From Detection to Protection: Antibodies and Their Crucial Role in Diagnosing and Combatting SARS-CoV-2Review Published on 2024-04-252024-09-05 Journal: Vaccines [Category] update2024, [키워드] Antibody-dependent enhancement convalescent plasma COVID-19 diagnostic Immunotherapy Long COVID neutralizing monoclonal antibodies Omicron subvariants original antigenic sin SARS-CoV-2 SARS-CoV-2-specific antibodies serological assays Vaccine variants of concern (VOC) [DOI] 10.3390/vaccines12050459 PMC 바로가기 [Article Type] Review
Dynamics of SARS-CoV-2 seroassay sensitivity: a systematic review and modelling studyarticle Published on 2023-05-252024-09-05 Journal: Eurosurveillance [Category] update2024, [키워드] antibody Meta-analysis SARS-CoV-2, COVID-19 serological assays serology Serosurveillance [DOI] 10.2807/1560-7917.ES.2023.28.21.2200809 PMC 바로가기 [Article Type] article
Evaluation and comparison of four quantitative SARS-CoV-2 serological assays in COVID-19 patients and immunized healthy individuals, cancer patients, and patients with immunosuppressive therapyArticle Published on 2023-02-262024-09-05 Journal: Clinical biochemistry [Category] update2024, [키워드] comparability SARS-CoV-2 vaccination serological assays Standardization [DOI] 10.1016/j.clinbiochem.2023.02.010 PMC 바로가기 [Article Type] Article
Validation of laboratory developed serology assays for detection of IgG antibody to severe acute respiratory syndrome coronavirus 2 in the South African population남아프리카 인구에서 중증 급성 호흡기 증후군 코로나바이러스 2에 대한 IgG 항체 검출을 위해 실험실에서 개발한 혈청학 분석의 검증Article Published on 2022-09-012022-09-11 Journal: Journal of virological methods [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 African antibody approved assays authority Beta characterization circulating collected commercial immunoassay Concordance confirmation continent Control coronavirus country Coverage cross-reactive antibodies cut-off value Delta demonstrated described determine diagnostic differentiation ELISA enzyme IFA IgA IgG IgG antibody IgM immunosorbent Infection infection rate investigated Laboratory Laboratory developed lateral flow limit Local mammalian molecular pandemic Patient persistence Population populations positive positive predictive values Predictive predictive values product Quality assurance resource respiratory RT-PCR RT-PCR positive patient SARS-CoV-2 SARS-CoV-2 spike protein sensitivity Serological assay serological assays serology assay serology assays Serology assays. serum sample serum samples severe acute respiratory syndrome Coronavirus shown small sample size South South Africa specificity Spike protein Surveillance tested Vaccine validation variant [DOI] 10.1016/j.jviromet.2022.114571 PMC 바로가기 [Article Type] Article
Production of novel SARS-CoV-2 Spike truncations in Chinese hamster ovary cells leads to high expression and binding to antibodiesArticle Published on 2022-09-012022-11-15 Journal: Biotechnology Journal [Category] COVID19(2023년), SARS, 진단, [키워드] antibody Antibody binding antibody binding. binding Cell cells Chinese hamster Chinese hamster ovary cells COVID-19 develop diagnostics domain eight elicit evaluated Express expressed expression full-length IMPROVE Infection Modification monoclonal antibody outperform platform polyclonal Production Protein purified pursuit raised RBD Research responses SARS-CoV-2 sensitivity serological assays significantly spike the Spike vaccination viral entry [DOI] 10.1002/biot.202100678 PMC 바로가기
Limited Correlation between SARS-CoV-2 Serologic Assays for Identification of High-Titer COVID-19 Convalescent Plasma Using FDA ThresholdsArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] antibody assay standardization assays authorization can be used CCP clinical trials Clinical use Cohort collected comparable Concordance consequence convalescent convalescent plasma COVID-19 COVID-19 convalescent plasma criteria Cutoff cutoff value Donor drug Emergency Emergency use authorization EUA Expanded Access Program FDA FDA EUA FIVE food high-titer CCP high-titer convalescent plasma highlight hospitalized patients identification identify immunosuppressed patients indicate Limited lowest monoclonal antibody multiple serological assay Pandemics Pathogens positive precluded provided ranged reduce released Roche SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant serologic serologic assay serological Serological assay serological assays serology serum sample significantly Standardization therapeutic therapeutic option therapy threshold Treatment [DOI] 10.1128/spectrum.01154-22 PMC 바로가기
Plasmonic Fluor-Enhanced Antigen Arrays for High-Throughput, Serological Studies of SARS-CoV-2SARS-CoV-2의 높은 처리량, 혈청학적 연구를 위한 플라즈몬 형광 강화 항원 어레이Article Published on 2022-08-122022-09-11 Journal: ACS Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] 96-well plate acute infection Antigen antigenic antigenic drift Bioscience Characteristics clinical sensitivity coordination COVID-19 pandemic Critical current diagnostics eight evaluate fluorescent highlight IgA IgG IgM Laboratory limitation limitations management microarray analysis microplate reader multiplex Outbreaks Patient Patient management plasmonics public health ranged reagents reminder response resulting Sample SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 detection SARS-CoV-2 positive patients Screening sensitivities sensitivity serological assays serological response serological studies SEROLOGICAL STUDY Serological testing serology several limitations specificity subset symptomatic used to evaluate Volume was performed were used [DOI] 10.1021/acsinfecdis.2c00086 PMC 바로가기 [Article Type] Article
High SARS-CoV-2 seroprevalence in Karaganda, Kazakhstan before the launch of COVID-19 vaccinationCOVID-19 예방 접종이 시작되기 전에 카자흐스탄 카라간다에서 높은 SARS-CoV-2 혈청 유병률Article Published on 2022-07-272022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] 95% CI Administered Antibody-mediated immunity appear Asia asymptomatic subjects capture Clinical characteristics Cohort collected Continuous correlated COVID-19 COVID-19 transmission COVID-19 vaccination death demographic and clinical characteristics detect detectable effort IgA IgG Immunity Infection Kazakhstan mitigate nasopharyngeal swabs National pandemic participant PCR-negative performed positive Prevalence provide public health Questionnaires recruited reported respiratory Respiratory illness RT-qPCR SARS-CoV-2 SARS-CoV-2 seroprevalence serological assays serological surveillance Serologically Seropositivity subject subset Swab tested the antibodies thresholds titre vaccination Virus neutralization were used [DOI] 10.1371/journal.pone.0272008 PMC 바로가기 [Article Type] Article
Template-Based Assembly of Proteomic Short Reads For De Novo Antibody Sequencing and Repertoire ProfilingDe Novo 항체 시퀀싱 및 레퍼토리 프로파일링을 위한 Proteomic Short Read의 템플릿 기반 어셈블리Review Published on 2022-07-262022-09-11 Journal: Analytical Chemistry [Category] MERS, 유전자 메커니즘, 진단, [키워드] Accuracy antibody antibody repertoire antibody sequence antibody sequences antigens assembly B-cells cDNA sequencing complementary dataset de novo disease Fab feature fluids foundation functional Health homologous homologous antibody hypermutation IgG information light chains Liquid chromatography mass mass spectrometry molecular monoclonal antibody offer Patient patients hospitalized polyclonal polyclonal antibodies polyclonal antibody Profiling proteomic provide Read Recombination repertoire secreted sequence Sequencing sera serological assays serum step Stitch Urine with COVID-19 [DOI] 10.1021/acs.analchem.2c01300 PMC 바로가기 [Article Type] Review
Overview of Neutralization Assays and International Standard for Detecting SARS-CoV-2 Neutralizing AntibodySARS-CoV-2 중화 항체 검출을 위한 중화 분석 및 국제 표준 개요Review Published on 2022-07-182022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antibody Response Antibody responses Antibody titer approach coronavirus coronavirus disease demonstrated detect determine disease disease outbreak Efficacy ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Health Organization International international standard international standard for SARS-CoV-2 International standards lateral flow microneutralization Microneutralization assay MONITOR Neutralization assay neutralization assays Neutralizing antibodies neutralizing antibody neutralizing antibody detection Neutralizing antibody titer outbreak outcome Patient respiratory SARS-CoV-2 SARS-CoV-2 pseudotype virus Serological assay serological assays severe acute respiratory syndrome Coronavirus Standard to define Vaccine vaccine efficacy World Health Organization [DOI] 10.3390/v14071560 PMC 바로가기 [Article Type] Review