Spatial distribution of Mycobacterium tuberculosis mRNA and secreted antigens in acid-fast negative human antemortem and resected tissueArticle Published on 2024-06-152024-09-05 Journal: eBioMedicine [Category] update2024, [키워드] Antigen Diagnosis RNAscope Tuberculosis Ziehl-Neelsen [DOI] 10.1016/j.ebiom.2024.105196 PMC 바로가기 [Article Type] Article
Pigs lacking TMPRSS2 displayed fewer lung lesions and reduced inflammatory response when infected with influenza A virusGenome Editing Original Research Published on 2024-05-312024-09-05 Journal: Frontiers in Genome Editing [Category] update2024, [키워드] influenza A knockout Proinflammatory response RNAscope somatic cell nuclear transfer swine TMPRSS2 gene [DOI] 10.3389/fgeed.2023.1320180 PMC 바로가기 [Article Type] Genome Editing Original Research
Validation of an RNAscope assay for the detection of avian influenza A virusFull Scientific Reports Published on 2023-06-192024-09-05 Journal: Journal of veterinary diagnostic investigation : o [Category] update2024, [키워드] avian influenza A virus immunohistochemistry RNAscope tissue microarray [DOI] 10.1177/10406387231182385 PMC 바로가기 [Article Type] Full Scientific Reports
Visualising SARS-CoV-2 infection of the lung in deceased COVID-19 patientsArticle Published on 2023-05-222024-09-05 Journal: eBioMedicine [Category] update2024, [키워드] nucleocapsid RNAscope single-stranded RNA virus spike [DOI] 10.1016/j.ebiom.2023.104608 PMC 바로가기 [Article Type] Article
Simultaneous detection and quantification of spike mRNA and protein in SARS-CoV-2 infected airway epithelium .Method Article Published on 2023-02-032024-09-05 Journal: MethodsX [Category] update2024, [키워드] IHC RNAscope S mRNA S protein SARS-CoV-2 [DOI] 10.1016/j.mex.2023.102050 PMC 바로가기 [Article Type] Method Article
Anatomical barriers against SARS-CoV-2 neuroinvasion at vulnerable interfaces visualized in deceased COVID-19 patientsArticle Published on 2022-12-072023-07-10 Journal: Neuron [Category] COVID19(2023년), [키워드] blood-brain barrier brain parenchyma coronavirus COVID-19 Delta frontal lobe glia limitans perivascularis leptomeninges neuroinvasion neurotropism olfactory olfactory bulb olfactory sensory neuron omicron perineurial olfactory nerve fibroblast. RNAscope SARS-CoV-2 Virchow-Robin space [DOI] 10.1016/j.neuron.2022.11.007 PMC 바로가기
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in a Dog in Connecticut in February 20212021 년 2 월 코네티컷의 개에있는 심한 급성 호흡기 증후군 코로나 바이러스 2 (SARS-COV-2)Brief Report Published on 2021-10-232022-09-10 Journal: Viruses [Category] MERS, SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 conducted Connecticut coronavirus coronavirus 2 COVID-19 D614G diagnostic died dog dominant ENhance Epidemiology Genetic Genome sequencing HCoV Human identify In situ hybridization Laboratory Lineage multiple organ multiple organs Mutation negative Nsp12 P323L Phylogenetic analysis positive postmortem examination public health real time-PCR respiratory reverse transcription RNA RNAscope RT-qPCR SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus submitted substitutions sudden death The United States United States Viral Viral RNA virus Winter zoonotic [DOI] 10.3390/v13112141 PMC 바로가기 [Article Type] Brief Report
Postmortem Cardiopulmonary Pathology in Patients with COVID-19 Infection: Single-Center Report of 12 Autopsies from Lausanne, SwitzerlandArticle Published on 2021-07-282022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] acute fibrinous acute respiratory syndrome Autopsy bronchitis bronchopneumonia coronavirus COVID-19 DAD died Diffuse alveolar damage immunohistochemistry mechanical ventilation median men necrotic onset of symptom onset of symptoms Organizing pneumonia Patient patients patients with COVID-19 post-mortem diagnostics Postmortem Prevalence quantitative PCR report reverse transcriptase reverse transcriptase quantitative PCR RNA RNAscope SARS-CoV-2 supported Switzerland symptomatic the patient tissue virus virus detection with COVID-19 women [DOI] 10.3390/diagnostics11081357 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Causes Acute Kidney Injury by Directly Infecting Renal TubulesCell and Developmental Biology Published on 2021-05-312022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome addition AKI Angiotensin-converting enzyme Autopsy Blood urea nitrogen cause causes cell type cells cohort analysis Complication coronavirus coronavirus disease Course COVID-19 COVID-19 patients demonstrated disease stage distal expressed Hospitalized human kidney kidney Kidney injury marker occurred outcome patients patients with COVID-19 poor prognosis positive prevalent protease protein level proximal tubular cells renal renal tubular cells Risk factors RNAscope SARS-CoV-2 SARS-COV-2 infection serine 2 significantly significantly higher spike the SARS-CoV-2 TMPRSS2 transmembrane tubular cell Tubule [DOI] 10.3389/fcell.2021.664868 PMC 바로가기 [Article Type] Cell and Developmental Biology