Mucosal chemokine adjuvant enhances synDNA vaccine-mediated responses to SARS-CoV-2 and provides heterologous protection in vivo점막 케모카인 보조제는 SARS-CoV-2에 대한 synDNA 백신 매개 반응을 향상시키고 생체 내 이종 보호를 제공합니다Article Published on 2022-07-192022-09-11 Journal: Cell Reports Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjuvant approach CCL27 CD8 cell-mediated response Cell-mediated responses chemokine claimed coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Delta VOC DNA DNA plasmid DNA vaccine Efficacy ENhance Frequency Heterologous heterologous challenge humoral IFNγ immunogenicity immunological in vivo interferon gamma mucosa mucosal mucosal surface mucosal surfaces mucosal. pandemic Plasmid Protective provide respiratory respiratory mucosa response SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines significant effect Spike protein Spike-specific antibody T cell T cells unique Vaccine vaccine efficacy variants of concern Viral viral control VOCs wild-type [DOI] 10.1016/j.xcrm.2022.100693 PMC 바로가기 [Article Type] Article
Development of a physiological model of human middle ear epitheliumOriginal Research Published on 2021-09-182022-10-30 Journal: The Laryngoscope [Category] COVID-19, [키워드] acute infection Antimicrobial therapy Biological models cells changed children ciliated clinical implication complex conditions Culture develop development disease Diseases epithelial epithelial cell epithelial cell type goblet immunofluorescence immunohistochemistry in vivo lack Level media membrane Microscopy mucosal otitis otitis media otorhinolaryngologic diseases physiological polymerase chain positive reflect Research respiratory mucosa Result Safe SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 shown subtype susceptible the healthy translational transmission electron microscopy Treatment undergo Ventilated [DOI] 10.1002/lio2.661 PMC 바로가기 [Article Type] Original Research
Cutting Edge: Nucleocapsid Vaccine Elicits Spike-Independent SARS-CoV-2 Protective Immunity최첨단: 뉴클레오캡시드 백신은 스파이크 독립적인 SARS-CoV-2 보호 면역을 유도합니다Article Published on 2021-07-152022-09-11 Journal: Journal of immunology (Baltimore, Md. : 1950) [Category] MERS, SARS, 변종, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Adenovirus challenge concern coronavirus Coverage COVID-19 pandemic Cutting defined effector mechanisms epitope expressing focus hamster immune K18-hACE2 mice mice mucosa neutralize Neutralizing nucleocapsid protective immunity Protein rationale recall Receptor binding domain reduced respiratory respiratory mucosa response responsible SARS-CoV-2 SARS-CoV-2 vaccines severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Support T cell target the SARS-CoV-2 vaccination Vaccine vaccine immunity variants Viral Viral load weight loss [DOI] 10.4049/jimmunol.2100421 PMC 바로가기 [Article Type] Article
DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist스파이크 당단백질의 DC/L-SIGN 인식은 SARS-CoV-2 트랜스 감염을 촉진하고 글리코미메틱 길항제에 의해 억제될 수 있습니다Research Article Published on 2021-05-202022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, SARS, 바이오마커, [키워드] ACE2 antigen-presenting cells authentic SARS-CoV-2 virus capture Cell cell lines cell surface CLR CLRs Concentration COVID-19 pathogenesis DC-SIGN defined described dissemination Effectiveness ENhance entry receptor envelope protein evaluated event examined Factor Final glycan glycosylation Host identify immune cells immunomodulation IMPROVE Infection inhibited innate immune response Interaction involved L-SIGN Langerin lung tissue mechanism molecular monocyte Monocytes mucosa opens pandemic Pathogens promote Protein pseudovirus receptor receptors recognize respiratory respiratory mucosa SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2 spike protein SARS-CoV-2 virus SIGN spike spike glycoprotein Spike protein Spread T-lymphocytes target cell target cells tested the cell the SARS-CoV-2 These data trans transfer transmission rate unique Vero E6 VERO E6 cells Viral viral infection viral spike protein virus virus viruses while [DOI] 10.1371/journal.ppat.1009576 PMC 바로가기 [Article Type] Research Article
Cutting Edge: Mouse SARS-CoV-2 Epitope Reveals Infection and Vaccine-Elicited CD8 T Cell Responses최첨단: 마우스 SARS-CoV-2 에피토프, 감염 및 백신 유발 CD8 T 세포 반응 밝혀내Article Published on 2021-03-012022-09-11 Journal: Journal of immunology (Baltimore, Md. : 1950) [Category] SARS, 변종, 치료법, [키워드] Adenovirus CD8 CD8 T cell COVID-19 COVID-19 vaccine cross-reactivity Culture Cutting dominant elicited epitope Heterologous HLA-A HLA-A*02 hospitalized patient hospitalized patients human ACE2 human disease Humoral immunity Immunity immunization intranasal magnitude memory mice mouse mucosa PBMC peptide recombinant adenovirus respiratory mucosa response responses robust SARS-CoV-2 SARS-CoV-2 nucleoprotein severity Spike protein systemically T cell T cell response T cell responses transgenic mice vaccination vaccine-elicited T cell vector viral spike protein Viral variants [DOI] 10.4049/jimmunol.2001400 PMC 바로가기 [Article Type] Article
Microbiota Modulation of the Gut-Lung Axis in COVID-19COVID-19에서 장폐 축의 미생물총 조절Review Published on 2021-02-242022-09-11 Journal: Frontiers in Immunology [Category] MERS, 치료기술, 치료제, [키워드] addition administration Affect affected Anti-inflammatory axis bidirectional caused condition consequence correlated COVID-19 COVID-19 patients deaths deregulation diarrhea digestive Diversity duodenum Dysbiosis exacerbated Fecal sample fecal samples gastrointestinal system gastrointestinal tract gastrointestinal tracts Gut gut microbiota gut-lung axis Health Organization immune immune response immune responses increased mortality Infectious disease Inflammation Interaction intestinal involved lung Lungs manifestation Manifestations mechanism microbiota modulation mucosa mucosal mucous membrane mucous membranes nasopharyngeal oesophagus other respiratory infections pathologic persistence Probiotics Prolonged rectum Regulatory respiratory respiratory and gastrointestinal tracts respiratory infections respiratory mucosa Respiratory system SARS-CoV-2 SARS-CoV-2 clearance SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 stomach target the healthy Therapeutic approach therapy virus WHO World Health Organization [DOI] 10.3389/fimmu.2021.635471 PMC 바로가기 [Article Type] Review