Evaluation and Immunogenicity of Combined Liposome-Based Vaccine Candidates against Hepatitis E and B Viruses in Rhesus MonkeysArticle Published on 2024-01-052024-09-05 Journal: Vaccines [Category] update2024, [키워드] hepatitis B hepatitis E liposomes neutralizing epitope/s Rhesus monkeys small envelope vaccine candidates [DOI] 10.3390/vaccines12010053 PMC 바로가기 [Article Type] Article
Ultrasensitive monitoring of SARS-CoV-2-specific antibody responses based on a digital approach reveals one week of IgG seroconversionArticle Published on 2022-12-012022-11-15 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] addition antibodies Antibody Response approach AUC collected COVID-19 COVID-19 patient diagnostic diagnostics Donor Extreme early-stage seroconversion faster flow cytometry healthy IgG IgG and IgM IgG/IgM antibodies IgM immunoassay immunoassays immunological inactivated nucleic acid nucleic acids other diseases pathogen-specific Patient peptide platform probe Protein RBD reveal Rhesus monkeys SARS-CoV-2 S2 sensitivity Seroconversion seroconversion time Simoa tested Ultrasensitive digital detection. vaccination virus wild-type [DOI] 10.1016/j.bios.2022.114710 PMC 바로가기
Novel application of [18F]DPA714 for visualizing the pulmonary inflammation process of SARS-CoV-2-infection in rhesus monkeys (Macaca mulatta)Article Published on 2022-09-012022-11-16 Journal: Nuclear medicine and biology [Category] COVID19(2023년), SARS, 치료기술, [키워드] Activation added BAL Blood Bronchoalveolar lavage Chest COVID-19 dendritic cell determine diagnostic increased expression Infection infection process Inflammation initial injection lesions lung lung tissue Lymph node marker nonhuman primates novel performed pet PET-CT positive post infection principal pulmonary pulmonary inflammation pulmonary lesion pulmonary lesions Rhesus monkey Rhesus monkeys SARS-CoV-2 Seven Swab swabs timepoint TSPO TSPO. viral respiratory infections [DOI] 10.1016/j.nucmedbio.2022.05.002 PMC 바로가기
Three doses of prototypic SARS-CoV-2 inactivated vaccine induce cross-protection against its variants of concern프로토타입 SARS-CoV-2 비활성화 백신의 3회 용량은 우려되는 변이체에 대한 교차 보호를 유도합니다Article Published on 2022-02-252022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Alpha anal swabs Beta COVID-19 cross-protection Delta dose evaluate Experimental models of disease extension followed by geometric mean geometric mean titer GMT in vivo Inactivated vaccine induce Infectious diseases lung nasal Neutralizing antibodies neutralizing antibody omicron Omicron variants pandemic pathological change pathological changes Prevention and control produced reduced Rhesus monkey Rhesus monkeys SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant tissues Vaccine variant variants variants of concern Viral Viral load viral loads VoC VOCs [DOI] 10.1038/s41392-022-00920-4 PMC 바로가기 [Article Type] Article
A Comparative Study of Chest CT With Lung Ultrasound After SARS-CoV-2 Infection in the Assessment of Pulmonary Lesions in Rhesus Monkeys ( Macaca Mulatta )Veterinary Science Published on 2021-10-292022-11-01 Journal: Frontiers in Veterinary Science [Category] COVID-19, [키워드] abnormality assessment blinded Comparative Complete Computed tomography correlation COVID-19 CT findings Diagnosis diagnostic diagnostic value Diseases Efficacy female GGO GGOs Ground glass opacity Hospitalized humans infected with SARS-CoV-2 lesion Longitudinal assessment lung lung lobe Lungs macaques mild-to-moderate disease Monkey MOST non-human primate (NHP) Non-invasive nose/throat swab PCR positive post infection pulmonary Rhesus monkey Rhesus monkeys SARS-CoV-2 SARS-CoV-2 infected patients SARS-COV-2 infection scored sensitivity Ultrasound Volume [DOI] 10.3389/fvets.2021.748635 PMC 바로가기 [Article Type] Veterinary Science
Effects of buprenorphine/lorcaserin mixtures on preference for heroin, cocaine, or saline over food using a concurrent choice procedure in rhesus monkeysResearch article Published on 2021-10-012022-10-05 Journal: Drug and alcohol dependence [Category] 비임상, [키워드] Adding administration Alter attenuate Buprenorphine chose Critical Daily decrease disorder drug Effect effective Effectiveness Epidemic investigated less Lorcaserin medication medications offer Opioid use disorder outcome pharmacological preclinical studies Prevalence receptor reduced Result Rhesus monkey Rhesus monkeys selective Substance use Treatment Variability [DOI] 10.1016/j.drugalcdep.2021.108991 [Article Type] Research article
Self-Assembling Nanoparticle Vaccines Displaying the Receptor Binding Domain of SARS-CoV-2 Elicit Robust Protective Immune Responses in Rhesus MonkeysSARS-CoV-2의 수용체 결합 도메인을 표시하는 자가 조립 나노입자 백신은 붉은털 원숭이에서 강력한 보호 면역 반응을 이끌어냅니다Article Published on 2021-05-192022-09-11 Journal: Bioconjugate chemistry [Category] SARS, 비임상, 진단, [키워드] Analysis Antigen benefit breath candidate vaccine caused Cell Clinical trial design COVID-19 pandemic cross-neutralize domain effective effective vaccine Efficiency elicit eukaryotic expression ferritin Focusing Humoral immunity immune response immunization immunization program immunized Infection inhibited isolates Monkey nanoparticle nasal Neutralizing antibodies neutralizing antibody new SARS-CoV-2 observation pathology platform protection test purified RBD respiratory response Rhesus monkey Rhesus monkeys Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 strain SARS-CoV-2 virus significantly specific antigen Spike protein T cell the vaccine Vaccine vaccine candidate vaccine platform virus replication [DOI] 10.1021/acs.bioconjchem.1c00208 PMC 바로가기 [Article Type] Article
Structure and function analysis of a potent human neutralizing antibody CA521 FALA against SARS-CoV-2SARS-CoV-2에 대한 강력한 인간 중화 항체 CA521 FALA의 구조 및 기능 분석Article Published on 2021-04-232022-09-12 Journal: Communications Biology [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome Analysis antibody approved binding block coronavirus COVID-19 COVID-19 pandemic cryo-EM death demonstrated enzyme epitope overlapping FALA identify immunology in vitro in vivo inhibited Interaction lung mice Microbiology monoclonal antibody neutralising neutralization neutralization activity neutralize neutralizing antibody performed Protein RBD recognize reduced researchers Rhesus monkeys SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 RBD SARS-CoV-2 spike trimer SARSCoV-2 Song spike Structural analysis Structure susceptible the Spike therapeutic therapeutic intervention therapeutic target transgenic mice treating COVID-19 virus titer [DOI] 10.1038/s42003-021-02029-w PMC 바로가기 [Article Type] Article
The Gastrointestinal Tract Is an Alternative Route for SARS-CoV-2 Infection in a Nonhuman Primate Model위장관은 비인간 영장류 모델에서 SARS-CoV-2 감염에 대한 대체 경로입니다Article Published on 2021-04-012022-09-11 Journal: Gastroenterology [Category] MERS, SARS, 바이오마커, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 caspase 3 caused CD68 Chain Reaction change cleaved Clinical sign Clinical signs connection coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytokine Cytokines digestive dysfunction evaluated fecal Fecal-Oral Route Gastrointestinal GI Tract goblet cells Histopathology host responses Hypothesis immunohistochemistry increased expression increasingly Infection Inflammation Inflammatory cytokines inoculation intranasal investigated involved Ki67 lung macrophages manifestation Model mucin NHP Pathogenesis pathogenesis of COVID-19 pathogenesis of SARS-CoV-2 pathologic Patient periodic acid Pneumonia polymerase chain polymerase chain reaction primate quantified Quantitative reported respiratory respiratory tissue respiratory tissues response reverse transcription rhesus Rhesus monkeys route SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe infections staining tissue tissues tract Viral viral genomic RNA viral infection were infected were recorded [DOI] 10.1053/j.gastro.2020.12.001 PMC 바로가기 [Article Type] Article
Evaluating angiotensin-converting enzyme 2-mediated SARS-CoV-2 entry across species종에 걸친 안지오텐신 전환 효소 2 매개 SARS-CoV-2 진입 평가Article Published on 2021-01-012022-09-11 Journal: The Journal of Biological Chemistry [Category] 변종, 유전자 메커니즘, [키워드] (greater horseshoe bat) (house mouse (red junglefowl) ACE2 ACE2 protein ACE2 proteins ACE2 receptor ACE2 receptors acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Canis cells Chinese complex coronavirus Critical cross-species demonstrated entry receptor evaluated Evaluating facilitate facilitated Felis goat greater greater horseshoe bat highlighting horseshoe bat Host hosts house mouse Hypothesis Infection Interaction intermediate hosts isoform Lupus mechanism Mus Mutation natural reservoirs nonsusceptible pandemic pangolin pangolins red junglefowl reservoir residue respiratory rhesus Rhesus monkeys Rufous horseshoe bat rufous horseshoe bat) SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection severe acute respiratory syndrome Coronavirus species susceptibility Tiger snake tiger snake) Viral viral entry virus [DOI] 10.1016/j.jbc.2021.100435 PMC 바로가기 [Article Type] Article