Phase II/III trial of hyperimmune anti-COVID-19 intravenous immunoglobulin (C-IVIG) therapy in severe COVID-19 patients: study protocol for a randomized controlled trialArticle Published on 2022-11-082022-11-16 Journal: Trials [Category] SARS, 변종, [키워드] adaptive anti-COVID-19 IVIG antivirals clinical evidence clinical trial collected convalescent convalescent plasma COVID-19 cumulative death Efficacy eligibility criteria evaluate Health hyperimmune immunization immunomodulators intravenous Intravenous immunoglobulin low dose monoclonal antibodies Neutralizing non-specific novel Novel coronavirus outcome Passive passive immunization Patient phase Pneumonia polyclonal polyclonal antibodies Pooled convalescent plasma Potential treatment Randomized Randomized controlled trial receive Recovered COVID-19 patients reported SARS CoV-2 SARS CoV-2. SARS-CoV-2 sealed Secondary outcomes severe COVID-19 severe COVID-19 patient severe COVID-19 patients Standard of care Steroids Study protocol therapeutic option therapy treat Treatment Trial variant variants of concern virus virus particles World Health Organization [DOI] 10.1186/s13063-022-06860-2 PMC 바로가기
Vitamin D enhances type I IFN signaling in COVID-19 patientsArticle Published on 2022-10-222022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료제, [키워드] 95% confidence interval adjusted hazard ratio Admission all-cause mortality antimicrobial peptide Antiviral Antiviral effect antiviral response collected COVID-19 infection COVID-19 patient ENhance Host host response IFN in vitro intensive care interferon investigated ISGs JAK-STAT signaling pathway lower risk modulate on type outcome patient survival patients PBMC protein level Regulatory saliva specimen SARS-CoV-2 SARS-COV-2 infection severe COVID-19 patient Signaling significantly higher treated treated patient treated patients Treatment Type I IFN untreated patient Vitamin D Whole blood [DOI] 10.1038/s41598-022-22307-9 PMC 바로가기
TIMELESS is a key gene mediating thrombogenesis in COVID-19 and antiphospholipid syndromeArticle Published on 2022-10-142022-11-15 Journal: Scientific Reports [Category] 유전자 메커니즘, 진단, [키워드] Analysis analysis antibody autoantibody autophagy gene Bioinformatics analysis Cell circadian clock Coagulation contribute COVID-19 COVID-19 patient COVID-19 patients Critically ill cytoHubba Cytoscape software dataset Differentially expressed genes evaluated expression Genes Genetic GSK3B identify Immune-mediated Immunotherapy increased risk Interference investigated Kyoto mechanism Mild Modification mononuclear cell ontology term pathway Patient patients protein-protein interaction Proteins regulate severe COVID-19 severe COVID-19 patient severe COVID-19 patients severity suggested Symptom syndrome therapeutic potential thrombosis Transcriptome were used with COVID-19 [DOI] 10.1038/s41598-022-21694-3 PMC 바로가기
Neuropathological findings in fatal COVID-19 and their associated neurological clinical manifestationsArticle Published on 2022-10-012022-11-16 Journal: Pathology [Category] COVID19(2023년), SARS, 치료기술, [키워드] Autopsy Brain calculated case sery CD8 Cell Central nervous system clinical clinical manifestation clinical manifestations correlated correlation COVID-19 described Encephalopathy fatal COVID-19 FIVE highest hospitalisation hypoxic IL-6 illness duration intensive care lesion lesions macrophage activation syndrome microglial microthrombi Neuroinflammation neurological Neurological symptoms neuropathology. no correlation one patient onset of symptoms parameter pathology Patient patients performed Pituitary proportion qRT-PCR quantification retrospective SARS-CoV-2 RNA severe COVID-19 patient systemic inflammation T-cell activation Two patient Vascular [DOI] 10.1016/j.pathol.2022.03.006 PMC 바로가기
Classification of lungs infected COVID-19 images based on inception-ResNetResearch article Published on 2022-10-012022-10-05 Journal: Computer methods and programs in biomedicine [Category] 진단, 치료기술, [키워드] 3D convolution Accuracy applied auxiliary backbone carried Chest classification Classifier Clinical diagnosis collected data COVID-19 COVID-19 diagnosis COVID-19 patient CT imaging CT scan dataset diagnose diagnostic disease effective Efficiency effort ENhance expected experiment greater hospital identify image classification IMPROVE Inception-ResNet lung mechanism medical diagnosis Numerous objective Patient performed Perspective Prevent processed Result Severe case severe COVID-19 patient Spread survival the disease TPR Treatment [DOI] 10.1016/j.cmpb.2022.107053 [Article Type] Research article
Comparative Upper Respiratory Tract Transcriptomic Profiling Reveals a Potential Role of Early Activation of Interferon Pathway in Severe COVID-19Article Published on 2022-10-012022-11-15 Journal: Viruses [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] Acute respiratory infection Comparative Coronavirus disease 2019 COVID-19 COVID-19 negative COVID-19 patient COVID-19 patients death driving evaluated Genes Host transcriptional response host-pathogen interactions IFN-I IFN-I response Inflammation initial symptom interferon involved ISG ISGs lung mechanism Mild OAS Potential Profiling progression respiratory Respiratory failure RNA-Seq RNA-sequencing role SARS-CoV-2 severe COVID-19 patient severe COVID-19 patients severe symptom stimulated symptomatic patient the disease tract type I interferon upper upper respiratory tract upregulated viral infection Viral infection. Viral load [DOI] 10.3390/v14102182 PMC 바로가기
Presepsin Predicts Severity and Secondary Bacterial Infection in COVID-19 by Bioinformatics AnalysisArticle Published on 2022-09-062022-11-15 Journal: Computational and Mathematical Methods in Medicine [Category] SARS, 바이오마커, [키워드] acute respiratory disease Analysis AUC biological processes caused CD14 cellular components Coronavirus pneumonia COVID-19 COVID-19 patient Critical datasets deaths DEGs Diagnosis diagnostic value differentially expressed gene downregulated enrichment analysis expression function Gene ontology KEGG Kyoto limit majority moderate molecular function nonsurvivor novel novel coronavirus SARS-CoV-2 Pathway enrichment analysis PPI predict Prognosis protein-protein interaction screened secondary secondary bacterial infection selected severe COVID-19 severe COVID-19 patient severity significantly significantly higher significantly increased survivor Treatment upregulated utility was performed [DOI] 10.1155/2022/9914927 PMC 바로가기
Highlights of clinical and laboratory parameters among severe COVID-19 patients treated with tocilizumab: a retrospective observational studyArticle Published on 2022-09-012022-11-15 Journal: São Paulo medical journal = Revista paulista de medicina [Category] 진단, 치료기술, [키워드] Admission age analysis analyzed C-reactive protein (CRP Chest Clinical characteristics Comparative conducted Coronavirus disease 2019 COVID-19 COVID-19 patient CRP CRP level CRS Cytokine release syndrome database died disease evaluate ferritin high mortality hospital Hospitalized IL-6 independent risk factor information interleukin-6 laboratory parameter Logistic regression analysis lymphocyte Mortality neutrophil no difference oxygen saturation Patient performed receiving Research retrospective severe COVID-19 patient Signal transduction significantly lower suppresse survival group survived the patient Tocilizumab tocilizumab administration treated Treatment Turkey WBC White blood cell [DOI] 10.1590/1516-3180.2021.0604.R1.23112021 PMC 바로가기
Incidence of thromboembolic complications in hospitalized COVID-19 patients in a medical ward in Japan: A single-center retrospective and prospective observational studyObservational Study Published on 2022-08-192022-10-05 Journal: Medicine [Category] 임상, [키워드] 95% CI addition Admission age Asian Asymptomatic body mass index complications of COVID-19 conducted COVID-19 COVID-19 patient Critical determine died events hallmark higher risk hospital hospitalized COVID-19 patient identify incidence intensive care IQR Ischemia Japan Japanese limb median Mild moderate Myocardial infarction occurred Patient Prevalence Primary outcome prospective cohort study prospective observational study Prospective Study retrospective Severe case severe COVID-19 severe COVID-19 patient severity of COVID-19 single-center stroke symptomatic the median thromboembolic complication thromboembolic complications transferred Venous Thromboembolism women [DOI] 10.1097/MD.0000000000029933 PMC 바로가기 [Article Type] Observational Study
Evaluating the effect of Edaravone on clinical outcome of patients with severe COVID-19 admitted to ICU: a randomized clinical trialRandomized Controlled Trial Published on 2022-08-012022-10-04 Journal: Inflammopharmacology [Category] COVID19(2023년), SARS, 임상, [키워드] accompanied addition administration admitted to ICU anti-inflammatory properties antioxidant Characteristics clinical complications Clinical improvement Clinical outcome control group coronavirus disease COVID-19 decrease Edaravone Endotracheal intubation Endpoint evaluate the effect Evaluating groups hallmark hospital ICUs immune response induce Injury intensive care unit intervention arms intervention group intravenous intubation Laboratory test mechanical ventilation Mechanical ventilation. Medical Science Mortality mortality rate National outcome overactive Patient Pneumonia Primary outcome Randomized randomized clinical trial receiving reduce secondary secondary endpoint severe COVID-19 severe COVID-19 patient single-center stimulate Tabriz therapy university viral infection [DOI] 10.1007/s10787-022-01001-2 PMC 바로가기 [Article Type] Randomized Controlled Trial