Transitioning from Intravenous to Subcutaneous Vedolizumab in Patients with Inflammatory Bowel Disease [TRAVELESS]염증성 장 질환 환자에서 정맥 주사에서 피하 베돌리주맙으로 전환 [TRAVELESS]Article Published on 2022-07-142022-09-12 Journal: Journal of Crohn's & colitis [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Adverse drug reactions appear baseline benefit biochemical bowel calprotectin clinically Cohort cohort of patients declining Disease activity dose effective evaluate expected Health Service IBD increase in Inflammatory bowel disease injection intravenous measure offered outcome Patient Patient satisfaction reaction reason reduction reported risk factor routine clinical care Safe SARS-COV-2 infection statistically significant statistically significant difference Subcutaneous switching TRAVELESS Treatment unlikely vedolizumab Week [DOI] 10.1093/ecco-jcc/jjab224 PMC 바로가기 [Article Type] Article
Establishing COVID-19 trials at scale and pace: Experience from the RECOVERY trialResearch article Published on 2022-07-012022-10-05 Journal: Advances in biological regulation [Category] COVID19(2023년), SARS, 임상, 치료제, [키워드] Baricitinib benefit benefits of treatment common diseases COVID-19 COVID-19 therapy Dexamethasone drug enrolled Establishing evaluate experience hospitalised identify moderate numbers of patient pandemic Patient Randomised Evaluation recovery RECOVERY trial recruitment routine clinical care shown the SARS-CoV-2 Tocilizumab Treatment Trial with COVID-19 [DOI] 10.1016/j.jbior.2022.100901 [Article Type] Research article
Immunologic response of mRNA SARS-CoV-2 vaccination in adolescent kidney transplant recipients청소년 신장 이식 환자에서 mRNA SARS-CoV-2 백신 접종의 면역학적 반응Article Published on 2022-02-012022-09-12 Journal: Pediatric Nephrology (Berlin, Germany) [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Adolescent age anti-S antibody antibody Antibody Response Cellular immune response Corticosteroid COVID-19 COVID-19 infection described dose ENhance evaluated Future General population Immunologic Immunosuppressed Immunosuppression inhibitor IQR kidney transplant kidney transplant recipient lower dose mRNA mRNA vaccine non-responders participant Patient patients pediatric positive positive antibody response Protein regimen reported routine clinical care Safe SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 vaccination SARS-CoV-2 vaccine second dose solid organ transplant SOT SOT patient SOT patients Support the median the vaccine treated vaccination vaccine immunogenicity vaccine response Viremia [DOI] 10.1007/s00467-021-05256-9 PMC 바로가기 [Article Type] Article
Setting-Up a Rapid SARS-CoV-2 Genome Assessment by Next-Generation Sequencing in an Academic Hospital Center (LPCE, Louis Pasteur Hospital, Nice, France)Medicine Published on 2022-01-112022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Analysis approach Aside assessment automated B.1.1.7 center collected Complete correlation COVID-19 detect Diagnosis Efficiency European feasibility France Genexus Genome sequencing highlight hospital Ion Laboratory limitation Louis Pasteur material Nasopharyngeal swab Next-generation sequencing next-generation sequencing (NGS) Rapid repeated reverse transcription-PCR RNA extraction routine clinical care Saliva SARS-CoV-2 SARS-CoV-2 positive individuals SARS-CoV-2 variant Sequencing single hospital the SARS-CoV-2 the SARS-CoV-2 genome These data variant variants variants of SARS-CoV-2 Viral genome sequencing Viral load was performed [DOI] 10.3389/fmed.2021.730577 PMC 바로가기 [Article Type] Medicine
SARS-CoV-2 Vaccine Effectiveness in a High-Risk National Population in a Real-World Setting실제 환경에서 고위험 인구의 SARS-CoV-2 백신 효과Article Published on 2021-10-012022-09-11 Journal: Annals of internal medicine [Category] SARS, 변종, [키워드] 95% CI Affair age BNT-162b2 body mass body mass index Care case-control study Comorbidities Department determine disease severity effective Effectiveness Emergency use authorization evaluate Follow-up Health Health care Health care system high-risk population Infection lack Logistic regression male median age Moderna Moderna mRNA-1273 vaccine Mortality mRNA-1273 Participants Pfizer Pfizer-BioNTech Population positive presence of comorbidities Propensity score remained routine clinical care SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination SARS-CoV-2 variant SARS-CoV-2 variants second dose setting Sex tested the median vaccination Vaccine veteran white [DOI] 10.7326/M21-1577 PMC 바로가기 [Article Type] Article
Rationale and Design of the Awake Prone Position for Early Hypoxemia in COVID-19 Study Protocol: A Clinical TrialCOVID-19 연구 프로토콜에서 초기 저산소혈증에 대한 깨어 있기 쉬운 자세의 근거 및 설계: 임상 시험Article Published on 2021-09-012022-09-11 Journal: Annals of the American Thoracic Society [Category] SARS, 임상, [키워드] adaptive Awake prone positioning Bayesian Bayesian analysis clinical clinical outcomes clinical trial collected conservation Controlled clinical trial coronavirus disease COVID-19 disease effective effective intervention Effectiveness Enrollment facilitate Hypoxemia improve clinical outcomes include International Intervention limit measure medical record multicenter outcome patients with COVID-19 Personal protective equipment position Pragmatic prone Prone position public health randomization Randomized rationale Registered routine clinical care social distancing Support Treatment Trial urgency virulence [DOI] 10.1513/AnnalsATS.202009-1124SD PMC 바로가기 [Article Type] Article
The state of telemedicine for persons with Parkinson’s diseaseMOVEMENT DISORDERS: Edited by Per Svenningsson Published on 2021-08-272022-11-01 Journal: Current Opinion in Neurology [Category] Coronavirus, MERS, SARS, [키워드] administer barrier benefit Brain Care clinical outcomes Clinical practice clinician Cognitive behavioural therapy consultation Contact Diagnosis disease Effectiveness exploratory facilitated finding Future highlight implementation IMPROVE include Intervention lack monitoring neurological Neurological disorders outcome parameters Parkinson's Disease Patient patients Randomized controlled trial recent Research routine clinical care Support Telemedicine Treatment Trial [DOI] 10.1097/WCO.0000000000000953 PMC 바로가기 [Article Type] MOVEMENT DISORDERS: Edited by Per Svenningsson
The UPMC OPTIMISE-C19 (OPtimizing Treatment and Impact of Monoclonal antIbodieS through Evaluation for COVID-19) trial: a structured summary of a study protocol for an open-label, pragmatic, comparative effectiveness platform trial with response-adaptive randomizationUPMC OPTIMISE-C19(COVID-19에 대한 평가를 통한 단일 클론 항체의 치료 및 영향 최적화) 시험: 반응 적응형 무작위 배정이 포함된 개방형, 실용적, 비교 효과 플랫폼 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-05-252022-09-01 Journal: Trials [Category] SARS, 변종, 임상, 진단, [키워드] adaptive Administered administration aggregate authorization bamlanivimab Bayesian blinded Blinding calculated captures Casirivimab collected Comorbidities comparator composite endpoint Course COVID-19 criteria dependent on determine determined by dissemination distribution Dosing drug Effectiveness effort element eligibility criteria Emergency emergency department Emergency Departments etesevimab EUA evaluate evaluated FDA Final Follow-up food futility Government high risk hospital Hospitalization Hospitalized Identifier Imdevimab Impact include increase in inferiority infusion Intervention investigator investigators mAbs manuscript medical record Mild mild to moderate Mild to moderate COVID-19 Moderate COVID-19 monoclonal antibodies monoclonal antibody monotherapy number obese objective Open-label outcome outcome assessor outcome assessors oxygen pandemic participant Patient physician Platform trial Pragmatic pragmatic trial Primary outcome protocol provide random random allocation randomised randomised controlled trial randomization reached receive recorded recruitment routine clinical care Sample Sample size SARS-CoV-2 variant SARS-CoV-2 variants severe COVID-19 statistical statistical inference status Study protocol submission supplementary material supply sustained Symptoms System the patient the United State therapeutic Treatment treatment of COVID-19 Trial Trial registration United States US Food and Drug Administration Version Volume website [DOI] 10.1186/s13063-021-05316-3 PMC 바로가기 [Article Type] Letter
Clinical characterization of respiratory large droplet production during common airway procedures using high-speed imaging고속 영상을 사용하여 일반적인 기도 절차 중 호흡기의 큰 비말 생성에 대한 임상 특성화Article Published on 2021-05-202022-08-31 Journal: Scientific Reports [Category] 치료제, [키워드] aerosol Aerosols airway airway management Characteristics clinical coughing COVID-19 pandemic Disease prevention dissemination distance droplet droplets healthcare healthcare worker Healthcare workers infected with SARS-CoV-2 investigated knowledge life Mechanical engineering non-invasive ventilation Particle random reduced respiratory risk routine clinical care speaking therapy tracheal cannula trajectory Type velocity video camera [DOI] 10.1038/s41598-021-89760-w PMC 바로가기 [Article Type] Article
Diagnosis and Management of Osteoporosis During COVID-19: Systematic Review and Practical GuidanceReview Article Published on 2021-05-182022-10-31 Journal: Calcified Tissue International [Category] COVID-19, MERS, SARS, [키워드] affected Care caused COVID-19 COVID-19 pandemic Deterioration Diagnosis DXA FIVE FRAX healthcare service impacted information limitation Long-term condition management Osteoporosis Osteoporosis management pandemic pathway Patient platform provide public health recommendation reduce required resource review risk risk stratification routine clinical care skeletal supplementary material therapy treated Treatment [DOI] 10.1007/s00223-021-00858-9 PMC 바로가기 [Article Type] Review Article