Active Postlicensure Safety Surveillance for Recombinant Zoster Vaccine Using Electronic Health Record DataArticle Published on 2023-02-012023-05-31 Journal: American journal of epidemiology [Category] 두창, 수두, 홍역, [키워드] herpes zoster managed-care programs population surveillance sequential analysis shingles vaccine safety vaccines, combined zoster vaccine [DOI] 10.1093/aje/kwac170 PMC 바로가기
Agreement of treatment effects from observational studies and randomized controlled trials evaluating hydroxychloroquine, lopinavir-ritonavir, or dexamethasone for covid-19: meta-epidemiological study코로나19에 대한 히드록시클로로퀸, 로피나비르-리토나비르 또는 덱사메타손을 평가하는 관찰 연구 및 무작위 대조 시험의 치료 효과 일치: 메타 역학 연구Article Published on 2022-05-102022-09-11 Journal: The BMJ [Category] meta-analysis, 임상, [키워드] age agreement Analysis calculated Clinical data collected Comparisons complement conducted controlled trials COVID-19 treatment criteria data extraction database demographical and clinical data demographics Dexamethasone disease severity distribution Efficacy Epidemiological study evaluated Evidence Hydroxychloroquine identify independent Lopinavir Lopinavir-ritonavir Matched means Medicine meta-analysed meta-analyses Meta-analysis Network meta-analysis nine not significant observational studies observational study outcome outcomes overlapping Placebo PLOS proportion Randomized controlled trial RCT RCTs reported Ritonavir Safety sequential analysis Seven Sex significantly synthesis systematic review therapeutic intervention therapeutic interventions Treatment treatment effect treatment effects trial sequential analysis [DOI] 10.1136/bmj-2021-069400 PMC 바로가기 [Article Type] Article
Convalescent plasma for COVID-19: a meta-analysis, trial sequential analysis, and meta-regressionCOVID-19에 대한 회복기 혈장: 메타 분석, 시험 순차 분석 및 메타 회귀Meta-Analysis Published on 2021-12-012022-09-11 Journal: British journal of anaesthesia [Category] 임상, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adjusted administration angiotensin angiotensin-converting enzyme 2 antibodies association benefit clinical confidence interval convalescent convalescent plasma convalescent plasma treatment coronavirus COVID-19 Disease progression domain evaluate Host host cell host cells ICU admission Interaction mechanical ventilation medRxiv Meta-analysis meta-regression Mild disease Mortality Odds ratio outcome passive immunisation. Patient patients with COVID-19 performed plasma Prevent Primary outcome PROSPERO RCT RCTs receive receptor recruited reduction in Regression risk of death secondary Secondary outcomes sequential analysis severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specific antibodies systematic review titre Treatment Trial trial sequential analysis TSA viral entry viral spike with mild disease [DOI] 10.1016/j.bja.2021.07.033 PMC 바로가기 [Article Type] Meta-Analysis
Exact sequential test for clinical trials and post-market drug and vaccine safety surveillance with Poisson and binary dataPoisson 및 Binary Data를 사용한 임상 시험 및 시장 후 약물 및 백신 안전 감시에 대한 정확한 순차적 테스트Article Published on 2021-09-302022-08-31 Journal: Statistics in medicine [Category] MERS, SARS, 치료제, [키워드] adaptive adaptive design addition adverse event adverse events Alpha alpha spending Analysis calculation clinical trial continuous monitoring COVID-19 pandemic decision develop effort example expected group sequential. Hypothesis Hypothesis testing Influenza influenza vaccination Osteoporosis package performed Poisson R language Sample size sample sizes sequential analysis sequential test Signaling Statistical power Surveillance threshold Treatment vaccination Vaccine [DOI] 10.1002/sim.9094 PMC 바로가기 [Article Type] Article
Remdesivir for coronavirus disease 2019 (COVID-19): a systematic review with meta-analysis and trial sequential analysis of randomized controlled trials코로나바이러스 질병 2019(COVID-19)에 대한 렘데시비르: 무작위 대조 시험의 메타 분석 및 시험 순차적 분석을 통한 체계적인 검토Meta-Analysis Published on 2021-09-012022-09-11 Journal: Infectious diseases (London, England) [Category] Coronavirus, SARS, 임상, [키워드] 95% confidence interval addition all-cause mortality calculated conducted controlled trials coronavirus disease COVID-19 diarrhoea Efficacy Evidence evidence of FIVE heterogeneity high risk information Meta-analysis MOST nausea no evidence of occurred outcome outcomes Participants patients progression question random-effects model Randomized Randomized controlled trial Randomized controlled trials RCT RCTs reached Relative risk Remdesivir required risk Safety searched selected sequential analysis Support systematic review Treatment treatment of COVID-19 trial sequential analysis TSA viral burden vomiting [DOI] 10.1080/23744235.2021.1923799 PMC 바로가기 [Article Type] Meta-Analysis
Ivermectin for Prevention and Treatment of COVID-19 Infection: A Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical GuidelinesCOVID-19 감염 예방 및 치료를 위한 Ivermectin: 임상 지침을 제공하기 위한 체계적인 검토, 메타 분석 및 시험 순차 분석Meta-Analysis Published on 2021-06-212022-09-11 Journal: American journal of therapeutics [Category] SARS, 치료제, [키워드] 95% confidence interval adverse event Analysis anti-inflammatory properties antiparasitic Antiviral approach Area average average risk benefit certainty Chemoprophylaxis clinical Clinical course clinical trials conducted COVID-19 COVID-19 infection database death Deterioration Efficacy estimate Evidence evidence of guideline high risk Inclusion Ivermectin ivermectin treatment less mechanical ventilation Medicine meta-analyses Meta-analysis Mortality no difference outcome pandemic participant prevention Prophylaxis provided Randomized controlled trial reduce reduced reduced risk reducing mortality reductions in review Risk of bias risk ratio robust SARS-CoV-2 pandemic SARS-CoV-2 virus searched secondary secondary outcome Secondary outcomes sequential analysis severe adverse events severe disease suggested tested the SARS-CoV-2 the SARS-CoV-2 virus treatment trial treatment trials Trial trial sequential analyses trial sequential analysis [DOI] 10.1097/MJT.0000000000001402 PMC 바로가기 [Article Type] Meta-Analysis
Tocilizumab in COVID-19: a meta-analysis, trial sequential analysis, and meta-regression of randomized-controlled trials코로나19에서의 토실리주맙: 무작위 대조 시험의 메타 분석, 시험 순차 분석 및 메타 회귀Meta-Analysis Published on 2021-06-012022-09-11 Journal: Intensive care medicine [Category] Fulltext, SARS, 임상, 진단, [키워드] adjusted Admission benefit Beta Composite conducted control group COVID-19 defined did not reduce disease Evidence excluded hospitalized COVID-19 patients ICU ICU admission IL-6 IL-6 blockade IL-6 inhibition Immunologic Immunologic factors interleukin interleukin-6 mechanical ventilation Meta-analysis meta-regression Mild Mortality mortality risk outcome Patient patients with COVID-19 pharmacological intervention pharmacological interventions Placebo Primary outcome randomized-controlled RCT RCTs reduce reducing Regression reported required risk secondary secondary outcome Secondary outcomes sequential analysis severe COVID-19 severe disease standard care suggested systematic review therapeutic strategy Tocilizumab Treatment Trial trial sequential analysis TSA [DOI] 10.1007/s00134-021-06416-z PMC 바로가기 [Article Type] Meta-Analysis
Elevated serum SDMA and ADMA at hospital admission predict in-hospital mortality of COVID-19 patients입원 시 혈청 SDMA 및 ADMA 상승으로 COVID-19 환자의 병원 내 사망률 예측Article Published on 2021-05-102022-09-10 Journal: Scientific Reports [Category] SARS, 바이오마커, [키워드] Admission Algorithm analyzed association asymmetric AUC best Biomarker Biomarkers blood sample Blood samples calculated circulating Clinical course Concentration COVID-19 COVID-19 patient COVID-19 patients Critical Critical illness cut-off cut-offs death died disease hazard hazard ratio help high risk Hospital admission identify In-hospital death in-hospital mortality Mild symptom mild symptoms Mortality mortality risk Organ failure Patient patients hospitalized predict Predictive Prospective Risk factors ROC analyses ROC analysis sequential analysis serum severity significantly higher subgroups of patients Survivors viral infection [DOI] 10.1038/s41598-021-89180-w PMC 바로가기 [Article Type] Article
Interventions for treatment of COVID-19: Second edition of a living systematic review with meta-analyses and trial sequential analyses (The LIVING Project)COVID-19 치료를 위한 중재: 메타 분석 및 시험 순차 분석이 포함된 살아있는 체계적인 검토의 두 번째 판(The LIVING 프로젝트)Meta-Analysis Published on 2021-03-112022-08-13 Journal: PLoS ONE [Category] Biochemistry, SARS, 임상, 진단, 치료제, [키워드] 95% CI 95% confidence interval adjusted Admission aggregate data meta-analyses all age group all age groups all-cause mortality Analysis boundary bromhexine caused certainty certainty of evidence Clinical research Clinical significance Cochrane guidelines comparison Comparisons Corticosteroid Corticosteroids COVID-19 database Effect Effects eight events Evidence evidence of Families FIVE Fixed-effect meta-analysis futility GRADE high risk Hydroxychloroquine Immunoglobulin indicate indication indications individual patient data meta-analyses individuals information intensive care Intervention effects intravenous Intravenous immunoglobulin lack life Lopinavir Lopinavir-ritonavir mechanical ventilation meta-analyses Meta-analysis moderate Network meta-analysis no evidence of non-serious adverse non-serious adverse events on mechanical ventilation outcome outcomes participant Participants patient data performed Primary outcomes PRISMA Quality of life random error random errors random-effects meta-analyses randomized clinical trial randomized clinical trials rapidly spreading disease reached reduce reduced Remdesivir renal replacement therapy replacement therapy required Research risk risk of death risk ratio risks of bia Ritonavir searched second secondary Secondary outcomes sequential analysis Serious Adverse Event Serious Adverse Events single trial standard care statistically significant systematic review threshold Tocilizumab Treatment treatment for COVID-19 treatment intervention treatments of COVID-19 Trial Trial methodology trial sequential analyses trial sequential analysis website with COVID-19 [DOI] 10.1371/journal.pone.0248132 PMC 바로가기 [Article Type] Meta-Analysis
Efficacy and safety of systematic corticosteroids among severe COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials중증 코로나19 환자를 대상으로 한 전신 코르티코스테로이드의 효능 및 안전성: 무작위 대조 시험에 대한 체계적인 검토 및 메타 분석Meta-Analysis Published on 2021-02-212022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, MERS, 임상, [키워드] 95% confidence interval all-cause mortality Analysis applied approach assessment benefit calculate certainty CIs Controlled controlled trials coronavirus disease Coronavirus disease 2019 Corticosteroid Corticosteroids COVID-19 COVID-19 therapy death development Disease progression Enrollment evaluate evaluated Evidence excluded extracorporeal membrane oxygenation Follow-up ICU identify Immunotherapy incidence Infectious diseases intubation Meta-analysis not increased Occurrence outcome Patient Primary outcome progression random-effects model Randomized controlled trial Randomized controlled trials RCT RCTs recovery RECOVERY trial required Result risk risk ratio searched secondary Secondary outcomes sequential analysis Serious Adverse Event Serious Adverse Events severe coronavirus disease severe COVID-19 severe COVID-19 patients subjects suggested survival systematic corticosteroid systematic review transfer Trial trial sequential analysis Ventilated Ventilation [DOI] 10.1038/s41392-021-00521-7 PMC 바로가기 [Article Type] Meta-Analysis