HPAI-resistant Ri chickens exhibit elevated antiviral immune-related gene expressionArticle Published on 2023-01-012023-06-22 Journal: Journal of veterinary science [Category] 조류인플루엔자, [키워드] GSEA influenza A virus Ri chicken RNA-Seq Signaling pathway. [DOI] 10.4142/jvs.22229 PMC 바로가기
Analysis of Expression Pattern of snoRNAs in Human Cells A549 Infected by Influenza A VirusArticle Published on 2022-11-082023-06-23 Journal: International Journal of Molecular Sciences [Category] 신종인플루엔자, [키워드] A549 H1N1 human cells influenza A virus ncRNAs RNA-Seq sdRNAs snoRNAs Transcriptome. [DOI] 10.3390/ijms232213666 PMC 바로가기
Host gene expression is associated with viral shedding magnitude in blue-winged teals (Spatula discors) infected with low-path avian influenza virusArticle Published on 2022-11-012023-06-22 Journal: Comparative Immunology, Microbiology and Infectious Diseases [Category] 조류인플루엔자, [키워드] Avian Influenza blue-winged teal Gene Expression RNA-Seq Supershedders Viral shedding. [DOI] 10.1016/j.cimid.2022.101909 PMC 바로가기
Comparative Upper Respiratory Tract Transcriptomic Profiling Reveals a Potential Role of Early Activation of Interferon Pathway in Severe COVID-19Article Published on 2022-10-012022-11-15 Journal: Viruses [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] Acute respiratory infection Comparative Coronavirus disease 2019 COVID-19 COVID-19 negative COVID-19 patient COVID-19 patients death driving evaluated Genes Host transcriptional response host-pathogen interactions IFN-I IFN-I response Inflammation initial symptom interferon involved ISG ISGs lung mechanism Mild OAS Potential Profiling progression respiratory Respiratory failure RNA-Seq RNA-sequencing role SARS-CoV-2 severe COVID-19 patient severe COVID-19 patients severe symptom stimulated symptomatic patient the disease tract type I interferon upper upper respiratory tract upregulated viral infection Viral infection. Viral load [DOI] 10.3390/v14102182 PMC 바로가기
Blood gene expression predicts intensive care unit admission in hospitalised patients with COVID-19Article Published on 2022-09-202022-11-16 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, [키워드] activated Admission Alpha Biomarkers Blood Cohort COVID-19 COVID-19 pandemic Critical care defined EGFR epidermal expression First wave Gene Expression gene expression signature gene signature growth factor healthcare Healthcare system hospital hospitalised hospitalised patient ICU admission individual information intensive care intensive care unit naïve outcomes pathway Patient patients with COVID-19 peroxisome predict predicted Predictive Prognosis prognostic receptor resource RNA RNA sequencing RNA-Seq RNA-seq - RNA sequencing ROC tested TGF-β topological data analysis Topology Transcriptome Transcriptome. transforming growth factor Treatment was measured Whole blood with COVID-19 [DOI] 10.3389/fimmu.2022.988685 PMC 바로가기
SARS-CoV-2 can infect human embryosArticle Published on 2022-09-142022-11-15 Journal: Scientific Reports [Category] SARS, 치료기술, 치료제, [키워드] ACE2 antibody canonical Cell cell entry cells co-expressed COVID-19 COVID-19 pandemic Effect Embryo embryogenesis embryos Factor fluorescent glycoprotein Health human tissue identify immunofluorescence implicated implication infect Infection observé organ pandemic Pregnancy reporter reproductive resulting RNA-Seq robust SARS-CoV-2 SARS-COV-2 infection spike Spread susceptibility susceptible Symptom target tissue TMPRSS2 viral entry virions pseudotyped [DOI] 10.1038/s41598-022-18906-1 PMC 바로가기
The Th1/Tfh-like biased responses elicited by the rASP-1 innate adjuvant are dependent on TRIF and Type I IFN receptor pathwaysArticle Published on 2022-09-022023-06-14 Journal: Frontiers in Immunology [Category] Fulltext, 신종인플루엔자, [키워드] conventional DCs influenza vaccine innate adjuvant rASP-1. RNA-Seq TLR4 TRIF type I interferon receptor [DOI] 10.3389/fimmu.2022.961094 PMC 바로가기
Cellular heterogeneity in disease severity and clinical outcome: Granular understanding of immune response is keyArticle Published on 2022-08-222022-11-16 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, [키워드] age cellular cellular heterogeneity Clinical outcome clinical outcomes Comorbidities complex correlation COVID-19 COVID-19 disease COVID-19 disease severity disease severity dysregulation functional Gender genetics granular heterogeneity heterogeneous heterogeneous population highlight Host host response identify immune immune cells Immune profile immune response immunological mechanism impairment Infectious disease information pandemic Patient progression regulated RNA-Seq severity single-cell genomics single-cell genomics. subset the disease with COVID-19 [DOI] 10.3389/fimmu.2022.973070 PMC 바로가기
Differential gene expression profiling reveals potential biomarkers and pharmacological compounds against SARS-CoV-2: Insights from machine learning and bioinformatics approachesArticle Published on 2022-08-172022-11-15 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 치료기술, 치료제, [키워드] acid approach bioinformatics caused Comorbidities complex interplay Compound contribute coronavirus 2 COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 progression Critical cyclosporine DEGs detect develop differentially expressed gene disease disease pathogenesis dysregulated E2F1 effort EGR1 expressed Factor functional functional enrichment Gene expression profiling Gene regulatory networks Genetic Genomics healthy controls healthy individual humans identify indicated individual individuals insight inter-individual Interaction machine learning approach MAX Mental mental retardation miRNA expression miRNAs nasopharyngeal network analysis offer Ontology overexpressed pandemic pathophysiology pathway pharmacological Potential biomarker Regulatory respiratory responsible reveal RNA-Seq RNA-seq data SARS-CoV-2 SARS-COV-2 infection Spread SRF TFS the SARS-CoV-2 therapeutic option therapeutic target therapeutic targets therapeutic targets. Vaccine Variability with COVID-19 YY1 [DOI] 10.3389/fimmu.2022.918692 PMC 바로가기
Host and microbiome features of secondary infections in lethal covid-19Research article Published on 2022-08-132022-10-05 Journal: iScience [Category] 바이오마커, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] alteration Bacterial C1q cause cellular complement contribute Control DAD death Defense Diffuse alveolar damage dominant driving Factor feature fungal pathogen highlight Immunity immunology inhibitory lethal lung lung tissue Macrophage microbial Microbiome Mortality myeloid cells organ pandemic pathology pathophysiological reduced RNA-Seq SARS-COV-2 infection Secondary infection secondary infections significantly stratified subgroup Virology [DOI] 10.1016/j.isci.2022.104926 [Article Type] Research article