Risk Stratification for Hepatitis B Virus Reactivation in Kidney Transplant Recipients With Resolved HBV InfectionArticle Published on 2023-04-132023-06-13 Journal: Transplant International [Category] B형 간염, [키워드] antiviral therapy hepatitis B Immunosuppression Renal transplantation reversion [DOI] 10.3389/ti.2023.11122 PMC 바로가기
Analysis of entire hepatitis B virus genomes reveals reversion of mutations to wild type in natural infection, a 15 year follow-up studyArticle Published on 2022-01-012023-06-11 Journal: Infection, genetics and evolution : journal of mol [Category] B형 간염, [키워드] Evolution Hepatitis B virus Mutation Next-generation sequencing reversion [DOI] 10.1016/j.meegid.2021.105184
Scalable live-attenuated SARS-CoV-2 vaccine candidate demonstrates preclinical safety and efficacy확장 가능한 약독화 생 SARS-CoV-2 백신 후보, 전임상 안전성 및 효능 입증423 Published on 2021-07-202022-09-12 Journal: Proceedings of the National Academy of Sciences of [Category] Coronavirus, SARS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus added addition administration Amino acid amino acid sequence antibody antigenic antigenic drift approach Brain clinical development clinical testing codon deoptimization combating component condition conditions coronavirus COVID-19 COVID-19 pandemic deleted dose Effect Efficacy emerging disease engage feasibility furin furin cleavage site furin cleavage site deletion hamster hamsters herd immunity host immune system IgG antibody Immunity immunization in vitro in vivo model inoculated intranasal intranasally live attenuated Live virus lung Lung pathology mass immunization mass vaccination Mesocricetus mutations parental plaque reduction neutralization potency Protective recipients reduced reversion SARS-CoV-2 SARS-CoV-2 vaccine segment sequence Significance silent spike IgG Spike protein Support synonymous Syrian golden hamster Syrian Golden hamsters temperature temperature sensitive the spike protein the vaccine undetectable vaccination Vaccine vaccine candidate vaccine candidates vaccine strain viral genome Viral load Viral protein Viral proteins viral spike protein viral titers virus virus growth weight loss wild-type WT virus [DOI] 10.1073/pnas.2102775118 PMC 바로가기 [Article Type] 423
Reversion of Gut Microbiota during the Recovery Phase in Patients with Asymptomatic or Mild COVID-19: Longitudinal StudyArticle Published on 2021-06-072022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] 16S rRNA Amplicon sequencing applied Asymptomatic Bacteroidetes changed COVID-19 determine Effect FB ratio Fecal sample Gastrointestinal symptom Gut gut microbiota healthy controls Infection intestinal longitudinal longitudinal analysis microbe Microbiome Mild Modifying Negative conversion Patient patients with asymptomatic phase profile reported respiratory infection respiratory symptoms reversion SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV2 selected significantly increased therapeutic Viral RNA was performed with COVID-19 [DOI] 10.3390/microorganisms9061237 PMC 바로가기 [Article Type] Article
Thymosin Alpha 1 Reduces the Mortality of Severe Coronavirus Disease 2019 by Restoration of Lymphocytopenia and Reversion of Exhausted T Cells티모신 알파 1은 림프구 감소증의 회복과 소진된 T 세포의 회복을 통해 심각한 코로나바이러스 질병 2019의 사망률을 감소시킵니다Article Published on 2020-11-192022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] (PD-1 Alpha benefit Blood CD4+ T cell CD4+ T cells CD4+ T-cell CD8+ CD8+ T cell CD8+ T cells circulation clinical benefit clinical benefits Clinical outcome clinical outcomes conditions COVID-19 COVID-19 patient COVID-19 patients domain elderly patients expression flow cytometry hospital immune immune reconstitution immune response Immunoglobulin Infection less lymphocytopenia marker mechanism mononuclear cell mononuclear cells Mortality mucin Patient PD-1 Peripheral blood Peripheral blood mononuclear cells protein 3 reduced respiratory restoration restored reversed reversion SARS-CoV-2 Severe acute respiratory syndrome severe COVID-19 severe COVID-19 patient severe COVID-19 patients significantly T cell T cells T-cell T-cell exhaustion T-cell receptor thymosin thymosin alpha 1 Treatment treatment for COVID-19 Viral viral infection viral infections was measured Wuhan Wuhan, China [DOI] 10.1093/cid/ciaa630 PMC 바로가기 [Article Type] Article
Predominance of positive epistasis among drug resistance-associated mutations in HIV-1 proteaseHIV-1 프로테아제의 약물 내성 관련 돌연변이 중 양성 상위성의 우세Research Article Published on 2020-10-212022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] alleviate antiretroviral drug antiretroviral drugs Author capture clinic clinical observation clinical observations Clinical studies clinical study clinically Combination combinations compensatory mutations deep sequencing Deleterious deleterious effect deleterious effects drug drug resistance Effect epistasis Evolution fitness Genetic genetic interactions greatly reduce HIV HIV-1 Impact in vitro inhibitors Interaction interactions involved likelihood long term majority mechanism mutant Mutation mutations observation outcome overcome pandemic patients persistence positive Prophylaxis protease Protease inhibitor protease inhibitors reduce Replication resistance mutations reversal reversion selection experiments sequence Support T cells therapy Viral viral genome viral replication [DOI] 10.1371/journal.pgen.1009009 PMC 바로가기 [Article Type] Research Article
Broad antifungal resistance mediated by RNAi-dependent epimutation in the basal human fungal pathogen Mucor circinelloides기초 인간 곰팡이 병원체 Mucor circinelloides에서 RNAi 의존성 후성 돌연변이에 의해 매개되는 광범위한 항진균제 내성Research Article Published on 2019-02-112022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptation Analysis antifungal agent antifungal agents antifungal drug resistance cause clinically demonstrated develop drug drug resistance drug target drugs enzyme Enzymes Evolution FK506 fungal Fungal infection fungi Genes high mortality IMPROVE induce Infection mechanism Mucor Mucormycosis Mutation novel passage pathogen Pathogenesis Proteins Rapamycin resistance mechanism response restored reversion RNA RNA expression RNA interference RNAi RNAi pathway selected sensitivity small RNA sRNA strain target gene treat Treatment variety [DOI] 10.1371/journal.pgen.1007957 PMC 바로가기 [Article Type] Research Article
Quantitative multiplex one-step RT-PCR assay for identification and quantitation of Sabin strains of poliovirus in clinical and environmental specimensarticle Published on 2018-09-302024-09-01 Journal: Journal of Virological Methods [Category] 폴리오, [키워드] mucosal immunity Multiplex analysis Poliovirus surveillance reversion Virus shedding [Article Type] article
Pressure for Pattern-Specific Intertypic Recombination between Sabin Polioviruses: Evolutionary Implications사빈 폴리오바이러스 간의 패턴 특정 이형 재조합에 대한 압력: 진화적 함의Article Published on 2017-11-222024-08-01 Journal: Viruses [Category] 폴리오, [키워드] attenuation reversion Vaccine-derived polioviruses vaccine-induced adverse reactions virulence [DOI] 10.3390/v9110353 PMC 바로가기 [Article Type] Article
Proofreading-Deficient Coronaviruses Adapt for Increased Fitness over Long-Term Passage without Reversion of Exoribonuclease-Inactivating MutationsResearch Article Published on 2017-11-072022-10-29 Journal: mBio [Category] Coronavirus, MERS, [키워드] accounted adaptive evolution amino acid change catalytic competitive fitness coronavirus CoV cultured cell demonstrated disrupt Exoribonuclease explained fitness function Genotype Hypothesis Increased less MHV murine hepatitis virus mutant mutant virus Mutation mutations nonstructural protein 14 Nsp12 nsp14 nsp14-ExoN nucleoside analogue Nucleoside analogues passage phenotype plus-strand RNA virus Proofreading Protein reduced Replication replication fidelity residue responsible reversion RNA genome RNA synthesis RNA virus RNA viruses RNA-dependent RNA polymerase SARS-CoV selected single-stranded positive-sense stability Support susceptibility susceptible virulence wild-type yielding [DOI] 10.1128/mBio.01503-17 PMC 바로가기 [Article Type] Research Article