Computational Selectivity Assessment of Protease Inhibitors against SARS-CoV-2SARS-CoV-2에 대한 프로테아제 억제제의 컴퓨터 선택성 평가Article Published on 2021-02-192022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 assessment attrition binding caspase caspase-3 cathepsin chymase Compound conducted coronavirus eight factor Xa Health high risk inhibit inhibitors inhibitors of SARS-CoV-2 M pro molecular molecular docking molecular dynamics molecular target pandemic protease Proteases protocol reported researcher respiratory SARS SARS-CoV M SARS-CoV-2 screened selected selectivity severe acute respiratory syndrome Coronavirus structure-based design target targets thrombin Toxicity UCHL1 urgency Viral viral replication [DOI] 10.3390/ijms22042065 PMC 바로가기 [Article Type] Article
Biochemical screening for SARS-CoV-2 main protease inhibitorsSARS-CoV-2 주요 프로테아제 억제제에 대한 생화학적 스크리닝Research Article Published on 2020-10-062022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] Acetate antiviral drug Benzophenone biochemical Compound Corona cysteine cysteine protease derivative drugs Evan Evans blue expressed fluorescent host cell host cells identify inhibitor inhibitors inhibitors of SARS-CoV-2 lead M pro non-structural proteins pandemic performed phenylmercuric acetate polymerases polyproteins precursor protease Proteases replicate respiratory SARS-CoV M SARS-CoV-2 SARS-CoV-2 main protease Severe acute respiratory syndrome Severe Acute Respiratory Syndrome Corona Virus sulfonic acid target thimerosal virus was used [DOI] 10.1371/journal.pone.0240079 PMC 바로가기 [Article Type] Research Article
Understanding Selenium and Glutathione as Antiviral Factors in COVID-19: Does the Viral M pro Protease Target Host Selenoproteins and Glutathione Synthesis?Nutrition Published on 2020-09-022022-10-31 Journal: Frontiers in Nutrition [Category] COVID-19, [키워드] activate Algorithm antioxidant catalytically active cleavage site Clinical outcome component contribute coronavirus correlation COVID-19 cysteine protease Cytokine storm cytosolic deficiency DNA Effect exacerbated expected Factor glutathione Glutathione peroxidase glutathione peroxidase 1 GPx GPX1 inactive Inflammation inhibit knockdown M pro mechanism mutant NF-κB NF-κB activation oxidative stress precursors pro-inflammatory cytokines protease proteolytic rate-limiting enzyme reactive oxygen specy resulting ribonucleotide RNA synthesis SARS-CoV M SARS-CoV-2 Selenium SELENOF selenoprotein sequence shown target thioredoxin reductase transfected cells turn understanding virion production wild-type [DOI] 10.3389/fnut.2020.00143 PMC 바로가기 [Article Type] Nutrition
Structure-Based Drug Design of an Inhibitor of the SARS-CoV-2 (COVID-19) Main Protease Using Free Software: A Tutorial for Students and Scientistspreprint Published on 2020-08-122022-10-31 Journal: ChemRxiv [Category] COVID-19, [키워드] AutoDock coronavirus COVID-19 disseminate drug drug candidate drug design experimental validation Free help homologous information inhibitor Interaction M pro modify molecular docking pandemic Pandemics peptide Peptide inhibitor protease provide SARS Coronavirus SARS-CoV SARS-CoV M SARS-CoV-2 scientist structure-based design structures student supplementary material the SARS-CoV-2 tutorial UCSF Chimera X-ray X-ray crystallographic structure [DOI] 10.26434/chemrxiv.12791954 PMC 바로가기 [Article Type] preprint
New Tetromycin Derivatives with Anti-Trypanosomal and Protease Inhibitory Activities †Article Published on 2011-09-262022-10-30 Journal: Marine Drugs [Category] Coronavirus, [키워드] activity Analysis anti-trypanosomal antiparasitic assigned Axinella cathepsin B cathepsin L Compound cysteine protease derivative derivatives Leishmania major marine sponge New NMR spectroscopy protease protease inhibition SARS-CoV M Streptomyce Streptomyces axinellae Structure tested tetromycin Trypanosoma [DOI] 10.3390/md9101682 PMC 바로가기 [Article Type] Article
Small Interfering RNA Effectively Inhibits the Expression of SARS Coronavirus Membrane Gene at Two Novel Targeting SitesArticle Published on 2010-10-182022-10-30 Journal: Molecules [Category] Coronavirus, [키워드] analyzed blocked conserved coronavirus Critical demonstrated downregulate downregulated Effect eGFP expression Gene Expression information interferon isolate isolates M gene membrane Membrane gene novel nucleotide nucleotide substitution occur post-transcriptionally Protein qRT-PCR Quantitative Region RNA RNA molecule RT-PCR SARS-CoV SARS-CoV infection SARS-CoV M semi-quantitative sequence significantly siRNA Site Small interfering RNA targeting tested upregulation viral genome viral infection [DOI] 10.3390/molecules15107197 PMC 바로가기 [Article Type] Article
Studies on membrane topology, N-glycosylation and functionality of SARS-CoV membrane proteinResearch Published on 2009-06-182022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] acute respiratory syndrome Amino acid Analysis biochemical C-terminal Cell culture conserved coronavirus Coronaviruses ectodomain endodomain ERGIC expressing found functional glycosylated Golgi complex immunofluorescence immunogenic Interaction M protein membrane membrane protein N-glycosylation N-glycosylation site N-terminal recruitment SARS-CoV SARS-CoV M Surface glycoprotein Topology transmembrane transmembrane domain Viral particles viral spike protein virion virus [DOI] 10.1186/1743-422X-6-79 PMC 바로가기 [Article Type] Research