High diversity in Delta variant across countries revealed by genome‐wide analysis of SARS‐CoV‐2 beyond the Spike protein스파이크 단백질을 넘어 SARS-CoV-2의 게놈 전체 분석에 의해 밝혀진 국가 간 Delta 변이체의 높은 다양성Article Published on 2022-02-142022-09-10 Journal: Molecular Systems Biology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] Alpha Alpha variant Amino acid Analysis Beta Bioinformatics analysis contagious coronavirus country Delta delta variant dominant feature focus genomes highlight identify life list Microbiology, Virology & Host Pathogen Interaction Missense mutation Mutation mutations neutralization nucleocapsid other variant other variants pathogenic performed Prevalence prevalent prevalent strain Protein Proteins proteome public health reduced SARS‐CoV‐2 SARS‐CoV‐2 genome SARS‐CoV‐2 genomes SARS‐CoV‐2 protein SARS‐CoV‐2 proteins SARS‐CoV‐2 spike Spike protein susceptibility systematic analysis the Spike Transmissibility Vaccines Viral viral loads while [DOI] 10.15252/msb.202110673 PMC 바로가기 [Article Type] Article
Molecular evidence suggesting the persistence of residual SARS‐CoV‐2 and immune responses in the placentas of pregnant patients recovered from COVID‐19Original Article Published on 2021-07-222022-10-31 Journal: Cell Proliferation [Category] COVID-19, SARS, [키워드] activated amniotic Blood CD14+ clinically controls COVID‐19 COVID‐19 cytokine cytokine level Diagnosis discharged patient Evidence FIVE fluctuation immune immune response immunostaining in vivo infiltration Luminex assay Macrophage material maternal plasma Neonatal nucleic acid nucleic acid amplification objective Patient patients persistence Placenta placental pregnant patient pregnant women Protein recent recovered patient Remnant residual response Result RNA SARS‐CoV‐2 SARS‐CoV‐2 protein SARS‐CoV‐2 virus SARS‐CoV‐2 shown significantly specimen staining Symptom tissue tissues umbilical virus [DOI] 10.1111/cpr.13091 PMC 바로가기 [Article Type] Original Article
Biomaterials and Oxygen Join Forces to Shape the Immune Response and Boost COVID‐19 Vaccines생체 재료 및 산소 결합 힘을 결합하여 면역 반응을 형성하고 Covid -19 백신을 향상시킵니다.Research Article Published on 2021-07-202022-08-31 Journal: Advanced Science [Category] SARS, 치료제, [키워드] activate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive immune system antibody Antibody titer Antibody titers antigens approach Arm binding biomaterial boost coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 CpG Critical demonstrated Diseases dose effective effective vaccine Effective vaccines Effectiveness Emerging infectious diseases Engineering force generate GM‐CSF Health Health crisis immune response immune stimulation immunization immunized immunogenicity immunological immunomodulatory immunostimulation Infectious diseases injectable cryogel lack mice Neutralizing antibodies neutralizing antibody nucleocapsid offer overcome oxygen platform preclinical studies protective antibodies Protein Protein subunit vaccines RBD receptor‐binding domain reported required respiratory response resulting robust SARS‐CoV‐2 SARS‐CoV‐2 protein second dose severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccine shape Subunit vaccine subunit vaccines sustained Th1 Th2 Vaccine virus [DOI] 10.1002/advs.202100316 PMC 바로가기 [Article Type] Research Article
Gold Metallodrugs to Target Coronavirus Proteins: Inhibitory Effects on the Spike‐ACE2 Interaction and on PLpro Protease Activity by Auranofin and Gold Organometallics **코로나바이러스 단백질을 표적으로 하는 금 금속약물: Auranofin 및 금 유기금속에 의한 Spike-ACE2 상호작용 및 PLpro 프로테아제 활성에 대한 억제 효과 **Communication Published on 2020-10-192022-09-10 Journal: Chemistry (Weinheim an Der Bergstrasse, Germany) [Category] SARS, 치료제, [키워드] ACE2 activity acute respiratory syndrome angiotensin angiotensin converting enzyme anticancer antirheumatic antiviral drugs auranofin complexes coronavirus correlated drug target Effect effective inhibitor enzyme evaluated example FIVE gold gold complexes host receptor inhibitor inhibitors inhibitory effect Inhibitory effects Interaction interfere lead metallodrugs pilot study PLPro protease reported respiratory SARS-CoV-2 SARS‐CoV‐1 SARS‐CoV‐2 SARS‐CoV‐2 protein selected Spike protein target targets Viral viral entry process viral replication Zinc zinc ion zinc ions [DOI] 10.1002/chem.202004112 PMC 바로가기 [Article Type] Communication