SARS-CoV-2 pathogenesis – Communicable Diseases Research

Immunological and Pathological Peculiarity of Severe Acute Respiratory Syndrome Coronavirus 2 Beta Variant

Article

Published on 2022-10-262022-11-15
Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단,

Arylcoumarin perturbs SARS-CoV-2 pathogenesis by targeting the S-protein/ACE2 interaction

Article

Published on 2022-10-112022-11-16
Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종,

SARS-CoV-2 variant spike and accessory gene mutations alter pathogenesis

Article

Published on 2022-09-132022-11-16
Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종,

Identification of a novel immune-inflammatory signature of COVID-19 infections, and evaluation of pharmacokinetics and therapeutic potential of RXn-02, a novel small-molecule derivative of quinolone

Research article

Published on 2022-09-012022-10-05
Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료기술, 치료제,

[키워드] A549 activity acute respiratory syndrome addition Analysis AUC binding binding affinity Bioinformatics analysis candidate caused Cell cell line clinical investigation Colon conducted coronavirus Coronavirus disease 2019 COVID-19 COVID-19 (Coronavirus disease 2019) COVID-19 infections dataset drug drug target effector memory Efficacy evaluated exhibited FIVE gene signature global pandemic human lung IC50 identification immune immunomodulation immunomodulatory immunosuppressive in vitro in vivo Inflammation Inflammatory Lungs peak plasma concentration pharmacokinetics positive-sense RNA virus respiratory infection SARS-CoV-2 SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) SARS-CoV-2 drug SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 pathogenesis SARS-CoV-2-infected patient suggested T cell therapeutic options therapeutic potential therapy threat transcriptomic translation translational vaccine candidates value
[DOI] 10.1016/j.compbiomed.2022.105814 [Article Type] Research article

Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection

Article

Published on 2022-09-012022-11-16
Journal: Structure (London, England : 1993) [Category] COVID19(2023년), SARS, 변종,

Papain-like protease of SARS-CoV-2 inhibits RLR signaling in a deubiquitination-dependent and deubiquitination-independent manner

Article

Published on 2022-08-122022-10-06
Journal: Frontiers in Immunology [Category] SARS, 진단,

[키워드] acute respiratory syndrome antiviral therapy attenuate catalytic component components contribute Coronavirus-2 COVID-19 Critical cysteine demonstrated Deubiquitination disease severity domain DUB dysregulated Effect Efficiency exhibited greater IFN IFN response independent inhibit inhibitory activity inhibitory effect innate immune interferon IRF3 IκBα MAVS mechanism mechanisms mutant Papain-like protease PLPro protease receptor reduced reported required residue response responses RIG-I RLR signaling SARS-CoV SARS-CoV-2 SARS-CoV-2 pathogenesis Sendai virus Signal transduction Signaling signaling pathway significantly specificity suppressed target TBK1 TRAF3 Traf6
[DOI] 10.3389/fimmu.2022.947272 PMC 바로가기 [Article Type] Article

Acquisition of Furin Cleavage Site and Further SARS-CoV-2 Evolution Change the Mechanisms of Viral Entry, Infection Spread, and Cell Signaling

푸린 절단 부위의 획득 및 추가 SARS-CoV-2 진화는 바이러스 진입, 감염 확산 및 세포 신호 전달의 메커니즘을 변경합니다

Article

Published on 2022-08-102022-09-11
Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단,

[키워드] ACE2 acquisition activate activating Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response alphavirus appear cathepsin Cathepsins Cell Cell fusion change coronavirus COVID COVID-19 disease Cytokines Deletion determined by endosome Entry mechanism entry pathway Evolution experimental system expressing S protein expression FCS furin furin cleavage furin cleavage site hallmark human population immune in vitro induce infected with SARS-CoV-2 infecting Infection inhibitor inhibitors lack leads Lineage mAbs mechanism media mRNA vaccines Neutralizing neutralizing monoclonal antibodies neutralizing monoclonal antibody pro-inflammatory cytokines pro-inflammatory response pseudoinfectious viruses pseudovirus pseudoviruses receptor released respiratory S protein S1 secretion S1 subunit SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 S protein secrete sera severe acute respiratory syndrome Coronavirus shown Site Spike protein Spread spreading Syncytia syncytium syncytium formation the S protein the S1 subunit TLR4 TMPRSS2 TMPRSS2 expression variant Viral viral evolution virus virus entry virus spread
[DOI] 10.1128/jvi.00753-22 PMC 바로가기 [Article Type] Article

SARS-CoV-2-positive patients display considerable differences in proteome diversity in urine, nasopharyngeal, gargle solution and bronchoalveolar lavage fluid samples

SARS-CoV-2-양성 환자는 소변, 비인두, 양치액 및 기관지폐포 세척액 샘플에서 단백질체 다양성에 상당한 차이를 나타냅니다.

Article

Published on 2022-08-082022-09-11
Journal: PLoS ONE [Category] SARS, 유전자 메커니즘, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 BALF Beijing Bronchoalveolar lavage fluid center chance change characterized Charle China collected coronavirus coronavirus 2 database demonstrated Department downloaded followed by gargle gargle solution Germany Human human body in urine individual infected with SARS-CoV-2 Infection information investigated Mayo Clinic Medicine nasopharyngeal nasopharyngeal sample Nasopharyngeal samples pathology peptide Protein Proteins proteome proteomic proteomics respiratory SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 proteome SARS-CoV-2 virus SARS-CoV-2 viruses SARS-CoV-2-positive patient SARS-CoV-2-positive patients Science secreted seropositive individuals Severe acute respiratory syndrome significantly more solution status technology the SARS-CoV-2 virus UniProt unique university Urine USA virus viruses was used while
[DOI] 10.1371/journal.pone.0271870 PMC 바로가기 [Article Type] Article

Identifying novel host-based diagnostic biomarker panels for COVID-19: a whole-blood/nasopharyngeal transcriptome meta-analysis

COVID-19에 대한 새로운 호스트 기반 진단 바이오마커 패널 식별: 전혈/비인두 전사체 메타 분석

Meta-Analysis

Published on 2022-08-032022-09-11
Journal: Molecular Medicine [Category] SARS, 바이오마커, 유전자 메커니즘, 치료기술,

[키워드] Accuracy acute respiratory illness acute respiratory illnesses Analysis applied ARI bioinformatics Biomarker Blood Cell cell cycle Characteristics Combination complementary controls COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patients COVID-19 sample cross cytokine cytokine production Data integration dataset Defense detect diagnose diagnostic diagnostic biomarker Diagnostic biomarkers Diseases eight enhancement feature gene expression profile Gene ontology HCs healthy control healthy controls Host host gene host response identifying Immune cell improvement Improvements independent indicated induce Infection Inflammatory interferon introduced lack machine learning algorithm Machine learning algorithms marker Meta-analysis nasopharyngeal Nasopharyngeal swab Ontology Pathogenesis pathway pathway enrichment patients with COVID-19 proportion Random forest respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis selected swab sample System Systems biology Transcriptome upregulation Viral virus Whole blood
[DOI] 10.1186/s10020-022-00513-5 PMC 바로가기 [Article Type] Meta-Analysis

Host genomics of SARS-CoV-2 infection

SARS-CoV-2 감염의 숙주 유전체학

Review

Published on 2022-08-012022-09-11
Journal: European Journal of Human Genetics [Category] COVID19(2023년), SARS, 바이오마커, 변종, 신약개발, 유전자 메커니즘, 치료제,

[키워드] acute infection approach approaches association Asymptomatic causal variant complications COVID-19 COVID-19 pneumonia demographic disease disease severity downstream Exome explain exploration Factor fraction functional genetic determinant genetic determinants Genetic variant Genome sequencing Genome-wide association studies genomic study highlighting host-virus interactions Human human genetic variation immune function individuals International involved life-threatening locus management Mild outcome pandemic Pathogenesis pathway Pathways Pneumonia Region required SARS-CoV-2 SARS-CoV-2 infected individuals SARS-COV-2 infection SARS-CoV-2 pathogenesis severe cases shown therapeutic targets type I interferon type I interferon response Variability with COVID-19
[DOI] 10.1038/s41431-022-01136-4 PMC 바로가기 [Article Type] Review