SARS-CoV-2 non-structural protein 6 triggers NLRP3-dependent pyroptosis by targeting ATP6AP1
SARS-CoV-2 비구조 단백질 6은 ATP6AP1을 표적으로 하여 NLRP3 의존성 발열을 유발합니다
Article
[키워드] abrogated
activated
Activation
acute respiratory syndrome coronavirus
Analysis
Asymptomatic COVID-19
ATP6AP1
ATPase
autophagic flux
binding
caspase-1
coronavirus 2
coronavirus disease
Coronavirus disease 2019
COVID-19
demonstrated
epithelial cells
exhibited
impair
induce
Infection
Inflammasome
inflammasome activation
inflammasomes
inflammatory cell
Inflammatory cell death
inhibit
inhibited
interleukin
L37F
live SARS-CoV-2
lung epithelial cell
Lung epithelial cells
lung tissues
lysosome acidification
maturation
metformin
Mutation
NLRP3
non-structural protein
NSP6
overexpression
Patient
pharmacological
Polydatin
proton pump
pyroptosis
receptor signaling
reduced
respiratory
SARS-CoV-2
serological markers
severe acute respiratory syndrome Coronavirus
severe acute respiratory syndrome coronavirus 2
severe COVID-19
suggested
Support
Transcriptome
transcriptome analysis
Trigger
triggered
upstream
vacuolar
variant
viral pathogenicity
weakened
[DOI] 10.1038/s41418-021-00916-7 PMC 바로가기 [Article Type] Article
[DOI] 10.1038/s41418-021-00916-7 PMC 바로가기 [Article Type] Article