Humoral response and safety of the third booster dose of BNT162b2 mRNA COVID-19 vaccine in patients with multiple sclerosis treated with ocrelizumab or fingolimodArticle Published on 2022-12-012022-11-15 Journal: Journal of Neurology [Category] COVID19(2023년), SARS, 진단, [키워드] binding antibody unit BNT162b2 mRNA BNT162b2 mRNA vaccine booster dose collected Control COVID-19 COVID-19 vaccine dose expressed fingolimod HCs humoral Humoral response IgG IgG antibody IgG level Laboratory mRNA mRNA vaccine Multiple multiple sclerosis Ocrelizumab of BNT162b2 Patient positive predict quantified reported SARS-CoV-2 sclerosis serum sample severe adverse event socio-demographic threshold Tolerability treated Trimeric spike protein Vaccine vaccine dose variable [DOI] 10.1007/s00415-022-11296-4 PMC 바로가기
Humoral response to COVID-19 vaccination in MS patients on disease modifying therapy: Immune profiles and clinical outcomesArticle Published on 2022-11-012022-10-05 Journal: Multiple sclerosis and related disorders [Category] COVID19(2023년), SARS, 바이오마커, 진단, 치료기술, [키워드] administration age anti-CD20 anti-CD20 therapy Anti-SARS-CoV-2 S antibody Antibody Response Antibody titer appear B-cell CD20 cell count Clinical outcome Cohort collected Comprehensive COVID-19 COVID-19 infection COVID-19 vaccination death demographic demonstrated diagnosed with COVID-19 died disease Disease modifying therapy effective enrolled female FIVE Follow-up healthy control healthy controls humoral Humoral immunity Humoral response ICU care Immune profile immunoglobulins incidence increased risk investigation less longitudinal Lymphocyte count Multiple multiple sclerosis outcome Patient preventing infection profile reduced required Responder response to vaccination Result retrospective SARS-CoV-2 spike sclerosis serum severe disease significantly lower single-center study therapy Treatment vaccinated against COVID-19 vaccination Vaccine [DOI] 10.1016/j.msard.2022.104079 [Article Type] Article
Clinical onset of CNS demyelinating disease after COVID-19 vaccination: denovo disease?Article Published on 2022-11-012022-11-15 Journal: Multiple sclerosis and related disorders [Category] SARS, 진단, [키워드] absence age association case sery cell counts cerebrospinal fluid Characteristics clinical Clinical characteristics CNS Cohort comparable COVID-19 CSF demyelinating Demyelinating disease disease Evidence Follow-up glycoprotein indicate initial lesion magnetic resonance imaging MRI Multiple multiple sclerosis Multiple sclerosis (MS) Myelin Myelin oligodendrocyte glycoprotein antibody-related disease (MOGAD) Neuroinflammation occurred Optical coherence tomography parameter Patient reported SARS-CoV-2 SARS-CoV-2- (COVID-19) vaccination. sclerosis vaccination [DOI] 10.1016/j.msard.2022.104175 PMC 바로가기
Systems Bioinformatics Reveals Possible Relationship between COVID-19 and the Development of Neurological Diseases and Neuropsychiatric DisordersArticle Published on 2022-10-162022-11-16 Journal: Viruses [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Acidic acute respiratory syndrome Analysis app Autoimmunity bioinformatics biological processe Combination contribute coronavirus COVID-19 development disease disease-associated disorder disorders dysregulation epitope Epitopes genetic risk factor GFAp Host identify incidence include increased risk indicated Infection linear MAPT microtubule-associated protein modulated molecular molecular mimicry motif Multiple Myasthenia network biology neurodegenerative Neurodegenerative diseases neurological Neurological disease Neurological diseases Neurological disorder Neuropsychiatric neuropsychiatric disorders PPI precursor Protein protein-protein interaction Proteins receptors recognize relationship SARS-CoV-2 SARS-CoV-2 epitope SARS-COV-2 infection sclerosis sequence similarity System systems bioinformatics. [DOI] 10.3390/v14102270 PMC 바로가기
Timing of SARS-CoV-2 Vaccination Matters in People With Multiple Sclerosis on Pulsed Anti-CD20 TreatmentArticle Published on 2022-10-122022-11-15 Journal: Neurology® neuroimmunology & neuroinflammation [Category] COVID19(2023년), SARS, 바이오마커, 변종, 진단, [키워드] acute respiratory syndrome Analysis analyzed anti-SARS-CoV-2 antibody Antibody Response association Blood CD19 CD3 CD4 CD8 CD8 T cell CD8 T-cell response cellular center clinical decision Cohort collected conducted coronavirus coronavirus disease correlated cross-sectional Defense evaluate Germany humoral immune response Humoral response immune response Immunoglobulin Infection interferon-γ interval lymphocyte counts matter Multiple multiple sclerosis Patient peptide pools receiving regulated response responses Sample SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 vaccination sclerosis significantly increased Spike protein Status post subpopulation T cell T-cell the timing Treatment vaccination vaccination response Vaccination strategy variants of concern were measured [DOI] 10.1212/NXI.0000000000200031 PMC 바로가기
SARS-CoV-2 vaccination in patients with multiple sclerosis in Germany and the United Kingdom: Gender-specific results from a longitudinal observational studyArticle Published on 2022-09-022022-10-06 Journal: Lancet Reg Health Eur [Category] 진단, [키워드] Adverse adverse events analysed AZD1222 Biogen Bristol Clinical data courses COVID-19 Deterioration effective fatigue Frequency Gender Germany headache Health impairment injection long-lasting longitudinal men Merck Serono Multiple multiple sclerosis Mylan Novartis occurred offer opposite Pain participated Patient reaction real-world data registry reported resulting Roche Sanofi SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine sclerosis severe COVID-19 disease Society Sociodemographic stratified Symptoms Tolerability United Kingdom vaccination Vaccination reaction Vaccination reaction. Vaccine women worsened [DOI] 10.1016/j.lanepe.2022.100502 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection in multiple sclerosis patients: interaction with treatments, adjuvant therapies, and vaccines against COVID-19다발성 경화증 환자의 SARS-CoV-2 감염: COVID-19에 대한 치료법, 보조 요법 및 백신과의 상호 작용Review Published on 2022-09-012022-09-11 Journal: Journal of Neurology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] adjuvant adjuvant therapies Adjuvant treatments Affect Antibody titer B-cell causes consequence COVID COVID-19 detectable Disease-modifying therapies help immune response Immunity increased risk Infection Interaction long term Multiple multiple sclerosis neuro-COVID neurological Neurological symptom Neurological symptoms Neutralizing antibody titer Patient Probability raised risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pandemic sclerosis Therapies therapy treated Treatment Vaccine virus [DOI] 10.1007/s00415-022-11237-1 PMC 바로가기 [Article Type] Review
Immune response in ofatumumab treated multiple sclerosis patients after SARS-CoV-2 vaccinationArticle Published on 2022-08-312022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] alteration anti-CD20 anti-CD20 therapy antibody applied approach B cell caused CD4 Cellular immune response cellular immunity characterized Complete decrease Delta disorder dosage Effect elicit Frequency healthy controls humoral humoral immune response immune Immune cell immune cells immune response Immunosuppression implication information investigated mean treatment duration Multiple multiple sclerosis neutralization capacity Ofatumumab ofatumumab. omicron pandemic Patient preserved Regulatory T cell SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 variant sclerosis subcutaneously subpopulation sustained T cell T cell response T helper Th1 titer treated treated patient Treatment Tregs vaccination was impaired wild type [DOI] 10.3389/fimmu.2022.980526 PMC 바로가기
A multiparametric score for assessing the individual risk of severe Covid-19 among patients with Multiple SclerosisResearch article Published on 2022-07-012022-10-05 Journal: Multiple sclerosis and related disorders [Category] 유전자 메커니즘, [키워드] age analyses anti-CD20 treatment applied approach AUC Bayesian BMI calculate calculated can be used Characteristics Clinical practice coefficient country Course COVID-19 severity cut-off dataset defined disability disease EDSS equipment evaluate external validation form General population high-risk patient higher risk Hospitalization identify Infection Italy LASSO linear combination logistic regression model Male sex measure Methylprednisolone missing values Multiple multiple sclerosis multivariable multivariable logistic regression Older age Patient patients performed platform Predictive presence of comorbidities Prevent Probability required Result risk Risk assessment score risk factor ROC Curve scale sclerosis separated severity Sex social distancing South America status the patient training data training dataset Treatment Turkey variable [DOI] 10.1016/j.msard.2022.103909 [Article Type] Research article
SARS-CoV-2 infection in patients with neuroimmunological disorders in a tertiary referral centre from the north of Portugal포르투갈 북부의 3차 의뢰 센터에서 신경 면역 장애 환자의 SARS-CoV-2 감염Article Published on 2022-07-012022-09-11 Journal: Multiple sclerosis and related disorders [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] age Analysis anti-CD20 association Autoimmune encephalitis CD20 chronic chronic inflammatory demyelinating polyneuropathy clinical clinical recovery Comorbidities Comorbidity Course COVID-19 COVID-19 in patient COVID-19 severity Critical Critical disease demyelinating died disease disorder Evidence female form Hospitalized immunosuppressants increased risk IQR median Mild Most patient Most patients Multiple multiple sclerosis Myasthenia myasthenia gravis Neuroimmunology North Older outcome outpatient clinic Patient Polyneuropathy Portugal reported Retrospective analysis SARS-COV-2 infection sclerosis severe disease Severe infection significantly tertiary referral centre therapy were infected [DOI] 10.1016/j.msard.2022.103893 PMC 바로가기 [Article Type] Article