SARS-CoV-2 Nsp1 mediated mRNA degradation requires mRNA interaction with the ribosomearticle Published on 2023-07-062024-09-05 Journal: RNA Biology [Category] update2024, [키워드] Host shutoff nsp1 RNA decay SARS-CoV-2 stress granule translation [DOI] 10.1080/15476286.2023.2231280 PMC 바로가기 [Article Type] article
Differential regulation of mRNA stability modulates transcriptional memory and facilitates environmental adaptationarticle Published on 2023-02-172024-09-05 Journal: Nature Communications [Category] update2024, [키워드] epigenetics RNA decay transcriptomics [DOI] 10.1038/s41467-023-36586-x PMC 바로가기 [Article Type] article
Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamicsArticle Published on 2021-01-272022-10-04 Journal: Nature Communications [Category] 변종, [키워드] Analysis biochemical Biochemistry catalytic cleavage conformational conserved coronavirus Coronaviruses Critical cryo-EM cryo-EM structure Cryoelectron microscopy crystal structure dataset Defense determine enzyme evade experiments facilitate Host mass spectrometry mechanism molecular Molecular dynamics simulation phosphate phosphodiester bond recognize regulate residue RNA RNA decay SARS-CoV-2 shown specificity structural framework Structure the SARS-CoV-2 uridine viral infection Viral RNA [DOI] 10.1038/s41467-020-20608-z PMC 바로가기 [Article Type] Article