiac enzyme Cell CK-MB Coagulation parameters complete blood count complications computer tomography congestive heart failure COVID-19 COVID-19 complications enrolled evaluate evaluated form group identify in both group Increased inflammation markers Involvement LDH lung involvement material median age median value Mild moderate Mortality Myoglobin obesity objective Observational cohort study overall mortality parameters participant Patient patients percentage pericardial effusion Pericarditis presence of comorbidity Prevalence receptors recorded Respiratory function Result risk Risk factors SARS-CoV-2 serum parameters severe COVID-19 statistical significance statistically tissue tropism Type-2 diabetes mellitus [DOI] 10.3390/medicina58081093 PMC 바로가기 [Article Type] Observational Study
Efficacy and safety of the investigational complement C5 inhibitor zilucoplan in patients hospitalized with COVID-19: an open-label randomized controlled trialRandomized Controlled Trial Published on 2022-08-092022-10-04 Journal: Respiratory Research [Category] SARS, 임상, [키워드] 95% CI 95% confidence interval age Antibiotic prophylaxis assigned baseline Clinical outcome complement Complement 5 complement system Concentration control group COVID-19 COVID-19 patient Day Efficacy and safety Hypoxemia Inflammation inhibitor long-term follow up mean difference men Mortality MOST multicenter Odds ratio Open-label Oxygenation PaO Patient patients hospitalized primary analysis Primary outcome Randomized Randomized controlled trial randomized studies randomized trial Randomly receive Research Respiratory function serum Standard of care statistical significance systemic systemic inflammation the median Trial while zilucoplan [DOI] 10.1186/s12931-022-02126-2 PMC 바로가기 [Article Type] Randomized Controlled Trial
Defibrotide Therapy for SARS-CoV-2 ARDSClinical Trial Published on 2022-08-012022-10-04 Journal: Chest [Category] COVID19(2023년), SARS, 임상, [키워드] 95% CI Administered adverse event age all-cause mortality antiinflammatory Antithrombotic ARDS baseline bleeding Course COVID-19 D-dimer D-dimer level Day decrease defibrotide defibrotide. died dysregulation Endothelial dysfunction fibrinolytic Hemorrhagic high mortality rate initial limit management mechanical ventilation median median age occurred Older Open-label outcome parameter participant pathway Patient patient population patients died polymerase chain positive pulmonary disease Radiographic receiving reported Respiratory function Safe SARS-CoV-2 SARS-CoV-2 ARDS serum severe SARS-CoV-2 single-center survived therapy thrombotic complication Tolerability tolerable treated Trial vasopressor support [DOI] 10.1016/j.chest.2022.03.046 PMC 바로가기 [Article Type] Clinical Trial
Effect of body position on the redistribution of regional lung aeration during invasive and non-invasive ventilation of COVID-19 patientsObservational Study Published on 2022-06-302022-10-05 Journal: Scientific Reports [Category] 임상, 치료법, [키워드] acute respiratory distress Awake prone positioning benefit change COVID-19 patient dead distribution driven by Effect Electrical impedance tomography Endpoint evaluated fraction IMPROVE Intervention intrapulmonary invasive invasive ventilation invasively ventilated patient lung mechanical ventilation mechanism Non-invasive non-invasive ventilation Oxygenation parameter Patient performed primary endpoint prone Prone position prone positioning protocol reduced Respiratory function Respiratory system responsible secondary sensitivity severity Shunt significantly significantly increased Standard deviation Supine position syndrome Trial Ventilation ventilation-perfusion matching volumetric while zone [DOI] 10.1038/s41598-022-15122-9 PMC 바로가기 [Article Type] Observational Study
Pharmacological Studies in Hospitalized COVID-19 Patients in Belgium: We Could Do Better벨기에의 입원한 COVID-19 환자에 대한 약리학적 연구: 우리는 더 잘할 수 있습니다Review Published on 2022-06-292022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 임상, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive adaptive platform trials antivirals Belgian patient Belgium Better carried Clinical research Clinical studies clinical study clinical trial clinical trials collected collected data concerning coronavirus COVID-19 effective effort Enrollment evaluated help hospital Hospitalized hospitalized patient hospitalized patients hospitals identify immunomodulators IMPROVE International investigated less mono nitric oxide pandemic participated Patient patients with COVID-19 performed platform Randomized Registered Research Respiratory function Safe SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Therapeutics therapy treatments for COVID-19 Trial trials with COVID-19 [DOI] 10.3390/v14071427 PMC 바로가기 [Article Type] Review
Time-series analysis of multidimensional clinical-laboratory data by dynamic Bayesian networks reveals trajectories of COVID-19 outcomesResearch article Published on 2022-06-012022-10-05 Journal: Computer methods and programs in biomedicine [Category] COVID19(2023년), SARS, 바이오마커, [키워드] Admission Analysis applied Asymptomatic bacterial superinfection Bayesian Bayesian network cardiac damage Care case sery change clinical clinical condition collected conditions COVID-19 COVID-19 severity D-dimer level D-dimer levels Data analysis death demographics deteriorate died Dynamic Bayesian network Dynamic time warping expected Graphical model Hospital stay hospitalised In-hospital intensive care Italy kidney dysfunction Laboratory marker Mortality Most patient multidimensional objective outcome outcomes pathway Patient Probability procalcitonin raise Respiratory function Result retrospective reveal risk factor selected subsequent the patient those who survived thrombotic trajectory university variable variables worsening [DOI] 10.1016/j.cmpb.2022.106873 [Article Type] Research article
COVID-19 and neurological sequelae: Vitamin D as a possible neuroprotective and/or neuroreparative agentReview article Published on 2022-05-012022-10-05 Journal: Life sciences [Category] COVID19(2023년), SARS, 바이오마커, [키워드] ACE2 Affect association Atypical Brain canonical cell damage cellular Central nervous system consequence coronavirus COVID-19 COVID-19 pandemic Cytokines decrease deficiency Effect Effects enzyme etiological agent Evidence form function humans impairment Inflammation Invasion neurodegeneration Neuroinflammation neurological Neuropsychiatric Neuroreparation neutralize organ oxidative stress Pneumonia predisposition receptor regulate Respiratory function Respiratory system SARS-CoV-2 SARS-COV-2 infection Sequelae Vitamin D [DOI] 10.1016/j.lfs.2022.120464 [Article Type] Review article
Influence of socioeconomic status on functional recovery after ARDS caused by SARS-CoV-2: a multicentre, observational studyObservational Study Published on 2022-04-222022-10-05 Journal: BMJ Open [Category] COVID19(2023년), SARS, 임상, [키워드] acute respiratory distress alteration approved ARDS Berlin criteria Care caused Chest CT chest CT scan cohort study Compliance COVID-19 Critical Critical care defined Desaturation develop diagnosed discharge disease eligible Ethics facilitator finding Follow-up form functional Health healthcare High-flow nasal oxygen hospitalised ICU identify impair include Inclusion independent individual influence informed consent form initial Intensive intensive & intensive care International lung multicentre National outcomes oxygen Patient patients with COVID-19 peer-reviewed performed Primary outcome Prognosis protection protocol Pulmonary function tests Quality of life rehabilitation respiratory Respiratory function respiratory infections Respiratory Support risk SARS-COV-2 infection Severe case severity Study protocol syndrome [DOI] 10.1136/bmjopen-2021-057368 PMC 바로가기 [Article Type] Observational Study