An antibody that neutralizes SARS-CoV-1 and SARS-CoV-2 by binding to a conserved spike epitope outside the receptor binding motifArticle Published on 2022-10-282022-11-15 Journal: Science Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 receptor acute respiratory syndrome antibody Beta binding conserved coronavirus cryo-EM structure Delta delta variant demonstrated develop DNA epitope Evolution glycosylation site identify immune lung mice neutralize neutralizing activities omicron RBD Receptor binding domain receptor binding motif reduced SARS Coronavirus SARS coronaviruses SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2-specific B cell sequenced single-cell the RBD therapeutic variant Viral load viral spike protein were infected [DOI] 10.1126/sciimmunol.abp9962 PMC 바로가기
Posttranslational modifications optimize the ability of SARS-CoV-2 spike for effective interaction with host cell receptors번역 후 변형은 숙주 세포 수용체와의 효과적인 상호 작용을 위해 SARS-CoV-2 스파이크의 능력을 최적화합니다Article Published on 2022-07-122022-09-12 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome amplify antibody Complete conformational conserved construction coronavirus Coronaviruses Critical cryo-EM diagnostics docking domain domains effective flexible functional glycosylated glycosylation heterogeneity highlighting hinge region homology host cell host cell receptor host cell surface Interaction interactions Local maintain MD simulation membrane membrane-bound Microscopy Modification molecular molecular dynamics Protein receptor recognize reduced SARS coronaviruses SARS-CoV-2 SARS-CoV-2 spike single trajectory spike glycoprotein Spike protein structural dynamics. structural flexibility therapeutic Vaccines viral envelope viral infection virulence virus while [DOI] 10.1073/pnas.2119761119 PMC 바로가기 [Article Type] Article
Review of Sertoli cell dysfunction caused by COVID-19 that could affect male fertilityReview Published on 2022-02-012023-07-06 Journal: Zygote (Cambridge, England) [Category] COVID19(2023년), [키워드] COVID-19 germ cells male fertility SARS coronaviruses Sertoli cells. [DOI] 10.1017/S0967199421000320 [Article Type] Review
SNX27 suppresses SARS-CoV-2 infection by inhibiting viral lysosome/late endosome entry423 Published on 2022-01-132022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, [키워드] ACE2 ACE2 receptor acute respiratory syndrome analyses binding C terminal Cell cell entry cell surface pathway complex coronavirus cytosolic demonstrated domain endocytic Endocytic pathway enzyme functional fusing homeostasis host cell inhibiting Interaction Invasion membrane fusion motif physiological conditions plasma membrane Prevent Protein RBD recent regulate Regulation resulting retromer SARS coronaviruses SARS-CoV-2 SARS-COV-2 infection Significance SNX27 suppresse surface receptor therapeutic target type I viral entry virus was used [DOI] 10.1073/pnas.2117576119 PMC 바로가기 [Article Type] 423
Computational design of a neutralizing antibody with picomolar binding affinity for all concerning SARS-CoV-2 variants관련된 모든 SARS-CoV-2 변이체에 대한 피코몰 결합 친화성을 갖는 중화 항체의 전산 설계Article Published on 2022-01-012022-09-11 Journal: mAbs [Category] 변종, 진단, [키워드] Affinity maturation Alpha alpha and delta variants antibody bind binding affinities binding affinity binding the receptor-binding breadth broad-spectrum vaccine Broadly neutralizing antibody caused Computational antibody discovery concerning conserved coronavirus coronavirus disease Coronavirus disease 2019 Delta Delta variants domain emerging variants. exhibit exhibited glycoprotein highlighting identify Initially lead NAb NAbs neutralization activity Neutralizing Neutralizing antibodies neutralizing antibody pandemic potency RBD Receptor-binding domain SARS coronaviruses SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants spike glycoprotein the RBD Vaccine Vaccines variant variants virus Virus spike viruses wild-type SARS-CoV-2 [DOI] 10.1080/19420862.2021.2021601 PMC 바로가기 [Article Type] Article
Angiotensin-Converting Enzyme 2 (ACE2) in the Pathogenesis of ARDS in COVID-19COVID-19에서 ARDS의 발병에 대한 안지오텐신 전환 효소 2(ACE2)Review Published on 2021-12-222022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] ACE2 ACE2 expression acute lung injuries acute respiratory distress acute respiratory distress syndrome addition angiotensin Angiotensin II Angiotensin-converting enzyme angiotensin-converting enzyme 2 Apelin ARDS aspiration bradykinin carboxypeptidase caused cell entry coronavirus COVID-19 COVID-19 pathogenesis COVID-19 patients Critical degrade downregulate Efficacy emergence enzymatic activity enzyme exhibit form higher affinity higher infectivity Infection Interaction Mutation neutralize Neutralizing antibodies Novel coronavirus pandemic Pathogenesis pathology pneumonias Protective Protein receptor Receptor-binding domain recombinant ACE2 Renin – Angiotensin – Aldosterone System respiratory distress resulting SARS Coronavirus SARS coronaviruses SARS-CoV-2 SARS-CoV-2 receptor Sepsis similarity spike Spike protein syndrome the epidemic the receptor-binding domain the SARS-CoV-2 the Spike Transmissibility treating COVID-19 Vaccine variant variants Viral [DOI] 10.3389/fimmu.2021.732690 PMC 바로가기 [Article Type] Review
Inhibition of Viral Membrane Fusion by Peptides and Approaches to Peptide DesignReview Published on 2021-12-092022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] 6-helix bundle approach binding CD4 cellular plasma membrane coiled coil computation methods computational method conformational change database filoviruses fusion fusion protein gp120 Hepatitis herpesvirus HIV-1 Infection Influenza Influenza virus inhibit inhibition interfere involved membrane membrane fusion MERS peptide Peptide design Peptide inhibitor Protein receptor receptors SARS coronaviruses SARS-CoV-2 sequence Spike protein surface protein synthetic undergo viral envelope protein virus virus entry viruses [DOI] 10.3390/pathogens10121599 PMC 바로가기 [Article Type] Review
Decreased in-hospital mortality associated with aspirin administration in hospitalized patients due to severe COVID-19심각한 COVID-19로 인해 입원 환자에서 아스피린 투여와 관련된 병원 내 사망률 감소Article Published on 2021-09-012022-09-11 Journal: Journal of medical virology [Category] SARS, 치료제, [키워드] administration adverse effect adverse effects antiplatelet Aspirin association caused center Clinical data Cohort cohort study Comorbidities coronavirus disease Coronavirus disease 2019 COVID-19 COX Decreased demographics demonstrated Diagnosis Efficacy evaluate Hospitalization Hospitalized hospitalized patient hospitalized patients hypercoagulability Imam in-hospital mortality independent Iran Mortality mortality rate multivariate outcome Patient prevalent Primary outcome Randomized controlled trial receiving reduction in Result risk SARS coronaviruses severe COVID-19 significant decrease Tehran the patient therapy Thromboembolism thrombosis were recorded with COVID-19 [DOI] 10.1002/jmv.27053 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Impairs Dendritic Cells and Regulates DC-SIGN Gene Expression in TissuesSARS-CoV-2는 수지상 세포를 손상시키고 조직에서 DC-SIGN 유전자 발현을 조절합니다Article Published on 2021-08-262022-09-12 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 진단, [키워드] ACE2 airway ANXA1 Blood CD22 cDCs coronavirus SARS-CoV-2 COVID-19 COVID-19 patient COVID-19 patients dataset DC-SIGN DCs dendritic cell dendritic cells downregulation Gene Expression healthy controls host receptor Host receptors immature immune responses indicate innate immune response innate immune responses L-SIGN lung lung DC Lungs MHCII Mild modulation observation pathogenic pDCs plasmacytoid DC plasmacytoid DCs provide SARS Coronavirus SARS coronaviruses SARS-CoV-2 screened Severe case severe cases severe COVID-19 SIGN Single Cell stimulate transcriptomic upper airway [DOI] 10.3390/ijms22179228 PMC 바로가기 [Article Type] Article
Differential susceptibility of SARS‐CoV‐2 in animals: Evidence of ACE2 host receptor distribution in companion animals, livestock and wildlife by immunohistochemical characterisation동물에서 SARS-CoV-2의 감수성: 면역조직화학적 특성화에 의한 반려동물, 가축 및 야생동물에서 ACE2 숙주 수용체 분포의 증거Original Article Published on 2021-07-262022-09-10 Journal: Transboundary and emerging diseases [Category] COVID19(2023년), MERS, SARS, 치료기술, [키워드] absence ACE2 ACE2 expression Acinonyx addition anatomical angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 binding bronchiolar cats cattle characterisation cheetah coronavirus distribution Enterocyte enterocytes enzyme Eptesicus European badger Evidence evidence of felids Felis ferret ferrets gastrointestinal tracts histological Host host cell host cell membrane host receptor host susceptibility humans IHC immunohistochemistry in some indicated information intestine limit lion Lower respiratory tract lung Lungs Mesocricetus microvillus mink mustelids nasal nasal mucosa nasal turbinate Neovison Ovis primates Protein receptor respiratory respiratory and gastrointestinal tracts respiratory tract respiratory tracts SARS Coronavirus SARS coronaviruses SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 serotine bat sheep species susceptibility tiger tissue tissue tropism Trachea Viral viral infection zoonoses [DOI] 10.1111/tbed.14232 PMC 바로가기 [Article Type] Original Article