Efficacy of Ion-Channel Inhibitors Amantadine, Memantine and Rimantadine for the Treatment of SARS-CoV-2 In Vitro시험 관내 SARS-COV-2의 치료를위한 이온 채널 억제제 아만타딘, 메만 틴 및 리만타딘의 효능Brief Report Published on 2021-10-152022-09-10 Journal: Viruses [Category] SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adamantane amantadine antagonistic Antiviral barrier to escape cells combination treatment coronavirus COVID-19 Drug repurposing effective Efficacy followed by hepatitis C virus p7 inhibitor hepatoma highest Huh7.5 in vitro inhibitor inhibitors ion-channel inhibitor lung carcinoma Memantine Remdesivir respiratory Rimantadine SARS-CoV-2 selectivity index severe acute respiratory syndrome Coronavirus Treatment VeroE6 cells Viral viral entry viral escape [DOI] 10.3390/v13102082 PMC 바로가기 [Article Type] Brief Report
Predicted antiviral drugs Darunavir, Amprenavir, Rimantadine and Saquinavir can potentially bind to neutralize SARS-CoV-2 conserved proteinsResearch Published on 2021-08-042022-10-30 Journal: Journal of Biological Research [Category] COVID-19, [키워드] Abstract active site Amprenavir analyzed anti-viral drug antiviral drug antiviral drugs binding conserved Coronavirus disease 2019 COVID-19 COVID-19 patient darunavir drug drug target drugs enzyme Enzymes Helicase Host humans include life cycle methyltransferase Mortality motif neutralize non-structural proteins novel Papain-like protease pathogenicity predicted Prevent protease Protein Proteins replicase repurposing Result Rimantadine RNA-dependent RNA polymerase saquinavir SARS-CoV-2 supplementary material target the SARS-CoV-2 treat Trial [DOI] 10.1186/s40709-021-00149-2 PMC 바로가기 [Article Type] Research
All-cause mortality among patients treated with repurposed antivirals and antibiotics for COVID-19 in Mexico City: A real-world observational studyOriginal Article Published on 2021-02-042022-10-31 Journal: EXCLI Journal [Category] COVID-19, [키워드] acyclovir age all-cause mortality amantadine Antibiotics Antiviral antivirals benefit COVID-19 Critical death eliminated estimating equations evaluate General population group Hospitalized increased mortality increased risk laboratory-confirmed limit men Mexico City modify Mortality mortality risk multivariable n=36 occurred oseltamivir Patient patients patients evaluated patients treated performed pharmacoepidemiology positive RT-PCR Pregnancy propensity score matching protective factor receiving retrospective cohort study Rimantadine risk risk factor SARS-CoV-2 sub-cohort survival treated zanamivir [DOI] 10.17179/excli2021-3413 PMC 바로가기 [Article Type] Original Article
Antiviral drugs for influenza for 2020-2021Article Published on 2020-11-022023-07-12 Journal: The Medical letter on drugs and therapeutics [Category] SARS, [키워드] adverse effects amantadine antiviral drugs baloxavir coronavirus dosage Drug interactions Efficacy FluMist Influenza influenza vaccine lactation neuraminidase inhibitors oseltamivir Peramivir Pregnancy Rapivab Relenza Rimantadine Safety Tamiflu Xofluza zanamivir