Postvaccination anti-S IgG levels predict anti-SARS-CoV-2 neutralising activity over 24 weeks in patients with RAArticle Published on 2022-10-012022-11-15 Journal: RMD Open [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] Analysis anti-S IgG level anti-SARS-CoV-2 anti-SARS-CoV-2 vaccine antiviral activity assessment benefit comparable correlation COVID-19 declined demonstrated HCs healthy control identify IFN-γ ELISPOT IgA IgG IgG antibody IgG level IgG response IgM isotype IgM response IgM responses immune response mRNA neutralisation assay neutralisation assays neutralising Neutralising activity Patient performed potent predict Prophylactic Receptor binding domain regimen response Rheumatoid rheumatoid arthritis SARS-CoV-2 SARS-CoV-2 pseudovirus T cell response titre two-dose regimen vaccination vaccine dose Viral protein [DOI] 10.1136/rmdopen-2022-002575 PMC 바로가기
Reduced humoral response to a third dose (booster) of SARS-CoV-2 mRNA vaccines by concomitant methotrexate therapy in elderly patients with rheumatoid arthritisArticle Published on 2022-10-012022-11-15 Journal: RMD Open [Category] COVID19(2023년), SARS, 진단, [키워드] Affect binding antibody unit BNT162b2 booster booster vaccination Concomitant concomitant treatment COVID-19 disease dose Efficacy Elderly patient had no Health authority humoral humoral immune response IgG increase IQR Kruskal-Wallis test median methotrexate monotherapy mRNA vaccine mRNA vaccines mRNA-1273 Musculoskeletal Patient patients PROTECT RBD receiving Receptor binding domain reduce reduced Rheumatoid rheumatoid arthritis risk SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 vaccination second dose severe COVID-19 shown significantly the SARS-CoV-2 therapy treated vaccination was measured younger patient [DOI] 10.1136/rmdopen-2022-002632 PMC 바로가기
Impact of Perceived Stress During the SARS-CoV-2 Pandemic on Rheumatoid Arthritis Patients’ Disease Activity: An Online SurveyArticle Published on 2022-10-012022-11-15 Journal: Journal of clinical rheumatology : practical reports on rheumatic & [Category] COVID19(2023년), SARS, 진단, [키워드] age antibody assessment association black Black race category confounding factors COVID-19 COVID-19 pandemic cross-sectional demographics determine disease Disease activity disease severity Effect effort Health Impact index Linear regression model Los Angele measure mitigate moderate Multiple pandemic Patient patients Perceived Perceived Stress Scale performed Psychological Psychological stress reported responders response Rheumatoid rheumatoid arthritis rheumatology routine significant increases in Stress subject survey the patient the SARS-CoV-2 University of California variables worsened [DOI] 10.1097/RHU.0000000000001861 PMC 바로가기
Aseptic Abscess Syndrome in Rheumatoid Arthritis PatientArticle Published on 2022-09-272022-11-15 Journal: Medicina [Category] 진단, [키워드] abdominal pain abscess accompanied adalimumab Antibiotics Aseptic aseptic abscess syndrome Autoimmune diseases Bacteria characterized Clinical improvement Complete corticosteroid therapy COVID-19 infection disorder extension feature Fever IBD include Inflammatory Inflammatory bowel disease Inflammatory marker internal organ joints lack lesion lesions Leukocytosis liver Lungs microbe neutrophilic parasites Patient potentially life-threatening Practitioner Prednisone recognize reduction Remdesivir Rheumatoid rheumatoid arthritis sensitivity spleen Symptom syndrome systemic symptom tissue treated Treatment viruses weight loss [DOI] 10.3390/medicina58101354 PMC 바로가기
IFI44 is an immune evasion biomarker for SARS-CoV-2 and Staphylococcus aureus infection in patients with RAArticle Published on 2022-09-152022-11-15 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] 1,25-dihydroxy vitamin D3 activated acute respiratory syndrome analyses Analysis applied autoimmune conditions Bacteremia Bacterial Bacterial infection Bacterial infections Bioinformatics analysis Biomarker caused Cell cell membrane CIBERSORT conducted coronavirus COVID-19 Cytoscape database dataset datasets DEGs dendritic cell dendritic cells dendritic cells. differentially expressed differentially expressed gene disease DNA drug target Effectiveness examined expression FIVE functional enrichment Functional enrichment analysis GBP1 gene network GeneMANIA Genes global pandemic HERC5 humans identify Ifi44 IFI44L IFIT3 IFIT5 IFN signaling IFN signaling pathway IFN-α/β Immune cell infiltration immune cells Immune escape immune evasion immune system Immunological response Infection infections infiltration Intersection ISG15 KEGG mechanism miRNA molecular mechanism molecular target NLR OAS1 oxidative phosphorylation pathogenic bacteria pathway Patient platform positive correlation PPI network prevalent proliferation promote regulate Regulation Rheumatoid rheumatoid arthritis risk factor ROC curves RSAD2 Rtp4 SARS-CoV-2 SARS-COV-2 infection severe coronavirus disease signaling pathway Staphylococcus Staphylococcus aureus target the SARS-CoV-2 therapeutic viral infection viral replication virus were used YY1 [DOI] 10.3389/fimmu.2022.1013322 PMC 바로가기
Rheumatoid arthritis patients treated with Janus kinase inhibitors show reduced humoral immune responses following BNT162b2 vaccinationJanus kinase inhibitor로 치료받은 류마티스 관절염 환자, BNT162b2 백신 접종 후 체액성 면역 반응 감소Article Published on 2022-08-032022-09-12 Journal: Rheumatology (Oxford, England) [Category] SARS, 진단, [키워드] Activation alteration analysed anti-spike antibodies anti-Spike IgG Anti-spike IgG antibody antibodies antibody antibody titres Arthritis B cell B cell responses B cells B-lymphocytes BNT162b2 BNT162b2 vaccine collected COVID-19 COVID-19 vaccine determine dose Efficacy elicited ELISA expression germinal centre healthy individual healthy individuals humoral humoral immune response Humoral immunity IgA antibody individuals JAK inhibitor Janus kinase Janus kinase inhibitor Janus kinase inhibitors less mRNA-based COVID-19 vaccine neutralization activity Neutralization assay neutralization capacity Patient patients patients treated plasma plasma sample quantitative PCR reduced Rheumatoid rheumatoid arthritis SARS-CoV-2 SARS-COV-2 infection shown Spike protein suppressed the SARS-CoV-2 the vaccine titre treated vaccination Vaccine Vaccines Virus neutralization was reduced was used [DOI] 10.1093/rheumatology/keab879 PMC 바로가기 [Article Type] Article
Role of booster with BNT162b2 mRNA in SARS-CoV-2 vaccination in patients with rheumatoid arthritis류마티스 관절염 환자에서 SARS-CoV-2 백신 접종에서 BNT162b2 mRNA를 포함한 부스터의 역할Article Published on 2022-08-012022-09-12 Journal: Immunologic research [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] addition age Analysis analyzed anti-IL6 antibody BAU BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine booster booster vaccination Booster vaccine Case report csDMARDs Disease activity Effect evaluated evidenced first vaccination Flow cytometry analysis HCW HCWs Health care worker IgG IgG level indicated jak inhibitors Level lymphocyte subpopulation mRNA BNT162b2 Necrosis Patient patients positive predictor RBD IgG Regression Rheumatoid rheumatoid arthritis role RTX SARS CoV-2 SARS-CoV-2 vaccination Seroconversion serum antibody spike therapy TNF treated Treatment vaccination Vaccination SARS-CoV-2 was determined [DOI] 10.1007/s12026-022-09283-y PMC 바로가기 [Article Type] Article
Absent or suboptimal response to booster dose of COVID-19 vaccine in patients with autoimmune systemic diseases자가 면역 전신 질환 환자에서 COVID-19 백신의 추가 용량에 대한 부재 또는 차선책 반응Observational Study Published on 2022-07-012022-09-12 Journal: Journal of autoimmunity [Category] MERS, 임상, 진단, [키워드] administration antibody ASD Autoimmune Autoimmune systemic diseases BNT162b2 booster dose Booster vaccine Control controls COVID-19 COVID-19 vaccine COVID-19 vaccines Cryoglobulinemic vasculitis dose effective elicited evaluated exhibiting first vaccination Follow-up identify increased risk individual Infection mRNA COVID-19 vaccine mRNA-1273 multicenter Neutralizing antibodies Patient patients persistence Rheumatoid rheumatoid arthritis Seroconversion serum significantly significantly higher significantly increased systemic systemic disease Systemic lupus Systemic sclerosis systemic vasculitis the mean therapeutic strategy Treatment vaccination Vaccine [DOI] 10.1016/j.jaut.2022.102866 PMC 바로가기 [Article Type] Observational Study
Successful Treatment of SARS-CoV-2 Vaccination-related Activation of Rheumatoid Arthritis with Positive Findings for Epstein-Barr VirusEpstein-Barr 바이러스에 대한 양성 결과로 류마티스 관절염의 SARS-CoV-2 백신 접종 관련 활성화의 성공적인 치료Case Reports Published on 2022-07-012022-09-12 Journal: Internal medicine (Tokyo, Japan) [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome administration Antigen clinical disease coronavirus COVID-19 Disease activity EBV Epstein-Barr virus Fever finding IgG introduced joint polyarthritis Protein Rheumatoid rheumatoid arthritis SARS-CoV-2 SARS-CoV-2 vaccination Tocilizumab treat Vaccine virus [DOI] 10.2169/internalmedicine.9433-22 PMC 바로가기 [Article Type] Case Reports
Frequency and severity of COVID-19 in patients with various rheumatic diseases treated regularly with colchicine or hydroxychloroquine콜히친 또는 하이드록시클로로퀸으로 정기적으로 치료받는 다양한 류마티스 질환 환자의 COVID-19 빈도 및 중증도Article Published on 2022-07-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 진단, 치료법, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus analyzed anti-SARS-CoV-2 IgG Arthritis being Clinical data Colchicine collected Contact control group coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19-related symptom COVID-19-related symptoms described disease Famial Mediterranean fever Familial Familial Mediterranean fever FIVE HCQ healthy hospital Hospital admission Hospitalized household contact Hydroxychloroquine IgG Immunoglobulin Immunoglobulin G less Lupus lupus erythematosus Manifestations Mediterranean fever Musculoskeletal nucleocapsid occurred Odds ratio Patient positive prevention of COVID-19 respiratory rheumatic and musculoskeletal disease. rheumatic disease Rheumatoid rheumatoid arthritis seropositive subjects serum sample serum samples severe disease severity of COVID-19 subject syndrome systemic systemic lupus erythematosus the patient treated Treatment [DOI] 10.1002/jmv.27731 PMC 바로가기 [Article Type] Article