S1 subunit – Communicable Diseases Research

A case of COVID-19 reinfection in a hemodialysis patient: the role of antibody in SARS-CoV-2 infection

Article

Published on 2022-11-012022-11-15
Journal: CEN case reports
[Category] SARS, 진단,

Systematic analysis and comparison of O-glycosylation of five recombinant spike proteins in β-coronaviruses

Article

Published on 2022-10-162022-11-15
Journal: Analytica chimica acta
[Category] COVID19(2023년), SARS, 변종, 치료제,

The Spike-Stabilizing D614G Mutation Interacts with S1/S2 Cleavage Site Mutations To Promote the Infectious Potential of SARS-CoV-2 Variants

Article

Published on 2022-10-122022-11-16
Journal: Journal of Virology
[Category] COVID19(2023년), SARS, 변종,

[키워드] acute respiratory syndrome addition association carried Cell cleavage cleavage site cleaved coronavirus D614G D614G mutation Delta dependent on epistasis epistatic interaction evaluate expressing expression increasingly Mutation omicron pandemic pathogenic Potential Protein proteolytic proteolytic cleavage pseudovirions pseudovirus pseudoviruses remained resulting S1 subunit S1/S2 S1/S2 cleavage S1/S2 cleavage site SARS-CoV-2 SARS-CoV-2 variant Site spike spike mutation spikes Spread stabilizing effect successive wave Transmissibility variant variants variants of concern variants. Viral particles viral spike viral variant virions wild-type Wuhan
[DOI] 10.1128/jvi.01301-22 PMC 바로가기

Pre-existing anti-HCoV-OC43 immunity influences the durability and cross-reactivity of humoral response to SARS-CoV-2 vaccination

Article

Published on 2022-09-022022-11-15
Journal: Frontiers in Cellular and Infection Microbiology
[Category] SARS, 진단, 치료기술,

[키워드] Analysis anti-HCoV-OC43 anti-nucleoprotein anti-RBD antibodies antibody binding chemiluminescence immunoassay conducted coronavirus coronavirus vaccine correlation cross-protection cross-reactivity demonstrated detect ELISA enzyme-linked immunosorbent HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 humoral Humoral response IgG Immunity Immunoglobulin inactivated individuals influence neutralization Neutralization antibody neutralizing antibody Outbreaks performed positively correlated Protective protective immunity Protein pseudovirus S1 IgG S1 subunit SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine seasonal coronavirus seasonal human coronavirus. second vaccination statistically significant vaccination Vaccine vaccinee vaccinees viral neutralization
[DOI] 10.3389/fcimb.2022.978440 PMC 바로가기

Evidence of antibodies against SARS-CoV-2 in wild mustelids from Brittany (France)

Article

Published on 2022-09-012022-11-15
Journal: Transboundary and emerging diseases
[Category] COVID19(2023년), SARS, 진단, 치료기술,

Discovery of a Phage Peptide Specifically Binding to the SARS-CoV-2 Spike S1 Protein for the Sensitive Phage-Based Enzyme-Linked Chemiluminescence Immunoassay of the SARS-CoV-2 Antigen

SARS-CoV-2 항원의 민감한 파지 기반 효소 연결 화학발광 면역분석을 위한 SARS-CoV-2 스파이크 S1 단백질에 특이적으로 결합하는 파지 펩티드의 발견

Article

Published on 2022-08-232022-09-11
Journal: Analytical Chemistry
[Category] SARS, 치료기술, 치료제,

[키워드] albumin Amino acid amino acid sequence amplification antigen recognition binding site bovine bovine serum albumin chemiluminescence immunoassay conditions COVID-19 pandemic detect diagnose Dissociation constant Economy Effect exhibited expressing healthcare high affinity hydrogen hydrogen bond network hydrophobic immunoassay Interaction molecular docking N-terminal domain peptide peptides phage probe Protein pseudovirus S1 subunit Saliva SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 S1 SARS-CoV-2 S1 protein selective sensitive sensitivity serum albumin specificity spike Spread supported target target protein the S1 subunit the SARS-CoV-2 transducing transmembrane protein
[DOI] 10.1021/acs.analchem.2c01988 PMC 바로가기 [Article Type] Article

Acquisition of Furin Cleavage Site and Further SARS-CoV-2 Evolution Change the Mechanisms of Viral Entry, Infection Spread, and Cell Signaling

푸린 절단 부위의 획득 및 추가 SARS-CoV-2 진화는 바이러스 진입, 감염 확산 및 세포 신호 전달의 메커니즘을 변경합니다

Article

Published on 2022-08-102022-09-11
Journal: Journal of Virology
[Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단,

[키워드] ACE2 acquisition activate activating Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response alphavirus appear cathepsin Cathepsins Cell Cell fusion change coronavirus COVID COVID-19 disease Cytokines Deletion determined by endosome Entry mechanism entry pathway Evolution experimental system expressing S protein expression FCS furin furin cleavage furin cleavage site hallmark human population immune in vitro induce infected with SARS-CoV-2 infecting Infection inhibitor inhibitors lack leads Lineage mAbs mechanism media mRNA vaccines Neutralizing neutralizing monoclonal antibodies neutralizing monoclonal antibody pro-inflammatory cytokines pro-inflammatory response pseudoinfectious viruses pseudovirus pseudoviruses receptor released respiratory S protein S1 secretion S1 subunit SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 S protein secrete sera severe acute respiratory syndrome Coronavirus shown Site Spike protein Spread spreading Syncytia syncytium syncytium formation the S protein the S1 subunit TLR4 TMPRSS2 TMPRSS2 expression variant Viral viral evolution viral evolution. virus virus entry virus spread
[DOI] 10.1128/jvi.00753-22 PMC 바로가기 [Article Type] Article

Adjuvant-Protein Conjugate Vaccine with Built-In TLR7 Agonist on S1 Induces Potent Immunity against SARS-CoV-2 and Variants of Concern

S1에 TLR7 작용제가 내장된 아주반트-단백질 접합 백신은 SARS-CoV-2 및 우려 변종에 대한 강력한 면역을 유도합니다

Article

Published on 2022-07-082022-09-11
Journal: ACS Infectious Diseases
[Category] COVID19(2023년), SARS, 변종,

Use of Tumor Necrosis Factor-α Antagonists Is Associated With Attenuated IgG Antibody Response Against SARS-CoV-2 in Vaccinated Patients With Inflammatory Bowel Disease

종양 괴사 인자-α 길항제의 사용은 염증성 장 질환이 있는 백신 접종 환자에서 SARS-CoV-2에 대한 약화된 IgG 항체 반응과 관련이 있습니다

Observational Study

Published on 2022-07-052022-09-11
Journal: Frontiers in Immunology
[Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료기술,

[키워드] Against age antagonist antagonists anti-SARS-CoV-2 antibody anti-SARS-CoV-2 vaccination antibody Antibody concentrations Antibody titer Antibody titers Biologicals Blood blood sampling bowel Characteristics clinical Clinical characteristics Combination completion Concentration COVID-19 Crohn's disease defined demonstrated detectable disease Effect elapsed geometric geometric mean IBD IgG IgG antibodies IgG antibody IgG antibody titer IgG antibody titers immune response immunoassay immunomodulating Immunosuppressive medication immunosuppressive medications increased risk independent independent of Inflammatory Inflammatory bowel disease medication Microparticle monotherapy Most patients mRNA mRNA vaccines mRNA-based vaccine mRNA-based vaccines Multivariable models Patient patient age patients patients treated prospective observational cohort quantitative determination RBD receive receiving Receptor-binding domain regimen response S1 subunit sampling SARS-CoV-2 SARS-COV-2 infection Seroconversion serological response significantly lower Spike protein the receptor-binding domain the S1 subunit the spike protein titer TNF-α-antagonists treated Treatment Tumor ulcerative colitis vaccination vaccination. Vaccine vector was used were measured were recorded
[DOI] 10.3389/fimmu.2022.920333 PMC 바로가기 [Article Type] Observational Study

A novel high-throughput single B-cell cloning platform for isolation and characterization of high-affinity and potent SARS-CoV-2 neutralizing antibodies

고친화도 및 강력한 SARS-CoV-2 중화 항체의 분리 및 특성화를 위한 새로운 고처리량 단일 B 세포 클로닝 플랫폼

Article

Published on 2022-07-012022-09-12
Journal: Antiviral Research
[Category] COVID19(2023년), MERS, SARS, 진단,