Research Progress on Spike-Dependent SARS-CoV-2 Fusion Inhibitors and Small Molecules Targeting the S2 Subunit of SpikeReview Published on 2024-04-302024-09-05 Journal: Viruses [Category] update2024, [키워드] Arbidol Entry inhibitor fusion inhibitor molecular docking S2 segment S2 subunit SARS-CoV-2 Spike dependent surface plasmon resonance toremifene [DOI] 10.3390/v16050712 PMC 바로가기 [Article Type] Review
The Dual-Targeted Fusion Inhibitor Clofazimine Binds to the S2 Segment of the SARS-CoV-2 Spike ProteinArticle Published on 2024-04-202024-09-05 Journal: Viruses [Category] update2024, [키워드] Arbidol CHARMM Clofazimine fusion inhibitor molecular docking Nsp13 helicase S2 segment S2 subunit SARS-CoV-2 Spike-dependent surface plasmon resonance toremifene [DOI] 10.3390/v16040640 PMC 바로가기 [Article Type] Article
Novel S2 subunit-specific antibody with broad neutralizing activity against SARS-CoV-2 variants of concernImmunology Original Research Published on 2023-12-082024-09-05 Journal: Frontiers in immunology [Category] update2024, [키워드] antibody dependent cellular phagocytosis Broadly neutralizing antibody Inactivated virus S2 subunit SARS-CoV-2 [DOI] 10.3389/fimmu.2023.1307693 PMC 바로가기 [Article Type] Immunology Original Research
SARS-CoV-2 spike S2-specific neutralizing antibodiesarticle Published on 2023-06-152024-09-05 Journal: Emerging Microbes & Infections [Category] update2024, [키워드] antibody cocktail therapy neutralizing antibody S2 subunit SARS-CoV-2 Spike protein [DOI] 10.1080/22221751.2023.2220582 PMC 바로가기 [Article Type] article
Binding and neutralizing abilities of antibodies towards SARS-CoV-2 S2 domainSARS-CoV-2 S2 도메인에 대한 항체의 결합 및 중화 능력Article Published on 2022-11-302022-09-11 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibodies antibody B.1.1.7 B.1.351 B.1.617.2 B.1.621 binding binding activity carried conserved convalescent patient coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 determined by domain ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluated Evidence Immune escape immune protection mAb mAbs MERS MERS-CoV Middle East Middle East respiratory syndrome Middle East respiratory syndrome Coronavirus molecular monoclonal antibodies monoclonal antibody N Terminal N terminal domain NAbs Neutralization assay neutralization assay. Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody NTD P.1 Protein pseudo-virus RBD Receptor binding domain reported Research respiratory Result S protein S proteins S2 protein S2 subunit SARS-CoV SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 S SARS-CoV-2 S2 SARS-CoV-2 WT Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus significantly specific antibodies subunit target targets terminal Vaccine design variant variants wild-type [DOI] 10.1080/21645515.2022.2055373 PMC 바로가기 [Article Type] Article
Cellular interferon-gamma and interleukin-2 responses to SARS-CoV-2 structural proteins are broader and higher in those vaccinated after SARS-CoV-2 infection compared to vaccinees without prior SARS-CoV-2 infectionArticle Published on 2022-10-172022-11-15 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 진단, [키워드] assays BNT162b2 BNT162b2 vaccine class correlated demonstrated develop dose doses epitope exhibited Frequency greater healthcare worker healthy IFN-γ IgG response IL-2 IL2 Immunity individual infected with SARS-CoV-2 Infection Interferon-gamma interleukin-2 magnitude Moderna mRNA-1273 vaccine mononuclear cell mRNA-1273 N and M nine participant Participants PCR testing peptide Peripheral blood Pfizer-BioNTech positive Post-infection Proteins proteome repeated responders response responses against robust S glycoprotein S1 and S2 S2 subunit SARS-CoV-2 SARS-COV-2 infection structural protein subunit subunits T cell response T-cell Response the SARS-CoV-2 uninfected vaccination vaccinee was determined were expressed with COVID-19 [DOI] 10.1371/journal.pone.0276241 PMC 바로가기
Variation of Proteolytic Cleavage Sites towards the N-Terminal End of the S2 Subunit of the Novel SARS-CoV-2 Omicron Sublineage BA.2.12.1Article Published on 2022-09-082022-11-16 Journal: Molecules [Category] SARS, 변종, [키워드] accompanied Activation amino acid substitution BA.2.12.1 binding cathepsin G Cell cleavage site cleaved complex COVID-19 digested End furin immune response Infection MHC modify neutrophil Neutrophil elastase Neutrophils novel omicron Omicron variant Pathogens peptide polybasic Prevalence priming protease Protein proteinase proteinase 3 S1/S2 S2 antigen S2 subunit SARS-CoV-2 SARS-CoV-2 variant secrete sequence serine protease serine proteases Site Support T cell activation the major histocompatibility the S protein the Spike TMPRSS2 viral entry [DOI] 10.3390/molecules27185817 PMC 바로가기
Evidence of antibodies against SARS-CoV-2 in wild mustelids from Brittany (France)Article Published on 2022-09-012022-11-15 Journal: Transboundary and emerging diseases [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] antibody automated Brittany carried COVID-19 effective ELISA test epidemiological Epidemiosurveillance evidence of FIVE France French IgG Infection Martes martes Meles meles mustelids nucleocapsid qPCR Receptor binding domain S1 subunit S2 subunit SARS-CoV-2 serology seropositive Surveillance tested Viral protein western blot wildlife [DOI] 10.1111/tbed.14663 PMC 바로가기
Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical stem supersite of vulnerabilityArticle Published on 2022-09-012022-11-15 Journal: Structure (London, England : 1993) [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome Analysis antibodies antibody beta-coronavirus beta-coronaviruses Broadly neutralizing antibody conformations conserved coronavirus COVID-19 crystal structure elicit hydrophobic residue immunized indicated inhibiting Middle East mRNA murine neutralization neutralize neutralized Neutralizing recognizing S2 subunit S2-directed antibody Sarbecoviruses SARS-CoV SARS-CoV-2 SARS-CoV-2 variants spike syndrome the antibody the SARS-CoV-2 Vaccine design [DOI] 10.1016/j.str.2022.06.004 PMC 바로가기
Carbohydrate-binding protein from stinging nettle as fusion inhibitor for SARS-CoV-2 variants of concernArticle Published on 2022-08-302022-11-15 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 변종, 치료제, [키워드] addition Antiviral antiviral activity assays Beta binding block Cell cell cultures cell types cell-cell fusion cells circulating Coronaviruses Deletion Delta demonstrated fusion inhibitor Gamma inhibit inhibited inhibitor interface investigated lectin lung epithelial membrane fusion monomeric mutant N-acetylglucosamine (GlcNAc) N-glycosylation omicron Prevent Protein pseudotyped SARS-CoV-2 remained Replication replication of SARS-CoV-2 S2 subunit SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant Spike protein SPR subsequent surface plasmon resonance tested the spike protein UDA Urtica variant variants of concern variants of SARS-CoV-2 Vero E6 cell viral replication viral spike protein virus entry viruses Wuhan-Hu-1 [DOI] 10.3389/fcimb.2022.989534 PMC 바로가기