Reversibility – Communicable Diseases Research

A New Approach to Drug Repurposing with Two-Stage Prediction, Machine Learning, and Unsupervised Clustering of Gene Expression

2 단계 예측, 기계 학습 및 유전자 발현의 감독되지 않은 클러스터링으로 약물 용도에 대한 새로운 접근 방식

Article

Published on 2022-06-012022-08-31
Journal: Omics : a journal of integrative biology
[Category] MERS, 신약개발, 유전자 메커니즘,

[키워드] Acetate affected alvocidib analyzed approach approximation big data bioinformatics BMS-387032 candidate Candidates characteristic clinical trial clinical trials Cluster Clusters Compound conditions Consistency Control COVID-19 pandemic Critical dermatomyositis develop dimension disease Diseases drug Drug development Drug discovery Drug efficacy Drug repurposing drug research and OMICS effective enrichment enrichment analysis examined expected expression pattern expression patterns followed by for inclusion function functions Gene Expression gene set enrichment analysis Health human diseases identify Inclusion Inclusion body inclusion body myositis Infectious disease Infectious diseases Innovation Intervention machine learning Machine learning. Manifold mitoxantrone myositis New offer pathway phorbol phorbol-12-myristate-13-acetate polymyositis prediction premise Probability projection repurposing Research reversed Reversibility targets Uniform variety vorinostat
[DOI] 10.1089/omi.2022.0026 PMC 바로가기 [Article Type] Article

Allergic shiners in a patient with cough-variant asthma: a case report

기침-변형 천식 환자의 알레르기 샤이너: 증례 보고

Case Reports

Published on 2022-05-282022-09-11
Journal: Journal of Medical Case Reports
[Category] 변종,

[키워드] Adults Affect allergic Allergic shiners Asthma baseline Case report cause Challenge test characterized Chest chest X-ray chronic Chronic cough classic Computed tomography coronavirus disease Coronavirus disease 2019 cough Cough-variant asthma. coughing Diagnosis disappearance example excessive use extreme eyelid General population hacking cough heliotrope rash High-resolution Hyperinflation initiated Laboratory test limits Methacholine mimicking neuronal pandemic parameters pathway Patient phenotype Physical examination positive presenting Pulmonary function test Rash resulting Reversibility sensitivity severity Symptom Treatment tree urge
[DOI] 10.1186/s13256-022-03423-6 PMC 바로가기 [Article Type] Case Reports

Similarities and differences in the conformational stability and reversibility of ORF8, an accessory protein of SARS-CoV-2, and its L84S variant

SARS-CoV-2의 보조 단백질인 ORF8과 그 L84S 변이체의 구조적 안정성과 가역성의 유사점과 차이점

Article

Published on 2021-07-232022-09-11
Journal: Biochemical and Biophysical Research Communication
[Category] SARS, 변종, 진단,

[키워드] acidic conditions acidic pH acute respiratory syndrome acute respiratory syndrome coronavirus analyzed cause Cell characteristic conformational coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 examined exhibited finding functional greater indicated L84S variant less Neutral nuclear nuclear magnetic resonance ORF8 ORF8 protein Physicochemical properties physicochemical property precipitated produced Protein Protein conformation protein stability purified respiratory reversed Reversibility room temperature SARS-CoV-2 SARS-CoV-2. severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 stability strain Structure suggested temperature Tobacco variant variants was used wild-type Δ382
[DOI] 10.1016/j.bbrc.2021.05.074 PMC 바로가기 [Article Type] Article

Applying a Precautionary Approach to Mobile Contact Tracing for COVID-19: The Value of Reversibility

Symposium: COVID-19

Published on 2020-08-252022-10-29
Journal: Journal of bioethical inquiry
[Category] Coronavirus, MERS, SARS,