S, spike – Communicable Diseases Research

Broad neutralization against SARS-CoV-2 variants induced by ancestral and B.1.351 AS03-Adjuvanted recombinant Plant-Derived Virus-Like particle vaccines

Article

Published on 2022-05-272023-06-15
Journal: Vaccine
[Category] COVID19(2023년), MERS, SARS,

Reduced amplification efficiency of the RNA-dependent-RNA-polymerase target enables tracking of the Delta SARS-CoV-2 variant using routine diagnostic tests

Article

Published on 2022-01-182022-10-04
Journal: Journal of virological methods
[Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제,

[키워드] 2019-nCoV amplification AUC, area under the curve can be used Cape conserved COVID-19 Cycle threshold value Delta delta variant diagnostic diagnostic test E, Envelope Efficiency GISAID, Global Initiative on Sharing All Influenza Data GTF, Gene Target Failure investigated IQR, interquartile range N, nucleocapsid NGS-SA, Network for Genomic Surveillance South Africa NHLS, National Health Laboratory Service Non-synonymous mutation Patient Prevalence RΔE, difference between the Ct values for RdRp and E-gene targets RdRp gene RdRp, RNA-dependent-RNA-polymerase reduced routine RT-PCR RT-PCR, reverse transcriptase polymerase chain reaction S, spike SARS-CoV-2 SARS-CoV-2 surveillance SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 Sequencing significant increase South Africa subset Surveillance tested the median the SARS-CoV-2 variants VOCs, Variants of Concern WGS, Whole Genome Sequencing while whole genome Whole genome sequencing
[DOI] 10.1016/j.jviromet.2022.114471 PMC 바로가기 [Article Type] Article

Lack of effects on female fertility or pre- and postnatal development of offspring in rats after exposure to AS03-adjuvanted recombinant plant-derived virus-like particle vaccine candidate for COVID-19

Article

Published on 2021-11-242023-06-15
Journal: Reproductive toxicology (Elmsford, N.Y.)
[Category] MERS, SARS,

[키워드] AS, adjuvant system AS03 CI, Confidence interval COVID-19 vaccine COVID-19, Coronavirus disease 2019 CoVLP, coronavirus-like particle CT, cytoplasmic tail DART developmental and reproductive toxicity Developmental and reproductive toxicity study EFD, embryofetal development ELISA, enzyme-linked immunosorbent assay Fertility GD, gestation day GLP, good laboratory practice GMT, geometric mean titer HCD, historical control data HRP, horse-radish peroxidase IM, intramuscular immunogenicity MRD, minimum required dilution OECD, organisation for economic co-operation and development PBS, phosphate buffered saline PND, postnatal day PPN, pre and postnatal Pregnancy QA, quality assurance RBD, receptor binding domain S, spike SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SD, study day SOP, standard operating procedure TM, transmembrane domainVLP virus-like particle virus-like particles
[DOI] 10.1016/j.reprotox.2021.11.006 PMC 바로가기 [Article Type] Article

Impaired innate antiviral defenses in COVID-19: Causes, consequences and therapeutic opportunities

Review

Published on 2021-11-092023-06-16
Journal: Seminars in Immunology
[Category] MERS, SARS,

[키워드] ACE-2, Angiotensin-converting enzyme 2 Antiviral innate immunity ARDS, acute respiratory distress syndrome CoV, coronavirus COVID-19 COVID-19, Coronavirus disease 2019 CRS, Cytokine release syndrome IFN, interferon IL, interleukin interferons IRF, Interferon regulatory factor ISG, Interferon-stimulated gene JAK, Janus kinase KPNA2, karyopherin α2 LY6E, lymphocyte antigen 6 complex, locus E MAVS, mitochondrial antiviral-signaling protein MDA5, melanoma-differentiated gene 5 MERS, Middle East respiratory syndrome N/L, neutrophil to lymphocyte NF-κB, nuclear factorκB NSP, non-structural protein OAS, Oligoadenylate synthetase ORF, open reading frame pDC, Plasmacytoid dendritic cell PRR, pattern-recognition receptor RIG, retinoic acid-inducible gene 1 RLR, RIG-I like receptor S, spike SARS-CoV-2 SARS, Severe acute respiratory syndrome STAT, Signal transducer and activator of transcription TBK1, TANK binding kinase 1 TLR, Toll-like receptor TMPRSS2, Transmembrane serine protease 2 TNF-α, tumor necrosis factor alpha
[DOI] 10.1016/j.smim.2021.101522 PMC 바로가기 [Article Type] Review

Severe Acute Respiratory Syndrome Coronavirus 2: Manifestations of Disease and Approaches to Treatment and Prevention in Humans

Review

Published on 2021-10-012023-06-14
Journal: Comparative medicine
[Category] MERS, SARS,

[키워드] ACE2, angiotensin-converting enzyme 2 ARDS, acute respiratory distress syndrome COVID-19, Coronavirus disease 2019 HCoV, human coronavirus IFN, interferon MERS, Middle East respiratory syndrome MIS-C, multisystem inflammatory syndrome in children RBD, receptor binding domain S, spike SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SARS, Severe acute respiratory syndrome TMPRSS2, type 2 transmembrane serine protease
[DOI] 10.30802/AALAS-CM-21-000011 PMC 바로가기 [Article Type] Review

Overview of Nonhuman Primate Models of SARS-CoV-2

Article

Published on 2021-10-012023-06-15
Journal: Comparative medicine
[Category] MERS, SARS,

The roles of lipids in SARS-CoV-2 viral replication and the host immune response

Review

Published on 2021-09-292022-10-29
Journal: Journal of Lipid Research
[Category] COVID-19,

[키워드] AA, arachidonic acid ACE2, angiotensin-converting enzyme 2 acute respiratory syndrome affecting Antiviral strategies ARDS, acute respiratory distress syndrome cell membrane cellular metabolism cholesterol coronavirus COVID-19 cysLT, cysteinyl leukotriene DC, dendritic cell eicosanoid Eicosanoids EPA, eicosapentaenoic acid Host immune response IAV, influenza A virus identify Infection IPr, IP receptor knowledge LA, linoleic acid Lipid lipid composition lipid mediator lipid metabolism Lipidomics LOX, lipoxygenase LPL, lysophospholipid mechanism membrane MERS-CoV, Middle East respiratory syndrome related coronavirus morbidity and mortality NPC1, NPC intracellular cholesterol transporter 1 offer PG, prostaglandin PGI₂, prostacyclin Phospholipids receptor regulate RO, replication organelle RSV, respiratory syncytial virus S, spike S1P, sphingosine-1-phosphate SARS-CoV-2 SARS-CoV-2 viral replication SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SK, sphingosine kinase sphingolipids SR-B1, scavenger receptor B type 1 therapeutic Tx, thromboxane viral burden viral entry viral infection viral life cycle virions virus
[DOI] 10.1016/j.jlr.2021.100129 PMC 바로가기 [Article Type] Review

Structures of synthetic nanobody–SARS-CoV-2 receptor-binding domain complexes reveal distinct sites of interaction

Research Article

Published on 2021-09-162022-10-30
Journal: The Journal of Biological Chemistry
[Category] COVID-19, MERS, SARS,

[키워드] accompanied ACE2, angiotensin-converting enzyme 2 acute respiratory syndrome angiotensin-converting enzyme 2 antibody BSA, buried surface area CCs, correlation coefficients CDR1, complementarity-determining region 1 CDR2, complementarity-determining region 2 CDR3, complementarity-determining region 3 complementarity-determining region complexes conformational coronavirus cryo-EM cryo-EM structure crystal structure Crystallography CTF, contrast transfer function difference domain enzyme explained FIVE indicate interact Interaction PDB, Protein Data Bank RBD RBD variant RBD, receptor-binding domain S-6P, HexaPro S S, spike SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SEC, size-exclusion chromatography single-domain antibody (sdAb, nanobody) Spike protein SPR, surface plasmon resonance Spread Structure structures surface plasmon resonance (SPR) sybody synthetic nanobodies the RBD the SARS-CoV-2 Trimeric spike protein unliganded variant X-ray
[DOI] 10.1016/j.jbc.2021.101202 PMC 바로가기 [Article Type] Research Article

An overview of human proteins and genes involved in SARS-CoV-2 infection

Review

Published on 2021-09-142023-07-01
Journal: Gene
[Category] SARS,

[키워드] (*), STOP codon ACE, angiotensin-converting enzyme ACE2, angiotensin converting enzyme-2 AP-MS, Affinity purification mass spectrometry ApoA1, apolipoprotein A1 Bioinformatics analysis CCR2, CC-chemokine receptor 2 CCRL2, C-C motif chemokine receptor like 2 COVID-19 COVID-19, Coronavirus disease 2019 CryoEM, Cryo-electron microscopy del, Deletion DNAH3, Dynein axonemal heavy chain 3 DPP, Dipeptidyl peptidase E, Envelope eQTL, Expression quantitative trait locus ERGIC, Endoplasmic reticulum Golgi intermediate compartment ESP, Exome Sequencing Project FOXP4, Forkhead box P4 fs, Frameshift mutation FYCO1, FYVE and coiled-coil domain autophagy adaptor 1 GNL3, G protein nucleolar 3 gnomAD, genome aggregation database GWAS GWAS, genome-wide association study HDL, high-density lipoprotein HGI, Host Genetics Initiative HLA, human leukocyte antigen HLA, human leukocyte antigens I/D, Insertion/Deletion ICU, Intensive care unit IFIT3, Interferon induced protein with tetratricopeptide repeats 3 IFN, Type I interferons IFNAR, Interferon-alpha/beta receptor IL, interleukin KEAP1, Kelch like ECH associated protein 1 KIT, KIT proto-oncogene, receptor tyrosine kinase LC, Liquid Chromatography LCN1P1, Lipocalin 1 pseudogene 1 LZTFL1, Leucine zipper transcription factor like 1 M, membrane MARK2, Microtubule affinity regulating kinase 2 MBL2, Mannose-binding lectin 2 MLKL, mixed lineage kinase domain-like protein N, nucleocapsid NAPSA, Napsin A aspartic peptidase NKRF, Nuclear factor-kB-repressing factor NSF, N-ethylmaleimide-sensitive factor nsps, Non-structural proteins OAS, Oligoadenylate synthase ORFs, open reading frames PALS1, Protein associated with LIN7 1, MAGUK family member PASC, post-acute sequelae of SARS-CoV-2 infection PGES-2, Prostaglandin E synthase type 2 PGLS, 6-Phosphogluconolactonase PLG, Plasminogen POFUT1, Protein O-Fucosyltransferase 1 POGLUT, Protein O-glucosyltransferase 1 precursor PRKACA, Protein kinase A catalytic subunit alpha PRPF3, U4/U6 small nuclear ribonucleoprotein Prp3 PRSS1, Serine protease 1 PTPN22, Protein tyrosine phosphatase non-receptor type 22 PUF60, Poly(U)-binding-splicing factor 60 PWAS, Protein-transcriptome-wide association study RBD, receptor binding domain RIPK1, Receptor-interacting serine/threonine protein kinase 1 S, spike SACM1L, SAC1 like phosphatidylinositide phosphatase SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SIGMAR1, Sigma nonopioid receptor 1 SLC6A20, Solute carrier family 6 member 20 SNP, single nucleotide polymorphism spTWAS, Splicing-transcriptome-wide association study SRP, Signal recognition particle SRPK1, SRSF protein kinase 1 TANK, TRAF family member associated NFKB activator TBK1, TANK binding kinase 1 TLE1, Transducin-like enhancer protein 1 TLR7, Toll-like receptor 7 TMPRSS2, Transmembrane Protease Serine 2 TOM, Translocase of the outer membrane TRAF, Tumor necrosis factor receptor-associated factor TRAF2, TNF receptor associated factor 2 TWAS TWAS, Transcriptome-wide association study TYK2, Tyrosine kinase 2 Virus-host interactome analyses WES, Whole exome sequencing WGS, Whole Genome Sequencing WNT3, Wnt family member 3 XCR1, X-C motif chemokine receptor 1 XYLT1, Xylosyltransferase 1
[DOI] 10.1016/j.gene.2021.145963 PMC 바로가기 [Article Type] Review

SARS-CoV-2, Zika viruses and mycoplasma: Structure, pathogenesis and some treatment options in these emerging viral and bacterial infectious diseases

Article

Published on 2021-09-032023-07-01
Journal: Biochimica et biophysica acta. Molecular basis of
[Category] SARS,

[키워드] ɣCoV, Gammacoronavirus αCoV, Alphacoronavirus βCoV, betacoronavirus δCoV, Deltacoronavirus ACE2, Angiotensin-converting enzyme 2 receptors ALA, Alpha-lipoic acid ARDS, acute respiratory distress syndrome Bacteria COVID-19, Coronavirus disease 2019 CoVs, coronaviruses CQ, Chloroquine DMVs, double-membrane vesicles E, Envelope ENac, Epithelial sodium channel ERS, Endoplasmic reticulum HCQ, hydroxychloroquine HGT, Horizontal gene transfer HI, Herd immunity IL, Interleukins Infection J-H, Jarisch-Herxheimer reactions M, membrane MHC, major histocompatibility complex morbidity N, nucleocapsid NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells nsp, Nonstructural proteins ORF, open reading frames pp1a, Polyproteins 1a pp1b, Polyproteins 1b Pregnancy RdRp, RNA-dependent RNA polymerase reproduction RTC, replicase-transcriptase complex S, spike TMPRSS2, type II transmembrane serine protease TNF-α, tumor necrosis factor-α virus WHO, World Health Organization ZIKV, Zika virus
[DOI] 10.1016/j.bbadis.2021.166264 PMC 바로가기 [Article Type] Article