Human microbiota dysbiosis after SARS-CoV-2 infection have the potential to predict disease prognosisarticle Published on 2023-11-292024-09-05 Journal: BMC Infectious Diseases [Category] update2024, [키워드] Human microbiota Key microbiota machine learning SARS-CoV-2/COVID-19 α-diversity [DOI] 10.1186/s12879-023-08784-x PMC 바로가기 [Article Type] article
Drug-drug interactions of ritonavir-boosted SARS-CoV-2 protease inhibitors in solid organ transplant recipients: experience from the initial use of lopinavir-ritonavirResearch Note Published on 2023-01-112024-09-05 Journal: Clinical microbiology and infection : the official [Category] update2024, [키워드] clinical research/practice drug interaction Immunosuppressant Lopinavir/ritonavir SARS-CoV-2/COVID-19 solid organ transplantation [DOI] 10.1016/j.cmi.2023.01.002 PMC 바로가기 [Article Type] Research Note
Seroconversion rate after primary vaccination with two doses of BNT162b2 versus mRNA-1273 in solid organ transplant recipients: a systematic review and meta-analysis고형장기 이식 환자에서 2회 BNT162b2 대 mRNA-1273 1차 백신접종 후 혈청전환율: 체계적 고찰 및 메타분석Meta-Analysis Published on 2022-07-262022-09-12 Journal: Nephrology, dialysis, transplantation : official p [Category] MERS, 진단, [키워드] 95% CI acute respiratory syndrome antibody Antibody Response Antibody titer Antibody titers BNT162b2 calculate Cochrane Library confidence interval coronavirus described domain dose eligible General population indicate literature review Messenger RNA Meta-analysis mRNA mRNA vaccines mRNA-1273 of BNT162b2 Patient performed RBD recipient recipients reported Research SARS-CoV-2/COVID-19 seroconversion rate significantly higher solid organ transplant Solid organ transplant recipients SOT Spike protein systematic review the antibody response vaccination Vaccine was performed Web of Science [DOI] 10.1093/ndt/gfac174 PMC 바로가기 [Article Type] Meta-Analysis
Survey of current transplant center practices regarding COVID-19 vaccine mandates in the United StatesArticle Published on 2022-06-012023-07-08 Journal: American journal of transplantation : official jou [Category] COVID19(2023년), [키워드] Ethics ethics and public policy infection and infectious agents - viral Infectious disease patient safety SARS-CoV-2/COVID-19 solid organ transplantation Vaccine [DOI] 10.1111/ajt.16995 PMC 바로가기
A wastewater-based epidemic model for SARS-CoV-2 with application to three Canadian citiesArticle Published on 2022-06-012023-07-08 Journal: Epidemics [Category] COVID19(2023년), [키워드] Environmental surveillance epidemic model SARS-CoV-2/COVID-19 wastewater [DOI] 10.1016/j.epidem.2022.100560 PMC 바로가기
Impact of natural selection on global patterns of genetic variation and association with clinical phenotypes at genes involved in SARS-CoV-2 infectionSARS-CoV-2 감염과 관련된 유전자의 유전적 변이 및 임상 표현형과의 연관성에 대한 자연 선택의 영향Article Published on 2022-05-242022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종, [키워드] 1000 Genomes Project ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive African African diversity Amino acid amino acid change analyzed angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Antigen association caused clinical phenotype clinical phenotypes complex coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 dipeptidyl peptidase Dipeptidyl peptidase 4 DPP4 Electronic health record Electronic health records enzyme European Genetic genetic diversity genetic variants Genetic variation Genome genomic Haplotype haplotypes Health host gene host genes Human identify Impact in some individual investigated involved Lineage locus LY6E lymphocyte minor allele frequency natural selection nonsynonymous variant pandemic patients with COVID-19 phenotype phenotype association. populations Positive selection protease Protein provide regulatory region SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2/COVID-19 Serine serine 2 severe acute respiratory syndrome Coronavirus target targets TMPRSS2 transmembrane transmembrane protease serine 2 variant Variation viral infections viruses [DOI] 10.1073/pnas.2123000119 PMC 바로가기 [Article Type] Article
A third dose of SARS-CoV-2 vaccine increases neutralizing antibodies against variants of concern in solid organ transplant recipientsArticle Published on 2022-04-012023-07-07 Journal: American journal of transplantation : official jou [Category] COVID19(2023년), [키워드] basic (laboratory) research/science immunobiology infection and infectious agents - viral Infectious disease SARS-CoV-2/COVID-19 solid organ transplantation translational research/science Vaccine [DOI] 10.1111/ajt.16933 PMC 바로가기
Randomised controlled trial of intravenous nafamostat mesylate in COVID pneumonitis: Phase 1b/2a experimental study to investigate safety, Pharmacokinetics and PharmacodynamicsCOVID 폐렴에서 정맥내 나파모스타트 메실레이트의 무작위 대조 시험: 안전성, 약동학 및 약력학을 조사하기 위한 1b/2a상 실험 연구Clinical Trial Published on 2022-02-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), MERS, SARS, 바이오마커, 신약개발, 임상, 치료제, [키워드] 95% CI Administered adverse events Analysis Anti-inflammatory Anticoagulant anticoagulant effect anticoagulant effects antiviral activity assigned average characterisation Controlled trial COVID COVID-19 COVID19 creatinine credible interval demonstrated dose Edinburgh Endpoint endpoints Evidence evidence of Hospital stay hospitalised hospitalised patient Hospitalised patients inactive independent Infectious diseases intravenous intravenous infusion manuscript maximum mean difference mesylate metabolites nafamostat Nafamostat mesylate observé Odds ratio open open label Oxford oxygen Patient patients Pharmacodynamics pharmacokinetics phase Phase 2 PK data plasma platform Pneumonitis Primary outcome Primary outcomes progressed randomised randomised controlled trial Randomly rate ratio receive reported Repurposed drug Research respiratory Respiratory medicine response SARS-CoV-2/COVID-19 Seven significantly higher significantly more SOC Standard of care statistically significant difference therapy Tolerability Total Total manuscript word count. Trial university with COVID-19 [DOI] 10.1016/j.ebiom.2022.103856 PMC 바로가기 [Article Type] Clinical Trial
Progressive deterioration of the upper respiratory tract and the gut microbiomes in children during the early infection stages of COVID-19Research article Published on 2021-09-012022-10-05 Journal: Journal of genetics and genomics = Yi chuan xue ba [Category] 유전자 메커니즘, [키워드] acute respiratory syndrome affected Alter children clinical recovery Complication coronavirus coronavirus disease Course COVID-19 Deterioration discharge Disturbed Dysbiosis early infection evaluated Gut gut microbiota Health hospital individuals Infection less longitudinal manifested mechanism Microbiome morbidity and mortality nine persist predisposition Progressive Pseudomonas risk SARS-CoV-2 SARS-CoV-2/COVID-19 Stage susceptible upper respiratory Upper respiratory microbiome upper respiratory tract [DOI] 10.1016/j.jgg.2021.05.004 [Article Type] Research article
Recent progress on rapid SARS-CoV-2/COVID-19 detection by CRISPR-Cas13-based platformsReview Published on 2021-08-012023-06-19 Journal: Drug discovery today [Category] MERS, SARS, [키워드] Collateral cleavage CRISPR-Cas13 point-of-care testing rapid detection SARS-CoV-2/COVID-19 SHERLOCK [DOI] 10.1016/j.drudis.2021.06.005 PMC 바로가기 [Article Type] Review