Spread of Gamma (P.1) Sub-Lineages Carrying Spike Mutations Close to the Furin Cleavage Site and Deletions in the N-Terminal Domain Drives Ongoing Transmission of SARS-CoV-2 in Amazonas, Brazil브라질 아마조나스에서 SARS-CoV-2의 지속적인 전파를 유도하는 N-터미널 도메인의 삭제 및 푸린 절단 부위에 가까운 스파이크 돌연변이를 운반하는 감마(P.1) 하위 계통의 확산Research Article Published on 2022-02-232022-09-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, [키워드] affected analyzed antibody binding affinity Brazil Carrying concern coronavirus COVID-19 COVID-19 epidemic COVID-19 vaccines Ct value declined declining Deletion deletions diagnosed domain drive driven by driver Drivers effort Endemic ENhance evade Evidence Evolution of SARS-CoV-2 expected furin furin cleavage site Gamma genomic Genomic surveillance hosts human population human populations Immunity incidence increase in individual Lineage lineages Local mandatory molecular molecular dynamics Mutation N-terminal natural infection neutralizing antibody NTD number of infected P.1 P681H Pandemics parental Patient positive Prevalence reduce reveal risk S1/S2 junction SARS-CoV-2 SARS-CoV-2 genomic surveillance second wave significantly Site spike Spread Still subjects suggested Support Surveillance susceptible susceptible hosts the binding affinity the median the SARS-CoV-2 transmission of SARS-CoV-2 triggered vaccination vaccine breakthrough infections Vaccines variant variant gamma variants Viral Virus evolution viruses VoC Whole-genome sequence Δ144 [DOI] 10.1128/spectrum.02366-21 PMC 바로가기 [Article Type] Research Article
Capturing a Crucial ‘Disorder-to-Order Transition’ at the Heart of the Coronavirus Molecular Pathology—Triggered by Highly Persistent, Interchangeable Salt-BridgesArticle Published on 2022-02-162022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] anionic appear arginine baseline being binding catalytic cationic characteristic cleavage site coronavirus COVID-19 disorder disorder-to-order transition enthalpy entropy compensation entropy arrest events Evolution feature FLCS flexible furin cleavage Genome heart homologous Host increase in Interaction interactions Lineage Molecular pathology motif multiplicity offer persistent polybasic Protein proteolytic proteolytic cleavage residue respiratory viral diseases respiratory viruses S1/S2 junction salt-bridge salt-bridge dynamics SARS-CoV SARS-CoV-2 spike Spike–Furin interaction the SARS-CoV-2 Transmissibility [DOI] 10.3390/vaccines10020301 PMC 바로가기 [Article Type] Article
SARS‐CoV‐2′s claimed natural origin is undermined by issues with genome sequences of its relative strains Coronavirus sequences RaTG13, MP789 and RmYN02 raise multiple questions to be critically addressed by the scientific communitySARS-CoV-2의 천연 기원은 관련 균주의 게놈 서열 문제로 인해 훼손됨Think Again Published on 2021-05-272022-09-10 Journal: Bioessays [Category] 변종, [키워드] addressed Amino acid amino acid insertion Analysis claimed Contamination coronavirus Critical dataset Features furin furin cleavage site Genome genome sequence insertion metagenomic nucleotide open origin pandemic Pangolin CoV MP789 peer review polybasic PRRA insertion question raise RaTG13 reveal RmYN02 S1/S2 junction Sarbecoviruses SARS‐CoV‐2 SARS‐CoV‐2 Scientific community sequence Sequencing Spike protein strain Strains Support unique [DOI] 10.1002/bies.202100015 PMC 바로가기 [Article Type] Think Again
SARS‐CoV‐2′s claimed natural origin is undermined by issues with genome sequences of its relative strains Coronavirus sequences RaTG13, MP789 and RmYN02 raise multiple questions to be critically addressed by the scientific communityThink Again Published on 2021-05-272022-10-27 Journal: Bioessays [Category] COVID-19, [키워드] addressed amino acid insertion Analysis claimed Contamination coronavirus Critical dataset Features furin cleavage site Genome genome sequence insertion metagenomic origin pandemic Pangolin CoV MP789 peer review polybasic PRRA insertion question raise RaTG13 reveal RmYN02 S1/S2 junction SARS‐CoV‐2 SARS‐CoV‐2 Scientific community sequence Sequencing Spike protein strain Support unique [DOI] 10.1002/bies.202100015 PMC 바로가기 [Article Type] Think Again
SARS‐CoV‐2′s claimed natural origin is undermined by issues with genome sequences of its relative strains Coronavirus sequences RaTG13, MP789 and RmYN02 raise multiple questions to be critically addressed by the scientific communityThink Again Published on 2021-05-272022-10-27 Journal: Bioessays [Category] Coronavirus, COVID-19, Fulltext, SARS, 조류인플루엔자, [키워드] addressed amino acid insertion Analysis claimed Contamination coronavirus Critical dataset Features furin cleavage site Genome genome sequence insertion metagenomic origin pandemic Pangolin CoV MP789 peer review polybasic PRRA insertion question raise RaTG13 reveal RmYN02 S1/S2 junction SARS‐CoV‐2 SARS‐CoV‐2 Scientific community sequence Sequencing Spike protein strain Support unique [DOI] 10.1002/bies.202100015 PMC 바로가기 [Article Type] Think Again
Characterization of an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction of the spike protein스파이크 단백질의 S1/S2 접합부에 결실이 있는 약독화된 SARS-CoV-2 변이체의 특성화Article Published on 2021-05-132022-09-10 Journal: Nature Communications [Category] SARS, 변종, [키워드] adaptive cause characterization cleavage Critical Cytokines Deletion deletions disease Elevation hamster hamsters humans Immunity immunized immunogenicity immunopathology in vitro in vivo induce Infection key factor Live attenuated vaccines Lower respiratory tract mice motif neutralizing antibody observé parental Pathogenesis pathogenicity pathological change polybasic proinflammatory cytokines Protective Protein PRRA reduced replicate Replication reported respiratory respiratory tissues S1/S2 junction SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants spike Spike protein sterilizing immunity T cell T cell response the SARS-CoV-2 the spike protein Transmission Trigger triggers upper or lower respiratory tract Vero E6 VERO E6 cells viral infection virulence virus virus replication wild type zoonotic origin [DOI] 10.1038/s41467-021-23166-0 PMC 바로가기 [Article Type] Article
Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junctionArticle Published on 2020-05-042022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, SARS, [키워드] acquisition adaptive Amino acid Asymptomatic Body weight loss cleavage coronavirus COVID-19 Cross-species transmission Deletion detect evaluated examination hamster Human infected cases Infection Laboratory lung motif pandemic pathological change Point mutation positive Prevalence promoted purification Replication S1/S2 junction SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant selective specimen specimens Spike mutant Spike S1/S2 mutant the spike protein unique Vaccine variant variants VERO-E6 Vero-E6 cell virus infection wild type [DOI] 10.1080/22221751.2020.1756700 PMC 바로가기 [Article Type] Article