Potential of conserved antigenic sites in development of universal SARS-like coronavirus vaccinesArticle Published on 2022-09-202022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] Affinity maturation antibodies antibody antigenic antigenic site antigenic sites conserved conserved antigenic sites convalescent convalescent COVID-19 patients convalescent individual COVID-19 cross-neutralizing cross-neutralizing antibodies functional humoral immune response IMPROVE induce neutralizing antibody pandemic Potential promote provide RBD resulting risk SARS-CoV SARS-CoV-2 SARS-CoV-2 variant SARS-like coronavirus SARS-like coronavirus vaccine SARS-like coronavirus vaccines unique Universal vaccine Vaccine Vaccine design variants of concern zoonotic [DOI] 10.3389/fimmu.2022.952650 PMC 바로가기
Targeted isolation of diverse human protective broadly neutralizing antibodies against SARS-like viruses Research Published on 2022-06-022022-10-05 Journal: Nature Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome antibody binding breadth conserved coronavirus coronavirus vaccine development Donor effective Efficacy epitope exhibited Health Human in vivo Isolation mitigate molecular basis Neutralizing neutralizing antibody omicron Prophylactic Prophylaxis Protective RBD sarbecovirus Sarbecoviruses SARS-CoV-2 SARS-like coronavirus SARS-like virus the receptor-binding domain therapeutic threat Vaccines variant variants of concern VOCs [DOI] 10.1038/s41590-022-01222-1 [Article Type] Research
Present and future distribution of bat hosts of sarbecoviruses: implications for conservation and public healthArticle Published on 2022-05-252023-07-09 Journal: Proceedings of the Royal Society B: Biological Sci [Category] COVID19(2023년), [키워드] Climate change Diversity ecological niche models Forecasting SARS-like coronavirus [DOI] 10.1098/rspb.2022.0397 PMC 바로가기
Isothermal gene amplification coupled MALDI-TOF MS for SARS-CoV-2 detectionSARS-CoV-2 검출을 위한 등온 유전자 증폭 결합 MALDI-TOF MSArticle Published on 2022-05-152022-09-11 Journal: Talanta [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplification Analysis coronavirus COVID-19 current demonstrated detect early diagnosis effective false-negative false-negative results Frame Gene detection infected individual infected individuals isothermal lack MALDI-TOF MS MERS MERS-CoV Mutation nucleocapsid Open reading frame other coronaviruses pandemic pseudovirus risk Rolling Rolling circle amplification Saliva SARS-CoV SARS-CoV-2 SARS-CoV-2 detection SARS-like coronavirus severe acute respiratory syndrome Coronavirus specificity temperature Urine Vaccines Virus analysis. water [DOI] 10.1016/j.talanta.2022.123297 PMC 바로가기 [Article Type] Article
Circadian rhythm disruption in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Implications for the post-acute sequelae of COVID-19Research article Published on 2022-03-012022-10-05 Journal: Brain, Behavior, & Immunity - Health [Category] 바이오마커, [키워드] activity autonomic Biomarker Brain cause caused cells changes in characterized chronic fatigue syndrome circadian rhythm cognitive coronavirus COVID-19 COVID-19 pandemic cytokine Depression disorder disrupting dysfunction Evidence examined fatigue growth factor immune implication Inconclusive increasingly Infection Inflammatory response Insomnia Major methodological molecular myalgic encephalomyelitis Older organ systems outbreak over overlap pandemic PASC Perspective physiological problem problems progressed reported Research SARS-CoV2 SARS-like coronavirus Signaling Sleep Symptoms temperature therapeutic interventions transforming growth factor beta viral infections while [DOI] 10.1016/j.bbih.2022.100412 [Article Type] Research article
SARS-like Coronaviruses in Horseshoe Bats ( Rhinolophus spp.) in Russia, 2020Article Published on 2022-01-092022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] Rhinolophus acquisition bat bat SARS-like coronaviruses Bulgaria cave coronavirus described Evidence genetic diversity greater horseshoe horseshoe bats involved Kenya Lineage oral swab ORF3 ORF6 ORF7a ORF7b Phylogenetic positive Prevalence recombination event Region related virus RT-PCR Russia SARS-CoV SARS-CoV-2 SARS-CoV-like viruses SARS-like coronavirus structural protein viral metagenomics virus viruses Zoonotic viruses [DOI] 10.3390/v14010113 PMC 바로가기 [Article Type] Article
Infection and transmission of ancestral SARS-CoV-2 and its alpha variant in pregnant white-tailed deer임신한 흰꼬리사슴에서 조상 SARS-CoV-2 및 그 알파 변이체의 감염 및 전파Coronaviruses Published on 2021-12-212022-09-10 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] addition Alpha Alpha variant Alpha VOC B.1.1.7 B.1.1.7 isolate cervid circulating Co-infection competition Contact coronavirus deer demonstrated determine direct contact evidence of examined fetus Genome global pandemic Host human population human populations in silico in viral in vitro study indicated Infection intermediate hosts investigated Lineage nasal natural infection Next-generation sequencing oral cavities outbreak Pregnancy pregnant recent reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 isolates SARS-like coronavirus Sequencing shown susceptibility susceptible tissue tissues Transmission transmission of SARS-CoV-2 variant variety Viral virus VoC was used white-tailed deer widespread [DOI] 10.1080/22221751.2021.2012528 PMC 바로가기 [Article Type] Coronaviruses
564. SARS-CoV-2 Ferritin Nanoparticle Vaccines Elicit Broad SARS Coronavirus ImmunogenicityPoster Abstracts Published on 2021-11-042022-10-29 Journal: Open Forum Infectious Diseases [Category] COVID-19, [키워드] analyzed antibody antigenic approach binding breadth clinical trial Combination domain elicit elicited Emergency use authorization global pandemic Heterologous High-dose highlight immune response immunization immunogen immunogenicity K18-ACE2 K18-hACE2 mice Multiple murine mutations N-terminal domain nanoparticle neutralization Neutralizing NTD observation pandemic platform prefusion pseudovirus RBD reported responses Result robust SARS-CoV RBD SARS-CoV-1 SARS-CoV-1 RBD SARS-CoV-1 virus SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 RBD SARS-CoV-2 variant SARS-CoV-2 virus SARS-CoV-2 virus variant SARS-like coronavirus sera spike the SARS-CoV-2 transfused transgenic mice Transgenic mouse Vaccine Vaccine design vaccine platform variant variants of concern virus were assessed zoonotic [DOI] 10.1093/ofid/ofab466.762 PMC 바로가기 [Article Type] Poster Abstracts
Mutants of human ACE2 differentially promote SARS-CoV and SARS-CoV-2 spike mediated infection인간 ACE2의 돌연변이는 SARS-CoV 및 SARS-CoV-2 스파이크 매개 감염을 차등적으로 촉진합니다Research Article Published on 2021-07-162022-09-10 Journal: PLoS Pathogens [Category] SARS, 변종, [키워드] abrogated abundance ACE2 ACE2 protein ACE2 sequence Affect allele bind binding biochemical Cell cell line cell surface cells change coding coronavirus coronavirus spike proteins correlated CoV spike proteins Cross-species transmission Cytopathic effect cytopathic effects determine Effect Efficiency engage events exomes expressed expression fraction Genetic genomic integration HEK 293T Human human ACE2 human Ace2 protein implication infect cells Infection inhibited Interaction Missense missense mutants Modification mutant mutants N501Y Non-linear relationship nucleotide overlapping parental promote Protein pseudotyped lentivirus pseudovirus entry pseudovirus infection Quantitative receptor protein reduced reducing reference sequence SARS-CoV SARS-CoV entry SARS-CoV-2 SARS-CoV-2 RBD binding SARS-CoV-2 replication SARS-CoV-2 spike SARS-CoV-2 spike proteins SARS-CoV-2 spike variants SARS-like coronavirus SARS-like coronaviruses sequence single nucleotide Spike protein Spike proteins susceptibility susceptibility to infection target cell target cells the cell the spike protein transgenic unique variant variants Viral viral spike virus viruses while zoonotic [DOI] 10.1371/journal.ppat.1009715 PMC 바로가기 [Article Type] Research Article
Piece of the puzzle: Remdesivir disassembles the multimeric SARS-CoV-2 RNA-dependent RNA polymerase complex퍼즐 조각: Remdesivir는 다량체 SARS-CoV-2 RNA 의존성 RNA 중합효소 복합체를 분해합니다Article Published on 2021-06-012022-09-11 Journal: Cell biochemistry and biophysics [Category] SARS, 치료제, [키워드] Accelerated molecular dynamics simulation adenosine ATP binding complex computational simulations contribute Detachment disrupt domain domains finding flexible followed by global mortality higher affinity hosts Human mechanism molecular molecular dynamics Molecular dynamics simulation non-structural proteins Nsp7 NSP8 nucleotide PALM Perturbation piece RdRP Remdesivir Replication replicative reported RNA RNA-dependent RNA polymerase SARS-CoV-2 SARS-like coronavirus significantly Spread structure-based design subunit the SARS-CoV-2 underlie Viral RNA virus [DOI] 10.1007/s12013-021-00977-y PMC 바로가기 [Article Type] Article