Rutin from Begonia roxburghii modulates iNOS and Sep A activity in treatment of Shigella flexneri induced diarrhoea in rats: An in vitro, in vivo and computational analysisarticle Published on 2023-11-302024-09-01 Journal: Microbial Pathogenesis [Category] 세균성이질, [키워드] Begonia roxburghii Diarrhoea score Na(+)/K(+)–ATPase rutin Sep A Shigella flexneri [Article Type] article
Dual inhibition of SARS-CoV-2 spike and main protease through a repurposed drug, rutinArticle Published on 2022-07-012023-07-06 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, [키워드] Drug repurposing main protease MD simulation rutin SARS-CoV-2 Spike protein [DOI] 10.1080/07391102.2020.1864476 PMC 바로가기
Promising Therapeutic Approach for SARS-CoV-2 Infections by Using a Rutin-Based Combination Therapy루틴 기반 조합 요법을 사용하여 SARS-CoV-2 감염에 대한 유망한 치료 접근 방식Article Published on 2022-06-032022-09-11 Journal: ChemMedChem [Category] COVID19(2023년), SARS, 치료제, [키워드] Acetylsalicylic acid addition Administered antioxidants Antiviral Antiviral agents Bacterial calcium combating combination therapy components compounds described early stage early stages flavonoids host cell indication Infection inhibit Magnesium molecular molecular recognition natural natural products noncovalent interactions offer prophylactically provide rutin Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections severe disease progression targets Therapeutic approach therapy viruses Vitamin C Vitamin D vitamins [DOI] 10.1002/cmdc.202200157 PMC 바로가기 [Article Type] Article
Flavonols and dihydroflavonols inhibit the main protease activity of SARS-CoV-2 and the replication of human coronavirus 229EArticle Published on 2022-04-122023-06-15 Journal: Virology [Category] COVID19(2023년), MERS, SARS, [키워드] (+)-dihydrokaempferol (+)-dihydromyricetin (+)-dihydroquercetin (taxifolin) flavan-3-ols Isoquercitrin kaempferol Myricentin quercetin rutin [DOI] 10.1016/j.virol.2022.04.005 PMC 바로가기 [Article Type] Article
Rutin ameliorates malaria pathogenesis by modulating inflammatory mechanism: an in vitro and in vivo studyarticle Published on 2022-02-282024-09-01 Journal: InflammoPharmacology [Category] 말라리아, [키워드] Anti-inflammatory anti-oxidative malaria mice Plasmodium rutin [Article Type] article
Exploration of the Mechanism of Lianhua Qingwen in Treating Influenza Virus Pneumonia and New Coronavirus Pneumonia with the Concept of “Different Diseases with the Same Treatment” Based on Network PharmacologyResearch Article Published on 2022-02-082022-10-31 Journal: Evidence-based Complementary and Alternative Medicine : eCAM [Category] COVID-19, [키워드] 3CL ACE2 angiotensin-converting enzyme 2 Apoptosis binding biological process biological processes cell proliferation component components concept COX2 cytokine Cytoscape database DAVID docking docking result emodin enrichment analysis exploration FIVE IL-17 IL-6 immune system Influenza virus interleukin-6 Intervention Invasion involved KEGG Kyoto Luteolin MAPK mechanism metabolism Necrosis network New Novel coronavirus Occurrence Ontology pathway Pathway enrichment analysis Pathways Pharmacology Pneumonia protease Protein quercetin Regulation Result rutin screened Seven T cell receptor target targets TNF Toll-like receptor treating Treatment was used [DOI] 10.1155/2022/5536266 PMC 바로가기 [Article Type] Research Article
Can Artemisia herba-alba Be Useful for Managing COVID-19 and Comorbidities?Artemisia Herba-Alba가 Covid-19 및 동반 질환을 관리하는 데 유용 할 수 있습니까?Article Published on 2022-01-132022-08-31 Journal: Molecules [Category] 치료제, [키워드] Artemisia herba-alba activity alba associated symptoms binding Can Combination Comorbidities Comorbidity component COVID-19 disease Efficacy evaluate example exploratory study focus identify in silico managing medicinal plants molecular molecular docking molecular dynamics pharmacological plant plants reported Research rutin SARS-CoV-2 selected silico studies Symptom Therapeutic treatment therapeutic use Treatment [DOI] 10.3390/molecules27020492 PMC 바로가기 [Article Type] Article
Rescuing the Host Immune System by Targeting the Immune Evasion Complex ORF8-IRF3 in SARS-CoV-2 Infection with Natural Products Using Molecular Modeling Approaches분자 모델링 접근 방식을 사용하여 천연물을 사용한 SARS-CoV-2 감염의 면역 회피 복합체 ORF8-IRF3을 표적으로 하여 숙주 면역 시스템 구출Article Published on 2021-12-232022-09-10 Journal: International Journal of Environmental Research an [Category] SARS, 변종, 진단, [키워드] African Analysis approaches best Bioactivity complex Compound compounds computational method Computational methods COVID-19 infection database determine disease severity Dissociation constant docking drug drugs ENCODE Endoplasmic reticulum followed by help host immune system hydrogen hydrogen bonds immune evasion immune response in silico in vitro in vivo induce inhibitor IRF3 modeling molecular molecular dynamics molecular dynamics simulations natural ORF8 pandemic performed product Protein protocol quercetin reported respiratory rutin SARS-CoV-2 South Stress System targeting Therapeutics these compound these compounds Tribuloside unique upper respiratory variant Virtual screening virus [DOI] 10.3390/ijerph19010112 PMC 바로가기 [Article Type] Article
l -Arginine Improves Solubility and ANTI SARS-CoV-2 Mpro Activity of Rutin but Not the Antiviral Activity in Cellsl-아르기닌은 루틴의 용해도 및 ANTI SARS-CoV-2 Mpro 활성을 개선하지만 세포의 항바이러스 활성은 개선하지 않습니다Article Published on 2021-10-072022-09-10 Journal: Molecules [Category] SARS, 신약개발, 치료제, [키워드] l-arginine activity anti-SARS-CoV-2 arginine cellular COVID-19 pandemic drug in silico inhibitor main protease mixture outbreak pharmaceutical preparations pharmacokinetic pharmacological quercetin rutin SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 Mpro solubility starting point Test water [DOI] 10.3390/molecules26196062 PMC 바로가기 [Article Type] Article
Pimenta dioica (L.) Merr. Bioactive Constituents Exert Anti-SARS-CoV-2 and Anti-Inflammatory Activities: Molecular Docking and Dynamics, In Vitro, and In Vivo Studies피 멘타 디오카 (L.) 메르.생물 활성 성분은 항 -SARS-COV-2 및 항 염증 활성을 발휘합니다 : 분자 도킹 및 역학, 시험 관내 및 생체 내 연구Article Published on 2021-09-272022-08-31 Journal: Molecules [Category] SARS, 유전자 메커니즘, 치료제, [키워드] Pimenta Acetate acute respiratory distress anti-inflammatory agent anti-inflammatory agents anti-inflammatory effect Anti-inflammatory effects anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity Anti-viral chloride chlorogenic acid Clinical studies clinical study Combination Compound compounds Constituent coronavirus disease coronavirus disease 19 COVID-19 COVID-19 patients Critical cytokine cytotoxicity docking and dynamics simulations Dynamics Effect ethyl acetate Evidence expression ferulic acid G-CSF gallic acid Genetic IL-10 IL-1β IL-2 Immunological response in vitro and in vivo studies Infection inhibitory concentration isolate lead life-threatening lung management mechanism of action mercuric chloride miRNA molecular docking MPro patients with COVID-19 performed RATs respiratory distress rutin SARS-CoV-2 SARS-CoV-2 main protease tested TNF-α Toxicity Treatment Viral viral infection were recorded [DOI] 10.3390/molecules26195844 PMC 바로가기 [Article Type] Article