CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infectionCSF 접촉 뉴런은 폐렴구균에 반응하고 중추 신경계 감염 동안 숙주 생존을 촉진합니다.Article Published on 2023-03-132024-08-24 Journal: Current Biology [Category] 폐렴구균 감염증, [키워드] bacterial meningitis bitter compounds Central nervous system infection cerebrospinal fluid Cytokines cytolysins host defense Innate immunity Interoception neurosecretion pathogen detection peptides sensory neurons taste receptors.
Direct neuronal infection of SARS-CoV-2 reveals cellular and molecular pathology of chemosensory impairment of COVID-19 patientsSARS-CoV-2의 직접적인 신경 감염은 COVID-19 환자의 화학 감각 장애의 세포 및 분자 병리를 드러냅니다Coronaviruses Published on 2022-01-272022-09-12 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 진단, [키워드] abnormality absence ACE2 acute respiratory syndrome Cell cellular and molecular chemosensory chemosensory impairment clinical manifestations coronavirus COVID-19 COVID-19 pathogenesis COVID-19 patient Critical Determining develop Direct disease dysfunction early stage embryonic exhibited expressed function Gustatory hESC-derived peripheral neurons Human impairment in vitro infect infected with SARS-CoV-2 Infection infection modelling mechanism molecular molecular feature neurological abnormality Neuron neuronal infection olfactory organs pandemic coronavirus Pathogenesis pathology patients with COVID-19 peripheral responsible reveal SARS-CoV-2 sensory neuron sensory neurons Symptom therapeutic target viral entry viral infection was used [DOI] 10.1080/22221751.2021.2024095 PMC 바로가기 [Article Type] Coronaviruses
Innate Receptors Expression by Lung Nociceptors: Impact on COVID-19 and Aging폐 통각 수용체에 의한 타고난 수용체 발현: COVID-19 및 노화에 미치는 영향Review Published on 2021-12-162022-09-11 Journal: Frontiers in Immunology [Category] SARS, 치료기술, 치료제, [키워드] Activation aging aging process airway airways competent contribute COVID-19 COVID-19 pandemic described disorder disorders disturbance dysfunction Evidence expression functional Immunity immunological Immunological response immunological responses Impact individual inflammaging Innate innate receptors local immune response lung Lung function Lungs mechanism neuroimmune crosstalk neurological New nociceptors organ outcomes Particle Particles pathogen pathogen invasion Pathogens physiological Prevent receptor receptors reservoir reservoirs respiratory respiratory tract responsible SARS-CoV-2 SARS-COV-2 infection sensory nerve sensory neuron sensory neurons shown Spread target threat Threats tissue injury Trigger Viral [DOI] 10.3389/fimmu.2021.785355 PMC 바로가기 [Article Type] Review
Dysautonomia and Implications for Anosmia in Long COVID-19 DiseaseReview Published on 2021-11-252022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] ACE2 ACE2 antibody activity aggregate Anosmia association autonomic Brain cascade cerebrospinal fluid characterized circulation coagulation cascade component COVID-19 COVID-19 diagnosis COVID-19 neurological symptoms COVID-19 patient COVID-19 patients described Dysautonomia Effect Endothelial dysfunction expression facilitate fatigue immune activation increase in involved Long Long COVID-19 multiple organ dysfunction nervous system Neuroinflammation neurologic neurological neuronal neurotropism olfactory Olfactory epithelium Patient Peripheral blood persistent predominant recent reported SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 neurotropism sensory neurons shown subsequent Symptom Symptoms TMPRSS2 Travel triggering vessel [DOI] 10.3390/jcm10235514 PMC 바로가기 [Article Type] Review
COVID-19-related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamstersCOVID-19 관련 후각상실증은 인간 후각 상피의 바이러스 지속성 및 염증 및 햄스터의 뇌 감염과 관련이 있습니다Research Article Published on 2021-05-032022-09-12 Journal: Science Translational Medicine [Category] MERS, SARS, 진단, [키워드] Ageusia Anosmia Brain infection cell types cells cellular conducted COVID-19 disease Evidence Factor hamster hamsters immune cells individuals with COVID-19 infected cells Infection Inflammation Inflammatory involved local inflammation Loss of Smell lung management mildly symptomatic patients molecular mucosa Neurological disorder Neurological disorders olfactory olfactory bulb Olfactory epithelium olfactory neuroepithelium Pathogenesis pathophysiology Patient patients with COVID-19 persist persistence presenting relapsing remained SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2-infected cells SARS-CoV2 infection sensory neurons Seven Support symptoms of COVID-19 taste dysfunction transcript Vascular viral persistence virus [DOI] 10.1126/scitranslmed.abf8396 PMC 바로가기 [Article Type] Research Article
Spinal neuron-glia-immune interaction in cross-organ sensitizationNeurogastroenterology and Motility Published on 2020-12-012024-09-04 Journal: American journal of physiology. Gastrointestinal and liver physiology [Category] 대상포진, [키워드] cross-organ sensitization intercell interaction Neuroinflammation sensory neurons visceral hypersensitivity [DOI] 10.1152/ajpgi.00323.2020 PMC 바로가기 [Article Type] Neurogastroenterology and Motility
Immediate activation of chemosensory neuron gene expression by bacterial metabolites is selectively induced by distinct cyclic GMP-dependent pathways in Caenorhabditis elegans박테리아 대사 산물에 의한 화학 감각 뉴런 유전자 발현의 즉각적인 활성화는 Caenorhabditis elegans에서 별개의 순환 GMP 의존 경로에 의해 선택적으로 유도됩니다Research Article Published on 2020-08-102022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate Activation addition animals Author avoidance bacterial metabolite Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans calcium canonical cGMP chemosensory cyclic GMP dependent on detect dissect dynamic elegan elegans engage expression external environment gene encoding Gene Expression highlighting Immediate induce intracellular signaling lead Ligand mechanism metabolite metabolites microbial modulate nervous system neuroendocrine Neuron neuronal neurons P . aeruginosa pair pathogen pathogenic pathogenic bacteria pathogenic bacterium pathway produced Protective Protein protein kinase Pseudomonas aeruginosa required response selective sensation sensory neuron sensory neurons Signal transduction Signaling signaling pathway subunit TGF-β Transcription transcriptional transcriptional response turn [DOI] 10.1371/journal.pgen.1008505 PMC 바로가기 [Article Type] Research Article
Therapeutic use of botulinum toxin in pain treatmentarticle Published on 2018-09-302024-09-02 Journal: Neuronal Signaling [Category] 대상포진, [키워드] axonal transport Botulinum toxin Central nervous system Neurotransmitters nociception sensory neurons [DOI] 10.1042/NS20180058 PMC 바로가기 [Article Type] article
Immunization Elicits Antigen-Specific Antibody Sequestration in Dorsal Root Ganglia Sensory NeuronsOriginal Research Published on 2018-04-162024-09-02 Journal: Frontiers in immunology [Category] 대상포진, [키워드] antibodies DRG Inflammation neural circuits sensory neurons [DOI] 10.3389/fimmu.2018.00638 PMC 바로가기 [Article Type] Original Research