Annual two-dose tetanus toxoid vaccination induces protective humoral immunity to all age groups of rhesus macaques연간 두 번의 파상풍 독소 백신 접종은 모든 연령대의 롱테일 원숭이에 대한 보호성 체액 면역을 유도합니다.Article Published on 2023-11-092024-08-19 Journal: Experimental Animals [Category] 파상풍, [키워드] Antibody Response Clostridium tetani rhesus macaques Tetanus tetanus toxoid vaccine.
mRNA-1273 vaccination protects against SARS-CoV-2-elicited lung inflammation in nonhuman primatesmRNA-1273 백신 접종은 비인간 영장류에서 SARS-CoV-2 유발 폐 염증으로부터 보호합니다Article Published on 2022-07-082022-09-11 Journal: JCI Insight [Category] COVID19(2023년), SARS, 변종, [키워드] 48 hour 48 hours Antibody Response Antibody responses Antibody titer Bronchoalveolar lavage fluid CCL3 cellular Cellular immune response chemokines collected correlated COVID-19 CXCL10 dissemination dose-dependent manner expression Genes Human IFIT1 immune immunology independent induction Inflammation Inflammatory ISG15 less limit Lower respiratory tract lung Lung inflammation mRNA mRNA-1273 MX1 observation Pathogenesis profile PROTECT replicated respiratory tract restrict viral replication rhesus macaque rhesus macaques SARS-CoV-2 SARS-CoV-2 antibody response SARS-CoV-2 antibody responses SARS-CoV-2 spike SARS-CoV-2 strain serum Support suppressed These data transcriptomic USA-WA1/2020 vaccination Vaccine-induced immunity variant of SARS-CoV-2 viral infection viral replication Viral RNA [DOI] 10.1172/jci.insight.160039 PMC 바로가기 [Article Type] Article
Exposure modality influences viral kinetics but not respiratory outcome of COVID-19 in multiple nonhuman primate species노출 방식은 여러 비인간 영장류 종에서 바이러스 역학에 영향을 미치지만 COVID-19의 호흡기 결과에는 영향을 미치지 않습니다Article Published on 2022-07-052022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 변종, [키워드] aerosol exposure African African green monkeys AGM AGMs animal model animal models ARDS change Characteristics Chlorocebus clinical clinical response Clinical sign Clinical signs Cohort conserved COVID-19 COVID-19 disease cytokine response demonstrated demonstration develop expand exposure functional greater include infected with SARS-CoV-2 Infection influence intranasal lack lung damage magnitude Medical countermeasures mucosal mucosal exposure myeloid cell Novel coronavirus novel coronavirus SARS-CoV-2 outcome pandemic status Pathogenesis Pathologies pleuritis Pulmonary pathology reached regenerative Research rhesus rhesus macaques route SARS-COV-2 infection severe disease small particle aerosol species tested therapeutic utility variants variants of concern viral kinetics Viral load [DOI] 10.1371/journal.ppat.1010618 PMC 바로가기 [Article Type] Article
A modified vaccinia Ankara vaccine expressing spike and nucleocapsid protects rhesus macaques against SARS-CoV-2 Delta infection스파이크와 뉴클레오캡시드를 발현하는 변형된 백시니아 앙카라 백신은 SARS-CoV-2 Delta 감염으로부터 붉은털 원숭이를 보호합니다Article Published on 2022-06-242022-09-11 Journal: Science Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] added Beta Beta variant binding Blood CD4 CD8 T cell correlated cross-reactive cross-reactive antibody Delta delta variant Efficacy elicited expressed expressing FCS function furin furin cleavage site Heterologous homologous human ACE2 humoral IgG inactivated inactivation induce Infection intramuscular less lung mice moderate neutralized Neutralizing Neutralizing antibodies neutralizing antibody non-neutralizing antibody nose nucleocapsid positively correlated PROTECT rectum response rhesus macaque rhesus macaques robust SARS-CoV-2 SARS-CoV-2 vaccines secretion serum spike spike-specific IgG T cell T cell response T cell responses tested the SARS-CoV-2 vaccination Vaccine variant variants of concern virus VoC VOCs [DOI] 10.1126/sciimmunol.abo0226 PMC 바로가기 [Article Type] Article
Low-dose self-amplifying mRNA COVID-19 vaccine drives strong protective immunity in non-human primates against SARS-CoV-2 infectionArticle Published on 2022-06-072022-10-04 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome benefit boost cellular clinical trial convalescent coronavirus coronavirus disease COVID-19 COVID-19 vaccine dose doses driving effective vaccine Efficacy evaluated geometric mean titer GMT greater Heterologous highlighting homologous human sera humoral immune response immune response immunize low dose lower airways mice mRNA mRNA vaccine NAb neutralizing antibody non-human primate non-human primates offer pandemic populations prefusion prime-boost regimen Protective protective immunity provided reduction regimen regimens replicate rhesus macaque rhesus macaques RNA vaccines Safe SAM SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine spike glycoprotein Spread T cell response tested Translational immunology vaccination Vaccine viral replication [DOI] 10.1038/s41467-022-31005-z PMC 바로가기 [Article Type] Article
Modeling explains prolonged SARS-CoV-2 nasal shedding relative to lung shedding in remdesivir-treated rhesus macaquesResearch article Published on 2022-05-252022-10-05 Journal: iScience [Category] 비임상, [키워드] blunting cells clinical trials decrease explain FIVE Hospitalization hospitalized patient increases in Infection innate immune response intensity lung lung damage lung viral load Lungs mathematical modeling Molecular modeling nasal nasal passage nasal passages occur Pneumonia prevented raise reducing reduction in Remdesivir rhesus macaque rhesus macaques SARS- CoV-2 SARS-CoV-2 shedding relative therapy Viral load viral loads Virology [DOI] 10.1016/j.isci.2022.104448 [Article Type] Research article
Circular RNA vaccines against SARS-CoV-2 and emerging variantsSARS-CoV-2 및 신흥 변종에 대한 원형 RNA 백신Article Published on 2022-05-122022-09-11 Journal: Cell [Category] COVID19(2023년), MERS, SARS, 변종, 비임상, 진단, [키워드] Antigen booster circRNA vaccine Circular circular RNA COVID-19 Delta delta variant dose effective elicited expressing immune responses mice mRNA mRNA vaccine Neutralizing antibodies neutralizing antibody offer omicron proportion rhesus macaques RNA RNA vaccine robust SARS-CoV-2 Spike protein T cell T cell response T cell responses Th1-skewed immune responses the spike protein trimeric RBD vaccination Vaccine variant variant of concern variants of concern variants of SARS-CoV-2 VOCs worldwide pandemic [DOI] 10.1016/j.cell.2022.03.044 PMC 바로가기 [Article Type] Article
Prime-boost vaccination regimens with INO-4800 and INO-4802 augment and broaden immune responses against SARS-CoV-2 in nonhuman primatesINO-4800 및 INO-4802를 사용한 프라임-부스트 백신 요법은 비인간 영장류에서 SARS-CoV-2에 대한 면역 반응을 증대 및 확대합니다.Article Published on 2022-05-092022-09-11 Journal: Vaccine [Category] Coronavirus, COVID19(2023년), SARS, 변종, 비임상, [키워드] ACE2 Antibody Response Antibody responses blocking activity Booster vaccine booster vaccines characterized clinical evaluation COVID-19 DNA DNA vaccine Electroporation evaluated expansion homologous or heterologous immune evasion immune response Immunity immunogenicity INO-4800 Intradermal macaque natural infection Neutralizing pandemic portion question regimen regimens rhesus macaque rhesus macaques SARS-CoV-2 SARS-CoV-2 sequence SARS-CoV-2 variant SARS-CoV-2 variants shifting Strains Support T cell T cells These data Transmissibility vaccination Vaccine variant variants of concern wild-type SARS-CoV-2 Wuhan-Hu-1 [DOI] 10.1016/j.vaccine.2022.03.060 PMC 바로가기 [Article Type] Article
Ultrasensitive detection and quantification of viral nucleic acids with Raindance droplet digital PCR (ddPCR)Raindance droplet 디지털 PCR(ddPCR)을 사용한 바이러스 핵산의 초고감도 검출 및 정량화Article Published on 2022-05-012022-09-11 Journal: Methods (San Diego, Calif.) [Category] COVID19(2023년), SARS, 치료기술, [키워드] animal models Antiretroviral therapy approaches assays caused Cell Combination cure Cure research ddPCR detect Detection sensitivity diagnosis and monitoring digital PCR disease DNA and RNA Efficacy example highlighting HIV HIV prevention HIV-1 HIV-1 infection HIV-1 viral immunodeficiency virus infected individual infected individuals Infection Infectious disease Infectious diseases inhibition inhibitors Interpretation model systems NHP non-human primate nucleic acid Nucleic acid detection nucleic acids outcome platform predictor progression quantification quantitation Raindance reduced required Research reverse transcription rhesus macaque rhesus macaques RNA RT-ddPCR SARS-CoV2 sensitive Simian simian immunodeficiency virus SIV step tissue tissues Treatment treatment intervention treatment interventions viral DNA viral nucleic acid viral nucleic acid detection viral nucleic acids Viral reservoir virus viruses [DOI] 10.1016/j.ymeth.2021.04.025 PMC 바로가기 [Article Type] Article
Rational Development of a Polysaccharide-Protein-Conjugated Nanoparticle Vaccine Against SARS-CoV-2 Variants and Streptococcus pneumoniaeSARS-CoV-2 변이체 및 폐렴 연쇄상 구균에 대한 다당류-단백질-접합 나노입자 백신의 합리적인 개발Article Published on 2022-05-012022-09-11 Journal: Advanced Materials (Deerfield Beach, Fla.) [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 폐렴구균 감염증, [키워드] Against backbone capsular capsular polysaccharide caused Cellular immune response cellular immune responses chemical conjugation clinical evaluation COVID-19 COVID-19 pandemic cross-neutralize death development Diseases domain exhibit Final helper cell highlighting humoral immune responses immunization induce Infection Infectious diseases mice Mortality mouse-adapted strain murine models nanoparticle nanoparticle vaccines omicron other infectious diseases polysaccharide potency Prevent RATs RBD Receptor binding domain rhesus macaques S. pneumoniae S. pneumoniae serotype type 14 SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant serotype serum Spike protein Streptococcus pneumoniae Support T helper cell the SARS-CoV-2 thermal stability Type vaccination Vaccine vaccine platform variant VOCs [DOI] 10.1002/adma.202200443 PMC 바로가기 [Article Type] Article