Phase II/III trial of hyperimmune anti-COVID-19 intravenous immunoglobulin (C-IVIG) therapy in severe COVID-19 patients: study protocol for a randomized controlled trialArticle Published on 2022-11-082022-11-16 Journal: Trials [Category] SARS, 변종, [키워드] adaptive anti-COVID-19 IVIG antivirals clinical evidence clinical trial collected convalescent convalescent plasma COVID-19 cumulative death Efficacy eligibility criteria evaluate Health hyperimmune immunization immunomodulators intravenous Intravenous immunoglobulin low dose monoclonal antibodies Neutralizing non-specific novel Novel coronavirus outcome Passive passive immunization Patient phase Pneumonia polyclonal polyclonal antibodies Pooled convalescent plasma Potential treatment Randomized Randomized controlled trial receive Recovered COVID-19 patients reported SARS CoV-2 SARS-CoV-2 sealed Secondary outcomes severe COVID-19 severe COVID-19 patient severe COVID-19 patients Standard of care Steroids Study protocol therapeutic option therapy treat Treatment Trial variant variants of concern virus virus particles World Health Organization [DOI] 10.1186/s13063-022-06860-2 PMC 바로가기
Outcomes of Convalescent Plasma with Defined High versus Lower Neutralizing Antibody Titers against SARS-CoV-2 among Hospitalized Patients: CoronaVirus Inactivating Plasma (CoVIP) StudyArticle Published on 2022-10-262022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 진단, [키워드] 95% CI 95% confidence interval acute respiratory syndrome addition adopted Adverse adverse event AEs amplification antibodies CCP Clinical outcome competing Concentration conducted convalescent convalescent plasma coronavirus COVID-19 death defined donors dose response Effectiveness eligible evaluate evaluated event Fisher Gray hazard ratio heterogeneity high-risk population hospital hospital discharge immunology Inconclusive Infection Lower Mortality NAb Neutralizing antibodies neutralizing antibody observational study occurred participant Patient positive primary clinical outcome randomized control trial receiving Registered Research Respiratory Support Result risk SAEs SARS-CoV-2 SARS-CoV-2 nucleic acid screened Secondary outcomes severe COVID-19 Standard of care Support Symptom therapeutic therapy time titer Treatment [DOI] 10.1128/mbio.01751-22 PMC 바로가기
Building Emotional Awareness and Mental Health (BEAM): study protocol for a phase III randomized controlled trial of the BEAM app-based program for mothers of children 18-36 monthsArticle Published on 2022-09-052022-10-05 Journal: Trials [Category] 임상, [키워드] Anxiety anxiety symptoms assessment Awareness build building children Cohort COVID-19 pandemic Depression Efficacy elevated emotion evaluate finding Follow-up Health IMPROVE improvement individual Intervention Maternal mental health mental health disorders mental illness mother occur pandemic Parenting pregnant Prevalence Primary outcome programming Psychoeducation Randomized Randomized controlled trial RCT RCT. recruited reducing repeated measure risk Secondary outcomes Stress Study protocol Support Symptom Symptoms symptoms of depression Tau treatment as usual treatment group Trial Two-arm used to evaluate [DOI] 10.1186/s13063-022-06512-5 PMC 바로가기 [Article Type] Article
A systematic review and meta-analysis of immune response against first and second doses of SARS-CoV-2 vaccines in adult patients with hematological malignancies혈액암이 있는 성인 환자의 SARS-CoV-2 백신 1차 및 2차 접종에 대한 면역 반응의 체계적인 검토 및 메타 분석Review Published on 2022-09-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] 95% confidence interval 95%CI affected affecting anti-CD20 therapy antibody Antibody detection Antibody Response article booster dose booster doses calculated Cancer patients chronic lymphocytic leukemia CLL Complete conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines develop Diagnosis disease doses evaluate first dose Google Google Scholar healthy subject healthy subjects Hematological malignancies Hematological malignancy higher risk highlight highlighting immune response Immunity immunization Immunocompromised immunogenicity immunosuppressive IMPROVE kinase inhibitors less leukemia lowest Lymphocytic leukemia lymphoma malignancy measure Meta-analysis mRNA mRNA-1273 Myeloma Patient Primary outcome response rate SARS-CoV-2 SARS-CoV-2 vaccine second dose secondary outcome Secondary outcomes seropositive Seropositivity severe coronavirus disease solid tumor solid tumors status subgroup subtype systematic review the disease the vaccine tumors tyrosine tyrosine kinase inhibitor tyrosine kinase inhibitors Vaccine vaccine dose vaccine's immunogenicity Web of Science [DOI] 10.1016/j.intimp.2022.109046 PMC 바로가기 [Article Type] Review
Early reduction of estimated Glomerular Filtration Rate (eGFR) predicts poor outcome in acutely ill hospitalized COVID-19 patients firstly admitted to medical regular wards (eGFR-COV19 study)Research article Published on 2022-09-012022-10-05 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 바이오마커, [키워드] Acute kidney injury Admission age Analysis analyzed ARDS association AUC Autopsy baseline value calculated Chronic kidney disease correlated COVID-19 creatinine diagnosed died discharge division Efficacy GFR glomerular filtration rate hospital Hospital admission hospital discharge hospitalized COVID-19 patient hospitalized patient ICU identify IL-6 IMV In-hospital death in-hospital mortality Infection intensive care internal Invasive mechanical ventilation KDIGO AKI kidney Kidney injury mechanical ventilation Medicine NIV non-invasive ventilation outcome Patient patients patients’ medical record predict Predictive Primary outcome Prognosis Rate reduction renal dysfunction renal function representing Result SARS-CoV-2 score Secondary outcomes Serum level significantly significantly lower statistical analysis symptomatic Symptoms tissue were assessed with COVID-19 [DOI] 10.1016/j.biopha.2022.113454 [Article Type] Research article
Gastrointestinal Manifestations in Hospitalized Children With Acute SARS-CoV-2 Infection and Multisystem Inflammatory Condition: An Analysis of the VIRUS COVID-19 RegistryObservational Study Published on 2022-09-012022-10-04 Journal: The Pediatric Infectious Disease Journal [Category] COVID19(2023년), SARS, 임상, [키워드] acute COVID-19 adjusted association children cohort study Comorbidity coronavirus disease COVID-19 COVID-19 illness Critical Critical illness defined died entire cohort Gastrointestinal GI symptom hospital Hospitalized illness incidence Inflammatory International liver manifestation median age MIS-C Mortality multicenter Multivariable models occurred Older outcome Patient patients performed primary outcome measure registry respiratory retrospective review SARS-CoV-2 secondary Secondary outcomes subpopulation syndrome Universal [DOI] 10.1097/INF.0000000000003589 PMC 바로가기 [Article Type] Observational Study
Screening and assessment for post-acute COVID-19 syndrome (PACS), guidance by personal pilots and support with individual digital trainings within intersectoral care: a study protocol of a randomized controlled trial급성 COVID-19 이후 증후군(PACS)에 대한 선별 및 평가, 개인 파일럿의 지도 및 부문 간 치료 내 개별 디지털 교육 지원: 무작위 대조 시험의 연구 프로토콜Article Published on 2022-08-152022-09-11 Journal: BMC Infectious Diseases [Category] SARS, 임상, [키워드] active control group activities activity applicability assigned both group both groups can be used Care chatbot comparability COVID-19 COVID-19 infection Cross-sectoral care Diagnosis Digital Digital therapy offers empowerment Endpoint evaluate evaluated example facilitate feasibility Guidance help helping Identifier IMPROVE Interdisciplinary diagnostic International Intervention intervention group long-COVID Low-threshold screening Medical rehabilitation outcome participant Participants Patient physiological platform Post-acute COVID-19 syndrome Post-COVID primary endpoints propensity score matching Psychological Randomized controlled trial Randomly receive recruited reduce reduction Registration Research return screened Screening secondary Secondary outcomes Study protocol Support supported Symptom Symptom assessment Symptoms syndrome therapy Treatment Trial registration [DOI] 10.1186/s12879-022-07584-z PMC 바로가기 [Article Type] Article
COCOS trial: CO rticosteroids for CO VID-19-induced loss of S mell-protocol for a single-centred, double-blind, randomised, placebo-controlled trialCOCOS 시험: 단일 중심, 이중 맹검, 무작위, 위약 대조 시험을 위한 CO VID-19 유발 S mell-protocol 손실에 대한 CO rticosteroidsArticle Published on 2022-08-102022-09-11 Journal: BMJ Open [Category] SARS, 임상, [키워드] addition Anosmia approved center Corticosteroids COVID-19 COVID-19 diagnosis determine disorder disorders double-blind early phase Efficacy Ethics gustatory function High-dose Hyposmia hypothesised IMPROVE include Inclusion induce Infectious diseases Inflammation institutional review board local inflammatory response Loss of Smell matching placebo Most patient Most patients nasal olfactory olfactory function olfactory nerve otolaryngology outcome pathway Patient peer-reviewed persist Placebo placebo-controlled trial positive Prednisolone Primary outcome Quality of life Questionnaires randomised receive reduce registration number Research protocol secondary Secondary outcomes stick Symptoms Treatment Trial university [DOI] 10.1136/bmjopen-2021-060416 PMC 바로가기 [Article Type] Article
Identifying Promising Themes for Adolescent Vaping Warnings: A National ExperimentRandomized Controlled Trial Published on 2022-08-062022-10-04 Journal: Nicotine & tobacco research : official journal of [Category] 임상, [키워드] Adolescent Affect anticipated COVID-19 Effect effective Effectiveness elicited expand FDA FIVE greater Health Health messaging identify identifying interactions lung National outcome participant PME Primary outcome Probability Randomized recruited secondary Secondary outcomes The United States [DOI] 10.1093/ntr/ntac093 PMC 바로가기 [Article Type] Randomized Controlled Trial
Comparison of Severe Maternal Morbidities Associated With Delivery During Periods of Circulation of Specific SARS-CoV-2 Variants특정 SARS-CoV-2 변이체의 순환 기간 동안 분만과 관련된 심각한 산모 이환율의 비교Multicenter Study Published on 2022-08-012022-09-11 Journal: JAMA Network Open [Category] SARS, 변종, [키워드] age Alpha Alpha variant amplification analyzed association B.1.1.7 B.1.617.2 cause center characterized clinical variable cohort study complications Control COVID-19 defined delivery Delta delta variant demographic and clinical variables disease control dominant evaluate event events Evidence evidence of example health system highest Hospitalization individual Infection IQR Maternal median morbidity multicenter nucleic acid nucleic acid amplification test Odds ratio omicron outcome outcomes over pandemic Patient patients with SARS-CoV-2 Period predominant pregnant patient pregnant patients prevention preventive measures Primary outcome reflected Respiratory complications retrospective cohort study risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleic acid secondary Secondary outcomes severity of COVID-19 significantly higher Specific Strains test result the SARS-CoV-2 type strain Variation viral strain viral strains was increased while wild-type strain [DOI] 10.1001/jamanetworkopen.2022.26436 PMC 바로가기 [Article Type] Multicenter Study