Human-Immune-System (HIS) humanized mouse model (DRAGA: HLA-A2.HLA-DR4.Rag1KO.IL-2RγcKO.NOD) for COVID-19COVID-19에 대한 인간 면역 시스템(HIS) 인간화 마우스 모델(DRAGA: HLA-A2.HLA-DR4.Rag1KO.IL-2RγcKO.NOD)Article Published on 2022-11-302022-09-11 Journal: Human vaccines & immunotherapeutics [Category] SARS, 유전자 메커니즘, [키워드] Anti-viral B cell Blood candidate vaccine CD4 CD8 Cell clinical condition Cord blood COVID-19 COVID-19 research cytotoxic activity DRAGA mice Efficacy epithelial Express expressing functional granzyme B Hematopoietic stem cell Human human ACE2 receptor human antibodies Human immune system human lung-resident CD8 T cells humanized humanized mice IgG antibody immune immunopathological in vivo infused intra-alveolar lung lung immunopathology lung immunopathology. Lungs lymphocyte mechanism mice microthrombi mounted perforin promote Proteins replicating virus response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral secreted surrogate switching System T cell T cells Therapeutics unique upper respiratory airway Viral proteins [DOI] 10.1080/21645515.2022.2048622 PMC 바로가기 [Article Type] Article
Identification of mutations in SARS-CoV-2 PCR primer regionsArticle Published on 2022-11-042022-11-15 Journal: Scientific Reports [Category] SARS, 변종, 치료기술, 치료제, [키워드] Accuracy Analysis anticipated approach dataset diagnostic Efficiency genomic variation gold standard identification Mutation Neutral omicron overlapping PCR PCR efficiency primer primer set primer sets Region RT-PCR Sample SARS-CoV-2 SARS-CoV-2 PCR SARS-CoV-2 viral strain susceptible target region the SARS-CoV-2 genome variant Variation [DOI] 10.1038/s41598-022-21953-3 PMC 바로가기
Characteristics and Outcomes of Critically Ill Children With Multisystem Inflammatory SyndromeArticle Published on 2022-11-012022-11-16 Journal: Pediatric critical care medicine : a journal of th [Category] SARS, 변종, [키워드] acute respiratory syndrome B.1.1.7 Care children children with MIS-C cohort study coronavirus Critical D614G deaths decrease driving Frequency hospital Ill in viral Inflammatory interquartile range IQR LOS measurement mechanical ventilation median MIS-C Mortality outcome outcomes pediatric predominant Prevalence SARS-CoV-2 SARS-CoV-2 viral significant decrease strain study period syndrome System the disease the median viral strain [DOI] 10.1097/PCC.0000000000003054 PMC 바로가기
A Randomized Phase 2/3 Study of Ensitrelvir, a Novel Oral SARS-CoV-2 3C-Like Protease Inhibitor, in Japanese Patients with Mild-to-Moderate COVID-19 or Asymptomatic SARS-CoV-2 Infection: Results of the Phase 2a PartArticle Published on 2022-10-182022-11-15 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome All adverse event Asymptomatic baseline clinical coronavirus coronavirus disease COVID-19 Culture demonstrated double-blind Efficacy and safety ensitrelvir fumaric acid greater group groups intention-to-treat population Japan Japanese log median time Mild Mild-to-moderate moderate multicenter novel oral Part Patient phase phase 2/3 Placebo positive Primary outcome proof-of-concept study protease Protease inhibitor Randomized receive reduced registry Result S-217622 SARS-CoV-2 SARS-CoV-2 3C-like protease inhibitor SARS-CoV-2 clearance SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 viral the SARS-CoV-2 tissue Treatment viral clearance Viral RNA viral titer viral titer. [DOI] 10.1128/aac.00697-22 PMC 바로가기
Development of a high-sensitivity and short-duration fluorescence in situ hybridization method for viral mRNA detection in HEK 293T cellsArticle Published on 2022-10-042022-11-15 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acute respiratory syndrome addition antibody Antigen applied approach Blood caused Cell Cell culture cells Concentration contagious coronavirus Coronavirus disease 2019 COVID-19 development Diagnosis disease DNA virus effective false-negative False-positive results faster Fluorescence in situ hybridization gold standard HEK 293T HEK 293T cell hepatitis A virus HPV Human immunodeficiency virus human papillomavirus IgM and IgG IMPROVE influenza viruses limitation MERS-CoV Middle East Monkeypox mRNA patients plasmids probe Protein public health reduced respiratory syndrome coronavirus RNA RNA virus RT-PCR SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 viral Sensitivity and specificity significantly spike Surveillance tissue Treatment virus was increased yielding [DOI] 10.3389/fcimb.2022.960938 PMC 바로가기
Evaluation of ECLIA antigen detection tests as screening methods for COVID-19 in comparison with molecular analysisArticle Published on 2022-10-012022-11-15 Journal: Irish Journal of Medical Science [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] Antigen antigen detection antigen test approach assumed COVID-19 cycle threshold diagnosis of COVID-19 Diagnostic methodology Elecsy electrochemiluminescence immunoassay evaluate Germany gold standard molecular analysis Patient positive processed Roche Diagnostics rRT-PCR RT-qPCR SARS CoV SARS-CoV-2 SARS-CoV-2 viral screening method selected sensitivity Sensitivity and specificity Support Swab viral loads [DOI] 10.1007/s11845-021-02863-1 PMC 바로가기
Virtual screening and molecular dynamics simulation for identification of natural antiviral agents targeting SARS-CoV-2 NSP10Short communication Published on 2022-10-012022-10-05 Journal: Biochemical and Biophysical Research Communication [Category] COVID19(2023년), SARS, 치료제, [키워드] Analysis Antiviral agents binding binding energy calculated Candidates complexes Compound COVID-19 docking enzymatic activity global pandemic inhibitor Interaction molecular dynamics Molecular dynamics simulation natural antiviral New nsp10 Protein RNA replication SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 viral selected stimulate suggested Vaccine Vaccine development Variation Virtual screening was performed ZINC database [DOI] 10.1016/j.bbrc.2022.08.029 [Article Type] Short communication
Sensitivity to Vaccines, Therapeutic Antibodies, and Viral Entry Inhibitors and Advances To Counter the SARS-CoV-2 Omicron VariantArticle Published on 2022-09-212022-11-15 Journal: Clinical microbiology reviews [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, 치료제, [키워드] acute respiratory syndrome advance antibodies antibody-based therapies booster characterized Community coronavirus counter COVID-19 disease severity driving effective strategy Effectiveness entry inhibitors Entry mechanism enzyme evade faster fusion inhibitors fusion pathway highlighting immune Immune escape immune evasion Immunity immunotherapies Infection inhibitor inhibitors Innate mitigate monoclonal motif mutated natural infection omicron pan-CoV vaccines Perspective raising resistance resulting SARS-CoV-2 SARS-CoV-2 Omicron SARS-CoV-2 variant SARS-CoV-2 viral Spread T cell T cell response the SARS-CoV-2 the spike protein Transmissibility Transmission Vaccine vaccine-induced antibody Vaccines variant variants virus [DOI] 10.1128/cmr.00014-22 PMC 바로가기
SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 proteinArticle Published on 2022-09-122022-11-15 Journal: PLoS Pathogens [Category] SARS, 치료제, [키워드] activities antiviral response binding catalytic domain Cell cellular metabolism complexes conserved Critical enzyme exhibit experiments expressed form group inhibitor Innate immunity interact Interaction investigated knock-out lysine marker MAVS mounted non-structural protein Protein reduced residues SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral SIRT5 stable complex therapeutic interventions Treatment viral replication [DOI] 10.1371/journal.ppat.1010811 PMC 바로가기
Identification of Drug Combination Therapies for SARS-CoV-2: A Molecular Dynamics Simulations ApproachArticle Published on 2022-09-092022-11-15 Journal: Drug design, development and therapy [Category] SARS, 신약개발, 치료제, [키워드] 3CL antiviral activity Antiviral treatment approved approved drug binding binding site carried caused Compound compounds conformational change coronavirus COVID-19 drug drug combination drug combinations Drug repurposing drug synergy Dynamics effective Efficacy enzyme Favipiravir identification in silico in vitro in vitro assays Infectious disease inhibitor inhibitory effect Ligand ligand docking M pro molecular Molecular dynamics simulation molecular dynamics simulations multiple binding sites. pandemic predicted protease Protein target Proteins provide reduced SARS-CoV-2 SARS-CoV-2 viral screened Simulation suggested synergism synergistic Toxicity Treatment treatments for COVID-19 virus [DOI] 10.2147/DDDT.S366423 PMC 바로가기