several variants – Communicable Diseases Research

An efficient approach for SARS-CoV-2 monoclonal antibody production via modified mRNA-LNP immunization

Article

Published on 2022-11-052022-11-15
Journal: International journal of pharmaceutics [Category] COVID19(2023년), SARS, 변종, 진단,

Molecular aspects of Omicron, vaccine development, and recombinant strain XE: A review

오미크론의 분자적 측면, 백신 개발 및 재조합 균주 XE: 검토

Review

Published on 2022-10-012022-09-11
Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제,

Effectiveness of Booster Doses of the SARS-CoV-2 Inactivated Vaccine KCONVAC against the Mutant Strains

Article

Published on 2022-09-122022-11-15
Journal: Viruses [Category] SARS, 변종, 진단, 치료기술,

Evolution of the SARS-CoV-2 omicron variants BA.1 to BA.5: Implications for immune escape and transmission

Article

Published on 2022-09-012022-11-15
Journal: Reviews in Medical Virology [Category] COVID19(2023년), SARS, 변종, 진단,

[키워드] administration antibody approved Booster vaccine Combination Community consequence current Delta delta variant diagnosed dominant dominant variant Efficacy Evolution FDA higher infectivity human lung tissue immune Immune escape immune evasion Immunity immunocompromised individual IMPROVE Infection less monoclonal monoclonal antibodies Mutation mutations neutralising omicron Omicron variant other variant Protein public health recombination event reduced reduction reported SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants several variants severity Sotrovimab spike Spread syncytia formation the SARS-CoV-2 therapeutic use Transmission Vaccine variant variants of SARS-CoV-2 Wuhan-Hu-1 zoonotic
[DOI] 10.1002/rmv.2381 PMC 바로가기

Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants

SARS-CoV-2 변종을 차단하는 범용 약제로서의 임상 등급 ACE2

Article

Published on 2022-08-082022-09-11
Journal: EMBO Molecular Medicine [Category] COVID19(2023년), SARS, 변종, 진단,

Structural basis of Omicron immune evasion: A comparative computational study

오미크론 면역 회피의 구조적 기반: 비교 전산 연구

Article

Published on 2022-08-012022-09-11
Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종,

[키워드] ACE2 Affect Analysis angiotensin antibody binding affinities binding affinity Compromised Compromised neutralisation Critical Delta develop effective Effectiveness Efficacy evaluated explain immune Immune escape immune evasion immunogenic interact Interaction interface mapped molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulations Mutation neutralisation Neutralising Antibodies neutralising antibody new strain omicron Omicron variant Protein RBD Receptor binding domain receptors reported robust S protein SARS-CoV-2 SARS-CoV-2 variants several variants Spike protein the antibody the binding affinity the spike protein Vaccine Vaccine design variant variants variants of concern virus
[DOI] 10.1016/j.compbiomed.2022.105758 PMC 바로가기 [Article Type] Article

Drug repurposing based on a quantum-inspired method versus classical fingerprinting uncovers potential antivirals against SARS-CoV-2

고전적 지문과 비교하여 양자에서 영감을 받은 방법을 기반으로 한 약물 용도 변경은 SARS-CoV-2에 대한 잠재적인 항바이러스제를 밝혀냅니다.

Article

Published on 2022-07-182022-09-11
Journal: PLoS Computational Biology [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제,

[키워드] accelerated Algorithm Alpha Antiviral antiviral therapeutics approach approved B.1.1.7 B.1.351 B.1.617.2 Beta binary BMS-986094 Cell culture classical cobalamin Combination comparison Comparisons complex complexity Compound compounds computational resource computational resources COVID-19 pandemic cytotoxicity Delta demonstrated Drug repurposing DrugBank database Efficacy England evaluate form GS-6620 IC50 identify in vitro inhibit inhibited inhibitors inhibitory concentration limit maximum optimization overlap pace parameter predicted problem RdRP Remdesivir replication of SARS-CoV-2 resolved RNA-dependent RNA polymerase SARS-CoV-2 SARS-COV-2 infection screening method several variant several variants strain these compound these compounds vitamin B12 while
[DOI] 10.1371/journal.pcbi.1010330 PMC 바로가기 [Article Type] Article

High-throughput drug screening allowed identification of entry inhibitors specifically targeting different routes of SARS-CoV-2 Delta and Omicron/BA.1

고용량 약물 스크리닝을 통해 SARS-CoV-2 Delta 및 Omicron/BA.1의 다양한 경로를 구체적으로 표적으로 하는 진입 억제제 식별 가능

Article

Published on 2022-07-012022-09-11
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘,

[키워드] acute respiratory syndrome coronavirus Alpha antagonist antagonists applied BA.1 Beta Caco2 cells Cathepsin-L cell entry cells cellular entry chlorpromazine Combination Compound D614G Delta drug Drug repurposing Drug screening Entry inhibitor FDA-approved drugs G protein G protein coupled receptor antagonist G-protein help highest identify Infection route inhibit inhibitors lentiviral Lentiviral vector lentiviral vectors mechanism membrane fusion omicron pathway phenothiazine preference pseudotyped pseudovirus pseudoviruses receptor receptor antagonist Receptor binding receptors respiratory responsible resulting SARS-CoV-2 several variant several variants Severe acute respiratory syndrome specific inhibitors spike variant synergistic targets TMPRSS2 variant variant of concern viral entry VoC VOCs
[DOI] 10.1016/j.biopha.2022.113104 PMC 바로가기 [Article Type] Article

Analysis of SARS-CoV-2 in Nasopharyngeal Samples from Patients with COVID-19 Illustrates Population Variation and Diverse Phenotypes, Placing the Growth Properties of Variants of Concern in Context with Other Lineages

COVID-19 환자의 비인두 샘플에서 SARS-CoV-2 분석은 다른 계통과 관련하여 우려되는 변이체의 성장 특성을 배치하여 인구 변이 및 다양한 표현형을 보여줍니다

Article

Published on 2022-06-292022-09-11
Journal: mSphere [Category] COVID19(2023년), SARS, 변종,

[키워드] A549 cells Alpha amplified Beta Beta variant Biology biology of SARS-CoV-2 causative agent Cell Cell culture cell line cells change characterized clinical isolates clinical samples concern Context coronavirus COVID-19 Delta disease effective Evolution genetic diversity genetics genome sequence genomic global pandemic growth growth kinetics hACE2 hospitalized patient hospitalized patients humans immune evasion increased risk indicated Infection isolate isolates less Lineage minor minor genomic variants morbidity Mortality Nasopharyngeal swab nasopharyngeal swabs New no difference not different omicron Other other coronaviruses other variant other variants pandemic patients pattern planet Population Population dynamics Population genetics Postinfection preserved property Research RNA RNA sequencing Sample SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes sequence several variants Spread suggested Transmission vaccination Vaccine Variability variant variants variants of concern variants of SARS-CoV-2 Variation Vero E6 Vero E6 cell VERO E6 cells virus Virus evolution VoC VOCs widespread with COVID-19
[DOI] 10.1128/msphere.00913-21 PMC 바로가기 [Article Type] Article

Effects of Spike Mutations in SARS-CoV-2 Variants of Concern on Human or Animal ACE2-Mediated Virus Entry and Neutralization

인간 또는 동물 ACE2 매개 바이러스 진입 및 중화에 대한 우려의 SARS-CoV-2 변이체에서 스파이크 돌연변이의 영향

Article

Published on 2022-06-292022-09-11
Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] ACE2 ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Affect angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal animals antibodies antibody Antibody neutralization antibody neutralization activity Beta caused cell entry cell line cell lines circulating common strain comparable concern coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic Delta determine Effect Effectiveness Efficiency Express expressing global health Health host range Human human ACE2 Impact infect infecting information mink MOST Mutation neutralization neutralizing antibody Neutralizing titer neutralizing titers nine omicron Omicron variant over pandemic parental Protein pseudovirus pseudoviruses public policy reduced respiratory reveal S protein S proteins SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 mutation SARS-CoV-2 S protein SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus sera several variant several variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown significantly socioeconomics spike spike mutations Spread Substitution substitutions Support susceptible tested the S protein the SARS-CoV-2 the SARS-CoV-2 virus therapeutic therapeutic antibodies Transmissibility Transmission Vaccine variant variants variants of concern variety Viral viral cell viral entry viral neutralization virulence virus virus entry virus replication VoC VOCs zoonotic
[DOI] 10.1128/spectrum.01789-21 PMC 바로가기 [Article Type] Article