Insights from structure-activity relationships and the binding mode of peptidic α-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1article Published on 2024-04-302024-09-01 Journal: European Journal of Medicinal Chemistry [Category] 말라리아, [키워드] crystal structures malaria Pseudopeptides SAR SUB1 inhibitors α-ketoamides [Article Type] article
Biotin conjugates in targeted drug delivery: is it mediated by a biotin transporter, a yet to be identified receptor, or (an)other unknown mechanism(s)?article Published on 2023-11-132024-09-05 Journal: Journal of Enzyme Inhibition and Medicinal Chemistry [Category] update2024, [키워드] Biotin biotin receptor SAR SMVT Targeted drug delivery [DOI] 10.1080/14756366.2023.2276663 PMC 바로가기 [Article Type] article
Ligand-based design, synthesis, computational insights, and in vitro studies of novel N-(5-Nitrothiazol-2-yl)-carboxamido derivatives as potent inhibitors of SARS-CoV-2 main proteaseArticle Published on 2022-12-012023-07-10 Journal: Journal of Enzyme Inhibition and Medicinal Chemist [Category] COVID19(2023년), [키워드] anti-SARS-CoV-2 Mpro in silico in vitro N-(5-nitrothiazol-2-yl)-carboxamido derivatives SAR [DOI] 10.1080/14756366.2022.2105322 PMC 바로가기
Population-based screening in a municipality after a primary school outbreak of the SARS-CoV-2 Alpha variant, the Netherlands, December 2020-February 2021Article Published on 2022-10-272022-11-16 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] age Alpha Alpha variant Analysis caused children circulation Clinical symptoms confounders epidemiological link individual infected individual infected individuals Laboratory Lineage B.1.1.7 Netherlands not significantly different outbreak PCR Prevent public health measures questionnaire SAR SARS-CoV-2 SARS-CoV-2 variant School Schools secondary attack rate self-reported symptom sequence Sequencing spread to the mean the SARS-CoV-2 Transmission variant virus virus transmission was determined was used whole genome [DOI] 10.1371/journal.pone.0276696 PMC 바로가기
Synthesis and Anticancer and Antiviral Activities of C-2′-Branched ArabinonucleosidesArticle Published on 2022-10-192022-11-15 Journal: International Journal of Molecular Sciences [Category] 치료제, [키워드] accompanied activity Analysis anti-SARS-CoV-2 anti-tumor Antiviral antiviral activity Cell cell line Concentration coronavirus cytotoxicity Effect functional Generation time group growth HaCaT immortalized inhibitory activity investigated morphological changes MTT nucleoside nucleoside analogue outcome parameter photocatalytic thiol-ene reaction Reactions SAR SARS-CoV-2 SCC synthesis Time-lapse imaging tumor cells tumorous was obtained [DOI] 10.3390/ijms232012566 PMC 바로가기
Anticoagulants as Potential SARS-CoV-2 Mpro Inhibitors for COVID-19 Patients: In Vitro, Molecular Docking, Molecular Dynamics, DFT, and SAR StudiesArticle Published on 2022-10-132022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] addition Anticoagulant Anticoagulants carried Compound compounds conducted COVID-19 cytotoxicity demonstrated drug Dynamics eligible enzyme highest highest binding affinity Idraparinux in silico in silico approaches in vitro inhibitory inhibitory activity inhibitory concentration intrinsic investigated M pro molecular molecular docking MPro MTT performed Potential protease reference standard SAR SARS-CoV-2 SARS-CoV-2 Mpro screened sodium the SARS-CoV-2 thermodynamic [DOI] 10.3390/ijms232012235 PMC 바로가기
Chalcone-amide, a privileged backbone for the design and development of selective SARS-CoV/SARS-CoV-2 papain-like protease inhibitors선택적인 SARS-CoV/SARS-CoV-2 파파인 유사 프로테아제 억제제의 설계 및 개발을 위한 특권적인 백본인 Chalcone-amideReview Published on 2022-10-052022-09-11 Journal: European journal of medicinal chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] active site acute respiratory syndrome acute respiratory syndrome coronavirus amide antiviral immune responses backbone binding carbon caused chalcone Chalcone amide (N-benzylbenzamide) complex Compound coronavirus COVID-19 COVID-19 pandemic Critical crystal structure effort functional Genetic Host immune responses in some increase Infection inhibitor inhibitors inhibitory potency introduced maturation methyl group Papain Papain-like protease Papain-like protease (PLpro) performed PLPro polyproteins protease Protein Regulation Replication reported Research SAR SARS-CoV SARS-CoV-2 Screening selective shown similarity Structure therapeutic agent therapeutic agents Treatment treatment of COVID-19 understanding unique X-ray X-ray crystal structure. [DOI] 10.1016/j.ejmech.2022.114572 PMC 바로가기 [Article Type] Review
Household transmission of SARS-CoV-2 Omicron variant of concern subvariants BA.1 and BA.2 in DenmarkArticle Published on 2022-09-302022-11-16 Journal: Nature Communications [Category] SARS, 변종, [키워드] Breakthrough infection Contact Denmark Follow-up household household contact Infection omicron protective effect Ratio reduce SAR SARS Coronavirus SARS-CoV-2 secondary attack rate Secondary infection susceptibility Transmission dynamics transmission of SARS-CoV-2 vaccinated individuals vaccination variant [DOI] 10.1038/s41467-022-33498-0 PMC 바로가기
WCK 4034: A promising oxazolidinone for treating gram positive infectionsarticle Published on 2022-09-302024-09-01 Journal: Bioorganic & Medicinal Chemistry Letters [Category] 폐렴구균 감염증, [키워드] Gram positive infections MRSA oxazolidinones SAR WCK 4034 [Article Type] article
Increased household transmission and immune escape of the SARS-CoV-2 Omicron compared to Delta variantsArticle Published on 2022-09-292022-11-16 Journal: Nature Communications [Category] SARS, 변종, [키워드] 95% CI Contact Contact tracing Critical Delta delta variant groups growth household contact household transmission Immune escape Increased independent Infection lower risk omicron public health risk SAR SARS-CoV-2 secondary attack rate Spread susceptibility the epidemic the mean the SARS-CoV-2 Transmissibility understanding vaccination variant variants [DOI] 10.1038/s41467-022-33233-9 PMC 바로가기