The Nucleocapsid Proteins of SARS-CoV-2 and Its Close Relative Bat Coronavirus RaTG13 Are Capable of Inhibiting PKR- and RNase L-Mediated Antiviral Pathwaysarticle Published on 2023-05-082024-09-05 Journal: Microbiology Spectrum [Category] update2024, [키워드] double-stranded RNA virus G3BP1 PKR RaTG13 RNase L SARS-CoV-2 nucleocapsid vaccinia virus E3 [DOI] 10.1128/spectrum.00994-23 PMC 바로가기 [Article Type] article
Folic acid: a potential inhibitor against SARS-CoV-2 nucleocapsid protein엽산: SARS-CoV-2 뉴클레오캡시드 단백질에 대한 잠재적 억제제Article Published on 2022-12-012022-09-11 Journal: Pharmaceutical Biology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, [키워드] analysed Analysis antagonist antiviral effects antivirus association cellular Chinese Chinese medicine Compound Concentration coronavirus disease Coronavirus disease 2019 COVID-19 Data analysis docking drug target experiment Folic acid Genes global pandemic Host hub genes identify inhibit inhibition inhibitor involved material mCherry mCherry expression mechanism molecular molecular docking network pharmacology Nucleocapsid phosphoprotein Phosphoprotein Protein Regulatory RNA interference RNAi SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 nucleocapsid screened shown target targets therapeutic target Traditional Traditional Chinese medicine virus [DOI] 10.1080/13880209.2022.2063341 PMC 바로가기 [Article Type] Article
Rapid determination of SARS-CoV-2 nucleocapsid proteins based on 2D/2D MXene/P-BiOCl/Ru(bpy)32+ heterojunction composites to enhance electrochemiluminescence performanceArticle Published on 2022-11-222022-11-15 Journal: Analytica chimica acta [Category] COVID19(2023년), SARS, 치료기술, [키워드] “Signal on-off” ECL immunosensors. acute respiratory syndrome applied Atypical caused Cluster Combination Concentration contagious coronavirus COVID-19 detect Diagnostic method disease ECL Electrochemiluminescence ENhance exhibit human serum hydrophilicity IMPROVE intrinsic limit of detection linear MXene/P–BiOCl/Ru(bpy)(3)(2+) novel coronavirus disease oxychloride Pneumonia promote Protein Rapid SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 nucleocapsid protein signal Signal amplifier and co-reaction accelerator [DOI] 10.1016/j.aca.2022.340522 PMC 바로가기
Discriminative electrochemical biosensing of wildtype and omicron variant of SARS-CoV-2 nucleocapsid protein with single platformArticle Published on 2022-11-152022-11-15 Journal: Analytical biochemistry [Category] SARS, 변종, 진단, 치료기술, [키워드] antibody Antigen COVID-19 detect Electrochemical biosensing platforms evaluated linear Microscopy nasopharyngeal swab sample nucleocapsid antigen Nucleocapsid antigen protein omicron Omicron variant platform produced Protein SARS-CoV-2 SARS-CoV-2 nucleocapsid the SARS-CoV-2 voltammetry wildtype X-ray X-ray spectroscopy [DOI] 10.1016/j.ab.2022.114898 PMC 바로가기
Investigation of SARS-CoV-2 nucleocapsid protein interaction with a specific antibody by combined spectroscopic ellipsometry and quartz crystal microbalance with dissipationArticle Published on 2022-11-152022-11-15 Journal: Journal of Colloid and Interface Science [Category] COVID19(2023년), SARS, 진단, [키워드] affected antibody Antibody and antigen interaction Antibody bivalent binding Antibody flexibility Antigen binding complex conformational change distribution Fab fragment immune complex Immune complexes immunosensor information Interaction investigation polyclonal produced Protein Quantitative quartz Quartz crystal microbalance with dissipation (QCM-D) Registered SARS-CoV-2 SARS-CoV-2 nucleocapsid Spectroscopic ellipsometry. was determined was used [DOI] 10.1016/j.jcis.2022.06.119 PMC 바로가기
Magnetic/fluorescent dual-modal lateral flow immunoassay based on multifunctional nanobeads for rapid and accurate SARS-CoV-2 nucleocapsid protein detectionArticle Published on 2022-11-152022-11-15 Journal: Analytica chimica acta [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy addition diagnose diagnosis of SARS-CoV-2 early stage effective Elasticity fluorescent Infection Lateral lateral flow immunoassay LFIA limit of detection Magnetic/fluorescent dual-modal multifunctional Multifunctional nanobeads PEI Protein Quantitative analysis resulting Saliva SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 nucleocapsid protein SARS-CoV-2 pandemic sensitivity [DOI] 10.1016/j.aca.2022.340486 PMC 바로가기
Induction of pulmonary HLA-G expression by SARS-CoV-2 infectionArticle Published on 2022-11-052022-11-15 Journal: Cellular and Molecular Life Sciences [Category] SARS, 치료기술, 치료제, [키워드] accompanied Antigen Autopsy biopsies CD8 Cell changes in correlated distribution epithelial cell Evidence expressed expression expression level Frequency heart muscle HLA-G Hyperactivation Immune cell Immune cell infiltration immune cells Immune escape immune response induction information kidney leukocyte lung lung alveolar lung epithelia lung epithelial cell lung tissue Macrophage marker microRNA miRNA miRNA expression modulating organs other organ patients protein expression SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 nucleocapsid SARS-CoV-2- SARS-CoV-2-infected patient specimen Spike protein surgical T cell responses T cells therapeutic target tissue tissues Treatment Tumor virus-infected cells while [DOI] 10.1007/s00018-022-04592-9 PMC 바로가기
Discovery and structural characterization of chicoric acid as a SARS-CoV-2 nucleocapsid protein ligand and RNA binding disruptorArticle Published on 2022-11-022022-11-15 Journal: Scientific Reports [Category] SARS, 치료제, [키워드] Antiviral antivirals binding C-terminal domain cell cultures compounds coronavirus Critical CTD disrupt Genome identify information isothermal titration calorimetry Ligand ligands N protein N-protein NMR nucleocapsid Protein reduced representing RNA SARS-CoV-2 nucleocapsid SARS-CoV-2 replication small molecule the N protein the SARS-CoV-2 the SARS-CoV-2 genome Transcription [DOI] 10.1038/s41598-022-22576-4 PMC 바로가기
SARS-CoV-2 Infection Causes Hyperglycemia in CatsArticle Published on 2022-11-012022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 치료기술, 치료제, [키워드] ACE2 acute respiratory syndrome blood glucose cats cause Cell cells conducted contribute coronavirus coronavirus disease COVID-19 diabete diabetes dysregulation Endocrine Ex vivo exhibited experiment experimental evidence expressed High dose hyperglycemia immune protection immunized in vivo infect Infection islet Isolated lack pancrea pancreas pancreatic Patient Protein Research researcher SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 RNA Spike protein staining tissue viruses [DOI] 10.1093/infdis/jiac143 PMC 바로가기
Seroprevalence, correlates and kinetics of SARS-CoV-2 nucleocapsid IgG antibody in healthcare workers and nonclinical staff at a tertiary hospital: A prevaccine census studyArticle Published on 2022-10-272022-11-15 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 진단, [키워드] adjusted age Antibody test Asymptomatic category Chemiluminescent assay Comorbidity conducted confidence interval country COVID-19 COVID-19 vaccination determine effective enrolled General population HCW healthcare worker hospital hospital management IgG IgG antibody IgG test implementation increased risk Infection lowest mild symptoms Odds ratio over positive positive PCR test positive SARS-CoV-2 PCR predictor Prevalence preventive measure SAR-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid sensitivity Seroprevalence Sex staff Symptoms university was performed [DOI] 10.1371/journal.pone.0267619 PMC 바로가기