severe acute respiratory syndrome Coronavirus – Communicable Diseases Research

SARS-CoV-2 shedding dynamics and transmission in immunosuppressed patients

면역 억제 환자의 SARS-CoV-2 발산 역학 및 전파

Article

Published on 2022-12-012022-09-11
Journal: Virulence
[Category] COVID19(2023년), SARS, 변종, 치료기술,

An engineered 5-helix bundle derived from SARS-CoV-2 S2 pre-binds sarbecoviral spike at both serological- and endosomal-pH to inhibit virus entry

SARS-CoV-2 S2에서 파생된 조작된 5나선 번들은 바이러스 진입을 억제하기 위해 혈청학적 pH와 엔도솜 pH 모두에서 사베코바이러스 스파이크를 사전 결합합니다.

Article

Published on 2022-12-012022-09-11
Journal: Emerging Microbes & Infections
[Category] COVID19(2023년), SARS, 변종,

[키워드] 5-helix bundle (5HB) acute respiratory syndrome acute respiratory syndrome coronavirus bind binding Broad-spectrum inhibition can not cell membrane construction coronavirus Evidence feature fusion heptad repeat highlighting host cell host cells IC50 infections inhibit neutralize peptide peptides pre-fusion predominant Protein sarbecovirus sarbecovirus Sarbecoviruses SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 S2 SARS-CoV-2 variant SARS-CoV-2 variants serological severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 structural basis These data Treatment viral entry viral entry. viral spike virus entry virus infection
[DOI] 10.1080/22221751.2022.2095308 PMC 바로가기 [Article Type] Article

Severity of SARS-CoV-2 Omicron BA.2 infection in unvaccinated hospitalized children: comparison to influenza and parainfluenza infections

예방접종을 받지 않은 입원 소아에서 SARS-CoV-2 Omicron BA.2 감염의 심각도: 인플루엔자 및 파라인플루엔자 감염과의 비교

Article

Published on 2022-12-012022-09-11
Journal: Emerging Microbes & Infections
[Category] COVID19(2023년), SARS, 변종,

[키워드] 95%CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjusted Admission children Clinical outcome coronavirus COVID-19 COVID-19 infection Croup database death had no hospitalisation hospitalisations Hospitalization Hospitalized Infection Influenza Influenza virus initial investigated Mild neurological Neurological complication Neurological complications occurred omicron outcome parainfluenza parainfluenza virus proportion Public Hospital Relative risk required respiratory. retrieved risk SARS-CoV-2 severe acute respiratory syndrome Coronavirus severity uninfected upper airway upper airways vaccination variant viral infections virus viruses were recorded
[DOI] 10.1080/22221751.2022.2093135 PMC 바로가기 [Article Type] Article

SARS-CoV-2 pseudovirus enters the host cells through spike protein-CD147 in an Arf6-dependent manner

SARS-CoV-2 슈도바이러스는 Arf6 의존적 방식으로 스파이크 단백질-CD147을 통해 숙주 세포에 들어갑니다.

Article

Published on 2022-12-012022-09-11
Journal: Emerging Microbes & Infections
[Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach Arf6 blockade CD147 cells clathrin Clathrin-mediated endocytosis clinically coronavirus endocytic endocytic mechanism endocytosis evaluate feasible function host cell host cells Huh-7 cell Huh-7 cells independent independent of indicated infected Vero E6 cells Infection inhibited inhibitor knockdown Localization macropinocytosis pathway Prevent pseudovirus pseudovirus infection public health RAB5A SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 pseudovirus infection severe acute respiratory syndrome Coronavirus Spike protein spike protein. Spread the SARS-CoV-2 variant Vero E6 VERO E6 cells viral infection weakened
[DOI] 10.1080/22221751.2022.2059403 PMC 바로가기 [Article Type] Article

Research progress on vaccine efficacy against SARS-CoV-2 variants of concern

우려되는 SARS-CoV-2 변이체에 대한 백신 효능 연구 진행

Review

Published on 2022-11-302022-09-11
Journal: Human vaccines & immunotherapeutics
[Category] COVID19(2023년), SARS, 변종,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition caused contributed coronavirus COVID-19 COVID-19 vaccine declined Delta Efficacy Epidemic epidemic wave Epidemics Health Organization Immune escape Measures Neutralizing Neutralizing antibodies omicron Omicron variants pathogenicity Prevention and control Protective Research research and development SARS-CoV-2 SARS-CoV-2 variant severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 triggered vaccination Vaccine vaccine efficacy variant Variant of concern. variants variety VoC VOCs WHO World Health Organization
[DOI] 10.1080/21645515.2022.2057161 PMC 바로가기 [Article Type] Review

Binding and neutralizing abilities of antibodies towards SARS-CoV-2 S2 domain

SARS-CoV-2 S2 도메인에 대한 항체의 결합 및 중화 능력

Article

Published on 2022-11-302022-09-11
Journal: Human vaccines & immunotherapeutics
[Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibodies antibody B.1.1.7 B.1.351 B.1.617.2 B.1.621 binding binding activity carried conserved convalescent patient coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 determined by domain ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluated Evidence Immune escape immune protection mAb mAbs MERS MERS-CoV Middle East Middle East respiratory syndrome Middle East respiratory syndrome Coronavirus molecular monoclonal antibodies monoclonal antibody N Terminal N terminal domain NAbs Neutralization assay neutralization assay. Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody NTD P.1 Protein pseudo-virus RBD Receptor binding domain reported Research respiratory Result S protein S proteins S2 protein S2 subunit SARS-CoV SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 S SARS-CoV-2 S2 SARS-CoV-2 WT Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus significantly specific antibodies subunit target targets terminal Vaccine design variant variants wild-type
[DOI] 10.1080/21645515.2022.2055373 PMC 바로가기 [Article Type] Article

Analysis of the mutation dynamics of SARS-CoV-2 genome in the samples from Georgia State of the United States

미국 조지아주 샘플에서 SARS-CoV-2 게놈의 돌연변이 역학 분석

Article

Published on 2022-10-202022-09-11
Journal: Gene
[Category] COVID19(2023년), SARS, 변종, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Algorithm Amino acid analysis Analysis caused China clade clades Complete coronavirus disease Coronavirus disease 2019 Coronavirus-2 country Course COVID-19 D614G determine disease England Europe Filter Genome genome sequence Genome sequences Host indicate limit majority Multiple Multiple studies mutated Mutation N501Y NCBI database Novel coronavirus novel coronavirus SARS-CoV-2 nucleotide nucleotides online tool over P681H pandemic Phylogenetic Quality control reference genome SARS-CoV-2 SARS-CoV-2 genome SARS-CoV2 sequence Sequence alignment sequenced genomes sequences severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe acute respiratory syndrome coronavirus-2. Spread state survival the United State the WHO translation Transmission variant variants virus was used Wuhan
[DOI] 10.1016/j.gene.2022.146774 PMC 바로가기 [Article Type] Article

Theoretical investigation on the interactions of microplastics with a SARS-CoV-2 RNA fragment and their potential impacts on viral transport and exposure

SARS-CoV-2 RNA 단편과 미세 플라스틱의 상호 작용 및 바이러스 수송 및 노출에 대한 잠재적 영향에 대한 이론적 조사

Article

Published on 2022-10-102022-09-11
Journal: The Science of the total environment
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect affinity Behavior Behavior and fate cause condition coronavirus coronavirus disease Coronavirus disease-19 COVID-19 determine electrostatic environmental conditions Environmental pollution Evidence exposure to facilitate FIVE greater HBV hepatitis B Hepatitis B virus Human hydrophobic Impact independent independent of inherent Interaction involved Lungs mechanism media Microplastic pollution microplastics molecular molecular dynamic simulations molecular interaction molecular volume Nucleic acid material pandemic pandemic spread parameter polar risk RNA RNA fragment SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 transmission SARS-CoV-2. severe acute respiratory syndrome Coronavirus Spread strong interaction surface area temperature the SARS-CoV-2 Transport vacuum virus water
[DOI] 10.1016/j.scitotenv.2022.156812 PMC 바로가기 [Article Type] Article

Clinical efficacy and in vitro neutralization capacity of monoclonal antibodies for severe acute respiratory syndrome coronavirus 2 delta and omicron variants

중증급성호흡기증후군 코로나바이러스 2 델타 및 오미크론 변이체에 대한 단일클론항체의 임상적 효능 및 시험관내 중화능

Article

Published on 2022-10-012022-09-11
Journal: Journal of medical virology
[Category] COVID19(2023년), SARS, 변종, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Casirivimab casirivimab/imdevimab clinical Concentration coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient decrease delta variant dosage Efficacy except for exhibit Hospital stay Imdevimab in vitro in vitro data in vivo Infection mAb mAbs monoclonal monoclonal antibodies monoclonal antibody neutralization Neutralization assay neutralization capacity neutralizing capacity neutralizing effect Omicron variant Patient patients treated performed provided receiving respiratory respiratory tract respiratory viral RNA SARS-CoV-2 SARS-CoV-2 delta SARS-CoV-2 RNA severe acute respiratory syndrome Coronavirus sotromivab Sotrovimab the SARS-CoV-2 therapeutic therapy treated variant Viral Virus neutralization virus neutralization assay. virus neutralization assays
[DOI] 10.1002/jmv.27916 PMC 바로가기 [Article Type] Article

Antiviral efficacy of selective estrogen receptor modulators against SARS-CoV-2 infection in vitro and in vivo reveals bazedoxifene acetate as an entry inhibitor

시험관 내 및 생체 내에서 SARS-CoV-2 감염에 대한 선택적 에스트로겐 수용체 조절제의 항바이러스 효능은 진입 억제제로서 바제독시펜 아세테이트를 나타냅니다

Article

Published on 2022-10-012022-09-11
Journal: Journal of medical virology
[Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제,

[키워드] Acetate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-SARS-CoV-2 antiviral efficacy Bazedoxifene bazedoxifene acetate candidate cholesterol cholesterol distribution citrate clinical Clomifene Clomifene citrate contagious coronavirus Coronaviruses Critical delta variant distribution drugs Effect Efficacy endosome acidification Estrogen estrogen receptor evaluated exhibited expression hamster hamsters human cell lines humans identify in vitro in vivo infect Infection information inhibited inhibitor interleukin-6 offer omicron Omicron variant pathogenic variant penetration Postinfection pseudovirus pseudoviruses pulmonary viral reduced reveal SARS-CoV SARS-CoV-2 SARS-COV-2 infection selective selective estrogen receptor modulator severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Severe acute respiratory syndrome coronavirus 2. Tamoxifen toremifene toremifene citrate variant Vero E6 Vero E6 cell VERO E6 cells weight loss
[DOI] 10.1002/jmv.27951 PMC 바로가기 [Article Type] Article